The invention discloses a synthesis method of
epinastine. The synthesis method is implemented by taking 2-aminobenzophenone as a
raw material and comprises the following steps of: reacting the 2-aminobenzophenone with a
silane agent to obtain 2-benzylaniline; then, carrying out
acylation reaction on the 2-benzylaniline and 2-
chloroacetyl chloride to obtain N-(2-benzyl phenyl)-2-
chloroacetamide; carrying out acidamide
dehydration and cyclization on the N-(2-benzyl phenyl)-2-
chloroacetamide under the action of a dehydrating agent to obtain 6-(chloromethyl)-11H-dibenzo[b,e]
azepine; carrying out azidation reaction on the 6-(chloromethyl)-11H-dibenzo[b,e]
azepine to obtain 6-(azido-methytbiphenyl)-11H-dibenzo[b,e]
azepine; carrying out reduction on the 6-(azido-methytbiphenyl)-11H-dibenzo[b,e] azepine to obtain 6-(aminomethyl)-6,11-dihydro-1H-dibenzo[b,e] azepine; and finally, carrying out cyclization on the 6-(aminomethyl)-6,11-dihydro-1H-dibenzo[b,e] azepine and
cyanogen bromide to obtain the
epinastine. The synthesis method disclosed by the invention avoids the application of expensive and flammable
lithium aluminium hydride and
aluminium hydride as well as hypertoxic
sodium cyanide, so that the operation is
safer in industrial production, and the cost is reduced. The method is simple in process and high in yield, requires mild conditions, and is suitable for industrialized production.