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Chinese-medicinal preparation for treating AIDS and its production

A technology for AIDS and drugs, which is applied in the field of drug preparation, can solve problems such as lack of quality control indicators, difficulties in clinical use, and large dosages, and achieve easy portability and long-term uninterrupted medication, easy to carry and take, take The effect of small doses

Active Publication Date: 2010-05-05
HAINAN ASIA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there have been many reports and patent applications for traditional Chinese medicine preparations for the treatment of AIDS, but most of them have no strict pharmacodynamic experiment results, no long-term investigations on their safety and stability, and lack of quality control indicators. And some The preparation is too rough, the dosage is too large, and it is difficult to use in clinical practice. For example, application number 95115948.8 discloses a Chinese patent medicine "AIDS Kangning" and its preparation technology. They belong to traditional Chinese medicine poisons, but the inventors did not conduct any investigation on their toxicity, nor did they have stability investigations and quality control standards. At the same time, the medicines used have many flavors, high costs, and excessive dosages. And in the description of their efficacy There are exaggerations divorced from objective facts and lack credibility.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Weigh raw materials according to the following ratio (kg)

[0110] Epimedium 4.0

[0111] Astragalus 3.5

[0112] Red hair five plus skin 5.0

[0113] Scutellaria baicalensis 2.5

[0114] Licorice 0.7

[0115] The production method is as follows:

[0116] Take Epimedium and cut into 3-15mm herbal silk; cut Acanthopanax bark into 3-15mm medicine segments; grind astragalus, scutellaria baicalensis, and licorice, and take the coarse powder filtered through a 10-mesh sieve; mix the crushed medicinal materials, add Water with 3 times the weight of the medicinal material is used as a solvent, and the mixture of the medicinal material and the solvent is sent to the mass transfer device of the differential pressure displacement extraction equipment, and an instantaneous alternating pressure of 2.5MPa is applied. After about 20 minutes, a negative pressure of -0.05MPa is quickly applied. For about 35 minutes, the positive and negative pressures were alternately carried out ...

Embodiment 2

[0120] Weigh raw materials according to the following ratio (kg)

[0121] Epimedium 4.7

[0122] Astragalus 2.0

[0123] Anticanthus bark 4.0

[0124] Scutellaria baicalensis 2.0

[0125] Licorice 1.2

[0126] The production method is as follows:

[0127] Take epimedium and cut into 3-15mm herb silk; cut Acanthopanax bark into 3-15mm medicine segments; grind astragalus, scutellaria baicalensis, and licorice, and take the coarse powder filtered through a 30-mesh sieve; place the crushed medicine in countercurrent extraction In the conveyor of the equipment, add water 5 times the weight of the medicinal material as a solvent, collect the extract that is 4 times the weight of the medicinal material, concentrate the extract at -0.1MPa to a relative density of 1.05, add ethanol to make the alcohol concentration reach 65% volume Percent concentration, stand still, precipitate out, separate the alcohol precipitate, wash with 75% volume percent ethanol, suck dry, and vacuum dry a...

Embodiment 3

[0131] Weigh raw materials according to the following ratio (kg)

[0132] Epimedium 5.0

[0133] Astragalus 3.0

[0134] Acanthopanax bark 5.5

[0135] Scutellaria baicalensis 1.0

[0136] Licorice 0.8

[0137] The production method is as follows:

[0138] Take Epimedium and cut into 3-15mm herb silk; cut Acanthopanax bark into 3-15mm medicine segments; grind astragalus, scutellaria baicalensis, and licorice, and take the coarse powder filtered through a 20-mesh sieve; mix the pulverized medicinal materials evenly, and Use water as a solvent, add solvent to wet the medicinal material for 4 hours, put it into a percolator, add solvent until the medicinal material is submerged, soak for 2 hours, start percolation, percolate at a flow rate of 7ml / min / kg, and collect 6 times the weight of the medicinal material The percolation solution, the percolation solution is concentrated under reduced pressure at -0.1MPa to a relative density of 1.05, and ethanol is added to make the al...

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PUM

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Abstract

A Chinese medicine in the form of capsule, tablet, or particle for treating AIDS is prepared from 5 Chinese-medicinal materials including epimedium, astragalus root, scutellaria root, liquorice root,etc through breaking, mixing, wetting with solvent, countercurrent extracting, or pressure-difference extracting, or percolation extracting, concentrating, adding ethanol or methanol, depositing, separating deposit, drying, pulverizing, sieving, and shaping.

Description

technical field [0001] The invention relates to a medicine for treating AIDS, specifically a Chinese patent medicine prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. It belongs to the field of traditional Chinese medicine. Background technique [0002] AIDS is a foreign infectious disease, that is, acquired immunodeficiency syndrome. The disease is an infectious disease transmitted through blood, sexual contact and vertical transmission. Since the first case was reported in the United States in 1981, more than 60 million people have been infected with HIV in various countries around the world, of which more than 20 million people have died of AIDS, and the spread speed and scope of the disease have not been effectively controlled . At present, the epidemiological situation of AIDS in my country is also very severe, and it is one of the countries with rapid growth in the world. The 2004 China AIDS Prevention and Control Join...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61K9/16A61K9/20A61K9/48A61P31/18
Inventor 黄尧洲张莅峡张龙清张兴权
Owner HAINAN ASIA PHARM CO LTD