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Method for preparing compound in category of cyanopyridine

A technology for cyanopyridine and compounds, which is applied in the field of preparation of 2-cyanopyridine compounds, can solve the problems of long process route, difficult industrial implementation, and low reaction yield, and achieve the effect of short process route and convenient industrial implementation

Inactive Publication Date: 2007-05-09
上海安基生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned method not only needs expensive raw materials, but also has a low reaction yield. Due to the use of heavy metals, toxic waste liquid will be produced, the process route is long, and it is difficult to implement industrially.

Method used

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  • Method for preparing compound in category of cyanopyridine
  • Method for preparing compound in category of cyanopyridine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Catalyst preparation:

[0037] (1) Put 50 grams of V 2 o 5 with 80 g Zr 2 o 2 Dissolve in 300ml of sulfuric acid aqueous solution with a weight concentration of 70%, add 20 grams of carrier inert alumina balls, soak for 2 hours, filter, collect the filter cake, and dry at 120°C for 3 hours;

[0038] (2) immerse the product of step (1) in 100 ml of Cr-containing sulfuric acid aqueous solution with a weight concentration of 25% for 3 hours, filter, collect the filter cake, and dry at 120° C. for 3 hours;

[0039] (3) The product of step (2) is immersed in 85ml containing Al 2 o 3 The weight concentration is 10% sulfuric acid aqueous solution for 5 hours, filter, collect filter cake, 120 ℃ dry 24 hours, obtain catalyst 1;

[0040] The general formula of the catalyst obtained is as follows:

[0041] (V a Zr b x c Y d o e ) f (Z) g

[0042] Wherein: a=11; b=15; c=5; d=3; e=7; f=95% by weight; g=5% by weight.

Embodiment 2

[0044] The preparation of catalyst is identical with embodiment 1, wherein:

[0045] X is Fe;, Y is Si;

[0046] The general formula of the catalyst obtained is as follows:

[0047] (V a Zr b x c Y d o e ) f (Z) g

[0048] Wherein: a=10; b=13; c=5; d=3; e=6; f=97% by weight; g=3% by weight.

[0049] Catalyst 2 is obtained.

Embodiment 3

[0051] The preparation of the catalyst was the same as in Example 1.

[0052] Carrier is desulfurization active carbon, in step (1), 110 dry 24 hours, wherein:

[0053] a=13; b=15; c=0; d=0; e=2; f=100% by weight; g=0% by weight to obtain catalyst 3.

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PUM

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Abstract

This invention discloses a method for preparing 2-cyanopyridine compounds. The method comprises: reacting 2-methylpyridine with a mixture of NH3 and O2 in the presence of (VaZrbXcYdOe) f (Z) g catalyst, and collecting 2-cyanopyridine compounds from the products. The method does not need expensive raw materials, and does not generate toxic wastewater. Besides, the process is simple, and 2-cyanopyridine can be obtained simply by distillation of the products.

Description

technical field [0001] The invention relates to a preparation method of 2-cyanopyridine compounds. Background technique [0002] 2-cyanopyridine compounds are important pharmaceutical intermediates, which can be used in the preparation of pesticides and animal feed additives. [0003] At present, many patents have reported the preparation method of 2-cyanopyridine compounds, generally introducing a cyano group at the 2-position of pyridine, which is usually included in polar solvents such as dimethylsulfoxide or dimethylformamide Substitution of halogen, especially bromine or fluorine, as in EP0034917, preparation of 2-cyano-3-chloro-5-trifluoromethane from 2-bromopyridine in dimethylformamide at 120°C with cuprous cyanide Base pyridine, again as the technology of CN0372550A report, with 2,3-dichloro-5-trifluoromethyl pyridine, cyanide, activator 4-dimethylaminopyridine and solvent reaction generate 3-chloro-2-cyano group -5-Trifluoromethylpyridine. [0004] The above-men...

Claims

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Application Information

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IPC IPC(8): C07D213/84B01J8/06
Inventor 郑戈邓志华
Owner 上海安基生物科技股份有限公司
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