Protein-free natural rubber latex, process for producing the same and use thereof

A technology of natural rubber latex, manufacturing method, applied in applications, male contraceptives, catheters, etc., can solve problems such as incomplete protein removal

Inactive Publication Date: 2007-04-11
SUMITOMO RUBBER IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the rubber gloves made of low-protein natural rubber latex produced by this deproteinization method have been clinically tested through a more rigorous test method, namely the scratch method, to confirm that about 8% of patients still have Type I allergic reactions. Positive, in this sense the removal of protein is not complete (refer to R.Hayakawa et al., Environ.Dermatol., 6, 10 (1999))

Method used

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  • Protein-free natural rubber latex, process for producing the same and use thereof
  • Protein-free natural rubber latex, process for producing the same and use thereof
  • Protein-free natural rubber latex, process for producing the same and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] In 1.9L of fresh latex (abbreviated as FL latex) adjusted to 30% DRC (dry rubber content), add 100 mL aqueous solution containing 30 g of sodium hydroxide and Emulgen-70 (polyoxyethylene nonyl) as a nonionic surfactant Phenyl ether) 4g, carry out saponification reaction at 70 ℃ for 3 hours. The latex solution was centrifuged at 13000 rpm for 8 minutes to separate the cream phase, and water was added to the cream phase to adjust to 60% DRC. Then 0.5 g of ammonium laurate was added.

[0055] Proteins present in the cream phase and the serum phase of the saponified natural rubber latex thus obtained were determined by the SDS-PAGE method.

[0056] The protein contained in the cream phase was determined as follows.

[0057] 17 g of the cream phase was extracted with 17 mL of 2% SDS at room temperature for 24 hours. Using a dialysis membrane with a molecular weight cut-off of 3.5 kDa, the extract was dialyzed at room temperature for 24 hours while stirring in cold water. ...

Embodiment 2～4

[0061] Example showing changes in saponification conditions of natural rubber latex

[0062] Saponification conditions are shown in Table 1. The experiment was carried out under the same conditions as in Example 1 except for the saponification conditions. In the cream phase of these saponified natural rubber latexes, no bands of 14, 31 and 45 kDa appeared in the results of SDS-PAGE measurement.

[0063] saponification condition

Example 2

NaOH 1%-70℃-1 hour

Example 3

NaOH 2% - room temperature - 5 hours

Example 4

NaOH 3% - room temperature - 2.5 hours

[0064] In the table, saponification conditions represent the concentration (w / v%) of NaOH, reaction temperature, and reaction time.

[0065] The results of SDS-PAGE measurement of the cream phase of the obtained latex under the same conditions as in Example 1 are shown in FIG. 4 . Under the conditions of Examples 2-4, no bands of 14, 31, and 45 kDa appeared at all. It was fo...

Embodiment 5～6

[0068] It carried out similarly to Example 1. However, the compounds of Table 2 were used instead of Emulgen-70 as the surfactant. As a result, it can be seen that none of the latexes of the examples contained the proteins of the bands of 14, 31 and 45 kDa as measured by SDS-PAGE.

[0069] Example

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PUM

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Abstract

A natural rubber latex which is substantially free from proteins specified respectively by bands at 14, 31 and 45 kDa in the SDS-PAGE method; and a process for producing the natural rubber latex as described above which comprises saponifying a natural rubber latex with an alkali hydroxide in the presence of a surfactant. Because of substantially being free from the above proteins causative of the expression of type I allergy, the above-described natural rubber latex is appropriately usable in producing various products such as catheters, rubber gloves, condoms and foamed articles.

Description

technical field [0001] The present invention relates to natural rubber latex from which protein has been removed, its production method and use. More specifically, it relates to a natural rubber latex substantially free of a protein of a specific molecular weight peculiar to natural rubber latex, a method for producing the same, and a use thereof. Background technique [0002] So far, natural rubber has been widely used in industrial products such as automobile tires, aircraft tires, and belts. The natural rubber can be collected as a latex containing water, protein, inorganic salts, etc. in addition to rubber components, and the latex can be coagulated to produce raw rubber (crepe rubber or smoked rubber). This kind of raw rubber can be made into required rubber products through mastication, compounding, molding and vulcanization. In addition, many industrial products are manufactured from natural rubber latex itself. For example, it is used in the manufacture of balloon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08C1/04A41D19/00A61F6/04A61L29/00C08J9/30C08L7/00A61L29/04A61L31/04
CPCC08C1/04A61L29/042A61F6/04A61L31/049
Inventor 田中康之塞达皮帕尼池·吉拉达
Owner SUMITOMO RUBBER IND LTD
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