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Glycyrrhizin-containing suppository compositions for rectal infusion

A glycyrrhizic, rectal technique

Inactive Publication Date: 2007-06-13
MINOPHAGEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, these oral preparations must add medium-chain fatty acids such as capric acid, which is highly irritating to the mucous membranes, as an absorption enhancer, and there are safety problems as mentioned above.
Also, as mentioned above, almost all of GL is decomposed into GA in the digestive tract, so its effect is not sufficient

Method used

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  • Glycyrrhizin-containing suppository compositions for rectal infusion
  • Glycyrrhizin-containing suppository compositions for rectal infusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6 and comparative example 1

[0137] Mix monoammonium glycyrrhizinate and oily base agent according to the mixing amount (mass %) shown in Table 1, further add nonionic surfactant, stir evenly in a mortar, add water, carry out thorough mixing, and obtain the rectal injection containing GL Suppository compositions.

[0138] In addition, the abbreviations in Table 1 have the following meanings.

[0139] GL-NH 4 : Monoammonium glycyrrhizinate

[0140] J-1811: Sucrose fatty acid ester with HLB of 11 (manufactured by Mitsubishi Chemical Fu-zu Co., Ltd.)

[0141] S-24D: Polyglycerol fatty acid ester with HLB of 10 (manufactured by Mitsubishi Chemical Fu-zu Co., Ltd.)

[0142] L-7D: Polyglycerol fatty acid ester with HLB of 17 (manufactured by Mitsubishi Chemical Fu-zu Co., Ltd.)

[0143] PGMSV: Polyglycerol fatty acid ester with HLB of 14 (manufactured by Nisshin Oirio Co., Ltd.)

[0144] ミブリオ-ル: ミブリオ-ル812 (medium-chain fatty acid triglycerides with a fatty acid composition of 50-65% caprylic acid and 30-45...

Embodiment 14～27

[0228] According to the composition and mixing amount (mass %) shown in Table 9~11, utilize homogenizer, evenly suspend monoammonium glycyrrhizinate (GL-NH 4 ), an oily base, a nonionic surfactant, purified water or an aqueous alkali solution, and fully stirred to prepare a rectal injection suppository composition containing GL. In addition, in Example 25, gerline (Benzalkonium salt) was further added to prepare a composition.

[0229] In Examples 19 to 27 using the above-mentioned aqueous alkali solution, the ratio (mass %) of the water component and the alkali component in the composition is shown in parentheses.

[0230] In addition, the abbreviations in Tables 9 to 11 have the following meanings.

[0231] SS: Sucrose fatty acid ester with HLB of 19 (manufactured by Daiichi Kogyo Pharmaceutical Co., Ltd.)

[0232] F-160: Sucrose fatty acid ester with HLB of 15 (manufactured by Daiichi Kogyo Pharmaceutical Co., Ltd.)

[0233] J-1811: HLB is 11 sucrose fatty acid ester (ma...

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Abstract

A glycyrrhizin-containing suppository composition for rectal infusion which comprises at least one member selected from among glycyrrhizin and pharmaceutically acceptable salts thereof, a nonionic surfactant, an oily base, and water and which exhibits a solid-liquid phase transition point of 10 to 4500Pa at 37 DEG C; and a glycyrrhizin-containing suppository composition for rectal infusion which comprises at least one member selected from among glycyrrhizin and pharmaceutically acceptable salts thereof, an oily base, water, and an alkali.

Description

technical field [0001] The present invention relates to rectal injection suppository composition containing glycyrrhizic acid and its preparation method, medicine for liver disease, medicine for skin disease, medicine for antiallergic reaction, medicine for treating SARS and medicine for treating AIDS containing the composition for rectal injection suppository containing glycyrrhizic acid . [0002] This application claims priority based on Japanese application No. 2004-191275 filed on June 29, 2004 and Japanese application No. 2004-371222 filed on December 22, 2004, and the contents of the earlier applications are cited in this application. Background technique [0003] Glycyrrhizic acid (hereinafter referred to as GL) and its salts have been known to have a wide range of physiological activities such as anti-allergic effects, anti-inflammatory effects, immune regulation, liver cell damage inhibition, liver cell proliferation promotion, and virus reproduction inhibition. h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/02A61K47/02A61K47/14A61K47/18A61K47/26A61K47/34A61K47/44A61P1/06A61P17/00A61P37/08
Inventor 花田卓石黑晓子浜田雄二井上秀雄佐藤俊次
Owner MINOPHAGEN PHARMA
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