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Application of clarithromycin in preparation of type I allergy resisting drugs

A kind of technology of clarithromycin and allergic reaction, applied in the application field of clarithromycin in the preparation of anti-type 1 allergy medicine, can solve problems such as the increase of bioavailability, achieve less side effects, better absorption, and inhibit mast cell degranulation reaction Effect

Inactive Publication Date: 2018-09-18
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Food intake is generally considered to have no significant effect on the bioavailability of clarithromycin, although increased bioavailability in the presence of food in the stomach has been reported

Method used

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  • Application of clarithromycin in preparation of type I allergy resisting drugs
  • Application of clarithromycin in preparation of type I allergy resisting drugs
  • Application of clarithromycin in preparation of type I allergy resisting drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Antagonizing IgE-mediated release of β-hexosaminidase from human mast cells

[0026] 1) Reagents

[0027] 0.1% Triton X-100 Lysis Solution: Dissolve 10 μL Triton X-100 in 10 mL PBS to obtain 0.1% Triton X-100 Lysis Solution.

[0028] 0.1mol / L citric acid / sodium citrate buffer solution (pH4.5): Weigh 2.101g citric acid monohydrate, dissolve in 100mL tri-distilled water to obtain 0.1mol / L citric acid solution, protect from light at 4°C save. Weigh 2.941 g of sodium citrate and dissolve it in 100 mL of three-distilled water to obtain a 0.1 mol / L sodium citrate solution, which is stored at 4°C in the dark. Before use, mix in the ratio of 0.1 mol / L citric acid: 0.1 mol / L sodium citrate=10.4:9.6 (v / v) to obtain 0.1 mol / L citric acid / sodium citrate buffer solution.

[0029] 1 mmol / L β-hexamine solution: Weigh 0.034 g of β-hexamine and dissolve it in 100 mL of 0.1 mol / L citric acid / sodium citrate buffer solution to obtain 1 mmol / L β-hexamine solution.

[0030] 0.1mol / L ...

Embodiment 2

[0047] 1) Reagents

[0048] For the preparation of 0.5% CMC-Na solution, 0.5 g of CMC-Na was added to 100 mL of physiological saline, and dissolved by ultrasonic to obtain 0.5% CMC-Na solution. The preparation of 1 μg / mL DNP-IgE solution is obtained by diluting 1 mg / mL finished DNP-IgE solution one thousand times with normal saline. For the preparation of 1 μg / mL DNP-HSA solution, 100 mg of DNP-HSA powder was weighed, 0.1 mL of normal saline was added, and after ultrasonically dissolved, it was diluted 100 times to obtain 1 μg / mL DNP-HSA solution.

[0049] 2) Experimental steps

[0050] Fifty C57BL / 6 mice at 7-8 weeks were randomly divided into 5 groups, 3 different concentration administration groups, negative control group and blank control group, with 10 mice in each group. Three different concentration administration groups, negative control group and blank control group were injected with 0.2 mL of 1 μg / mL DNP-IgE solution through tail vein. In the blank control group,...

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PUM

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Abstract

The invention relates to application of clarithromycin in preparation of type I allergy resisting drugs. The clarithromycin has new use of pharmaceutical compounds for antagonizing and treating allergic reactions; the drugs are tablets, controlled release formulations, injections or spray dosage forms; the clarithromycin plays a role in lowering the rise of IgE mediated mouse serum histamine; in addition, the clarithromycin plays a role in antagonizing IgE mediated human mastocytes to release beta-hexosaminidase. The clarithromycin has potential exploitability in treatment of immunologic diseases.

Description

technical field [0001] The invention belongs to the field of antibiotic medicines, and in particular relates to the application of clarithromycin in the preparation of anti-type I allergy medicines. Background technique [0002] Clarithromycin is one of the most popular and promising second-generation macrolide antibiotics. Its chemical name is 6-O-methylerythromycin A, which was developed by Japan's Taisho Company. The developed 14-membered ring erythromycin derivatives have the following structures. The structure of clarithromycin is similar to that of erythromycin, but the rearrangement of 6-9 and 9-12 of the lactone ring is blocked because its 6-hydroxyl group is substituted by methyl, so that clarithromycin can overcome the acidity of erythromycin. The macrocyclic molecule has the disadvantage of losing the antibacterial activity due to the change of the spiroketal in the environment, and reducing the adverse reactions of the gastrointestinal tract. Clarithromycin als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P37/08
CPCA61K31/7048A61P37/08
Inventor 张涛贺怀贞车德路贺浪冲
Owner XI AN JIAOTONG UNIV
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