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Composition for type i allergy

A kind of composition, type I technology, applied in the composition of especially allergic reaction, preventing or improving the field of type I allergy, can solve the problems such as inability to guarantee safety, side effects, etc., achieve high usefulness and practicability, high safety Effect

Inactive Publication Date: 2020-08-21
ASAHIKOHSAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are opinions that these drugs cause various side effects, and their safety cannot be guaranteed

Method used

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  • Composition for type i allergy
  • Composition for type i allergy
  • Composition for type i allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Isolation and identification of lactic acid bacteria

[0061] 1. Isolation of Lactic Acid Bacteria Samples

[0062] Select the leaves, stems and fruits of figs (variety "とよみつ姫"), use sterilized forceps and scissors to cut them into small pieces of 2-3 mm, and then add them to a sterilized medium containing MRS liquid medium. 5 to 6 fragments were placed in each test tube, and statically cultured at 28° C. and 37° C. until the MRS medium, which is a standard medium for lactic acid bacteria, became cloudy (proliferated). In addition, it took 2 to 4 days until the growth of the candidate lactic acid bacteria strain could be visually observed.

[0063] A part of each culture solution of the above-mentioned lactic acid bacteria candidate strain was streak-inoculated on the MRS agar medium with a disposable inoculating loop, and then cultured statically. Among the colonies formed on the agar medium, select all "colony colonies with different colors, luster, and shapes", and...

Embodiment 2

[0084] 1. Isolation and purification of polysaccharides produced by IJH-SONE68 strain

[0085] The polysaccharides produced by the IJH-SONE68 strain were isolated and purified by the following method.

[0086] The IJH-SONE68 strain was cultured statically in MRS liquid medium until the stationary phase of proliferation. 5 mL of this culture solution was inoculated into 5 L of a semi-synthetic medium for polysaccharide production (the composition will be described later) as a bacterial stock solution, and cultured at 37° C. for 120 hours. After cooling the culture solution to 4° C., 202.5 mL of 100% trichloroacetic acid aqueous solution was added to denature the protein contained in the culture supernatant and removed as a precipitate in a subsequent step, mixed and left to stand for 30 minutes. The precipitate was removed by centrifugation, an equal amount of acetone was added to the recovered supernatant, mixed, and allowed to stand overnight at 4° C., thereby precipitating ...

Embodiment 3

[0146] Inhibitory effect of IJH-SONE68 strain on active skin allergic reaction in mice

[0147] The inhibitory effect of the lactic acid bacteria of the IJH-SONE68 strain obtained in Example 1 on the active skin allergic reaction in mice was investigated according to the method described below.

[0148] 1. Test method

[0149] (1) Preparation of samples for mouse test

[0150] The Lactobacillus paracasei IJH-SONE68 strain was cultured for 48 hours in fruit juice medium (final concentration of pineapple juice: 50%, final concentration of Japanese sake extract: 10%), and the fermentation broth was concentrated 2-fold, and used as a sample for the mouse test. It is estimated that this sample contains polysaccharides including a neutral polysaccharide component and an acidic polysaccharide component at a concentration of about 40 mg / L, wherein the above-mentioned polysaccharides are polysaccharides produced by the IJH-SONE68 strain obtained in Example 2 .

[0151] (2) Reagents ...

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Abstract

This composition, which contains, as active ingredients, microbial cells of a lactobacilli belonging to Lactobacillus paracasei, a cultured product or fermented product thereof, or a polysaccharide produced by the same, is effective for preventing or alleviating type I allergy. In particular, this composition can be used as food, medication, animal food, and cosmetics for preventing or alleviatinganaphylaxis.

Description

technical field [0001] The present invention relates to compositions for type I allergy. In more detail, the present invention relates to a composition for preventing or improving type I allergy, especially anaphylaxis, wherein the above-mentioned composition is formulated with the thallus of lactic acid bacteria belonging to Lactobacillus paracasei (Lactobacillus paracasei), its culture or fermented product, Or the polysaccharide produced by it is used as an active ingredient. Background technique [0002] In recent years, it has been pointed out that allergies such as hay fever, atopic dermatitis, and contact dermatitis have increased significantly due to various reasons such as changes in eating habits, worsening air pollution, allergen substances, and exposure to metallic decorations. . Allergy is based on an immune response and is a systemic or localized disorder to a living organism. Also, allergies are roughly classified into type I, II, and III allergies based on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23K10/10A23K20/163A23L2/38A23L2/52A23L33/125A61K8/73A61K8/99A61K31/715A61K35/747A61P37/08A61Q1/00
CPCA23L2/52A61K35/747A61K31/715A23K20/163A61P37/08A23L33/125A23L33/135A23K10/12A23K10/16A23K10/18A23V2002/00A61K36/60A23V2400/165A23V2200/304A23V2200/3204A23V2250/51A61K2300/00A61K8/99A61K8/73A61K8/9789A61Q19/00A23L33/40A61K2035/115A61K2800/10A61K2800/72
Inventor 杉山政则
Owner ASAHIKOHSAN
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