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Activatable particles, preparations and uses.

A particle and nanoparticle technology, used in biochemical equipment and methods, radiation sensitizing materials, preparation of X-ray contrast agents, etc., can solve the problems of patients with photosensitivity and limited frequency

Inactive Publication Date: 2007-04-18
NANOBIOTIX SA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, photodynamic therapy has some limitations
For example, patients may develop photosensitivity that limits the number of times the therapy is administered in a given individual
In addition, the low-wavelength radiation used to excite the photosensitive molecules prevents them from passing through larger thicknesses of tissue, which has the advantage of low toxicity to other tissues, but limits its indication to superficial cancers (skin and subcutaneous)

Method used

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  • Activatable particles, preparations and uses.
  • Activatable particles, preparations and uses.
  • Activatable particles, preparations and uses.

Examples

Experimental program
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Effect test

Embodiment Construction

[0114]1. Y doped with Erbium or Gadolinium 2 o 3 Preparation of nanoparticles

[0115] Y doped with erbium or gadolinium 2 o 3 Nanoparticles are synthesized from functionalized surfactants (Y-AOT 3 , Eu-AOT 3 , and Gd-AOT 3 ). Mix the appropriate surfactant mixture (based on the desired final concentration [Eu-AOT 3 ] / [Y-AOT 3 ]=0.01; 0.05; 0.1; 0.15) dispersed in isooctane or cyclohexane. Water was added to promote micelle formation. The size of the micelles, which affects the size of the material obtained, is controlled by the amount of water added to the mixture. Hydroxide is formed by adding base. The particles were then rinsed with a water / ethanol mixture, dried and heated at 800°C in order to form crystalline nanoparticles.

[0116] 10 mg of nanoparticles were dispersed in 50 ml of water at pH 7.5. A drop of this dispersion was deposited onto a copper / carbon grid and observed under a transmission electron microscope. Micrographs are shown in FIG. 3 .

[01...

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Abstract

The invention relates to activatable novel particles which can be used in the health sector. The invention more particularly relates to composite particles which can generate free radicals or heat when excited by X-rays. The invention also relates to the uses thereof in human health. The inventive particles comprise an inorganic-based, and optionally organic-based, nucleus and can be activated in vivo in order to mark or affect cells, tissue or organs. The invention further relates to methods for the production of said particles, and pharmaceutical or diagnostic compositions containing them.

Description

technical field [0001] The present application relates to novel activatable particles that can be used in the health field. In particular it relates to composite particles which can generate free radicals or heat when excited by X-rays, and to their use especially in human health. The particles of the invention comprise an inorganic-based, and optionally organic-based, inner core and can be activated in vivo by controllable external stimulation in order to mark or alter cells, tissues or organs. The invention also relates to methods for producing said particles, and to pharmaceutical or diagnostic compositions comprising said particles. Background technique [0002] Photodynamic therapy (PDT) has been described and is currently used to treat superficial cancers such as skin cancer or esophageal cancer (see, e.g., McCaughan, J.S.Jr., Drugs and Aging. 15:49-68 (1999) "Photodynamic Therapy: A Review "). The treatment is based on free radicals generated by photosensitive mole...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K9/14A61P35/04A61K41/00A61K49/04
CPCA61K41/0038B82Y5/00A61K49/0423A61N5/062A61N5/10A61N2005/0661A61N2005/1098A61P35/00A61P35/04A61P43/00A61K47/50A61K9/14A61K9/16A61K51/12A61K41/0052C12N13/00
Inventor 洛朗·莱维让-弗朗索瓦·奥舍皮耶杰里米·巴朗西帕拉斯·纳特·普拉萨德厄尔·吉姆·伯吉爱德华·安德烈·保纳克阿卜杜勒·卡德·布萨
Owner NANOBIOTIX SA
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