Endotoxin adsorptive material, preparing and use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 浙江科锐生物科技有限公司
- Publication Date
- 2005-02-23
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Technical field:
[0001] The invention relates to the field of biomedical materials, in particular to an affinity adsorption material capable of adsorbing and removing endotoxin molecules in a liquid mobile phase and a preparation and use method thereof. Background technique:
[0002] Endotoxin is a lipopolysaccharide molecule from the cell wall of Gram-negative bacteria. Endotoxin enters the blood of mammals and can cause fever. When the amount of endotoxin in the blood reaches a certain limit, it can directly cause death. Escherichia coli (a typical Gram-negative bacterium) often appears in the intestinal tract of these animals, but the general toxicity will disappear after being absorbed by the liver, and Escherichia coli and endotoxin will not be found in normal human blood. However, when the patient's liver function declines, he receives anticancer drug treatment, or suffers from severe trauma (burn or surgery), he is prone to severe bacterial infectious diseases, follow...