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Compound recipe pharmaceutical composition of traditional Chinese medicine and Western medicine for treating liver diseases

A composition and drug technology, applied in the field of medicine, to achieve the effects of promoting liver fat decomposition, uniform and stable drug quality, and inhibiting liver fibrosis

Inactive Publication Date: 2007-07-04
JIANGSU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, utilizing the interaction of Gynostemma pentaphyllum and diisopropylamine dichloroacetate or diisopropylamine ascorbate (vitamin), compatible prescriptions, for the preparation of medicines for the treatment of liver diseases such as acute and chronic hepatitis, fatty liver have not yet been reported

Method used

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  • Compound recipe pharmaceutical composition of traditional Chinese medicine and Western medicine for treating liver diseases
  • Compound recipe pharmaceutical composition of traditional Chinese medicine and Western medicine for treating liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 Preparation of Gypenosides

[0098] Take Gynostemma pentaphylla, add 75% ethanol to reflux and extract twice, each time for 2 hours, filter, recover ethanol from the liquid until it has no alcohol smell, add water to make a solution equivalent to 2g of crude drug per 1ml, stir well, let cool, and let it stand Place overnight, filter, and the filtrate passes through the treated macroporous resin column, first flush the column with 2 times the column volume of water, discard the water, and then elute with 3 times the column volume of 60% ethanol, collect the eluted liquid, recovering ethanol, concentrating to a concentrated solution with a relative density of 1.08 to 1.10, and spray drying to obtain.

[0099] Three batches of Gynostemma pentaphyllum extracts were prepared respectively, and the yield and content of the extracts are shown in Table 7.

[0100] identify

[0101] Take 0.5g of Gypenosides, add methanol to dissolve, and make a solution containing 10m...

Embodiment 2

[0108] Embodiment 2 Preparation of JE composition aqueous injection

[0109] prescription:

[0110] Gypenosides 60g

[0111] Diisopropylamine dichloroacetate 20g

[0112] Sodium Gluconate 19g

[0113] Polysorbate 80 50g

[0114] Add water for injection to 5000ml

[0115] A total of 1000 sticks were prepared

[0116] Preparation Process:

[0117]1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0118] 2) Add gypenosides into water for injection with a dosing volume of 30%, heat and stir to dissolve completely. Add diisopropylamine dichloroacetate and sodium gluconate into a small amount of water for injection, add the prescribed amount of polysorbate 80, heat and stir to dissolve.

[0119] 3) Combine the above solutions and add water for injection to the full amount.

[0120] 4) Add activated carbon for needles with a do...

Embodiment 3

[0128] The preparation of embodiment 3 JE composition powder injection

[0129] prescription:

[0130] Gypenosides 60g

[0131] Diisopropylamine dichloroacetate 20g

[0132] Sodium Gluconate 19g

[0133] Polysorbate 80 20g

[0134] Mannitol 400g

[0135] Add sterile water for injection to 3000ml

[0136] A total of 1000 sticks were prepared

[0137] Preparation Process:

[0138] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0139] 2) Weigh the raw and auxiliary materials according to the prescription quantity.

[0140] 3) Add gypenosides into water for injection with a dosing volume of 30%, heat and stir to dissolve completely. Add diisopropylamine dichloroacetate and sodium gluconate into a small amount of water for injection, add the prescribed amount of polysorbate 80, heat and stir to dissolve. Combine the above solutions and ...

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Abstract

The invention belongs to the field of medical technology, discloses a novel drug combinations and its preparation methods, the drug combinations mainly made by gynostemma pentaphylla and pantanevril or its acceptable pharmaceutical salt, and its weight ratio is: gynostemma pentaphylla 400 ~ 10000, pantanevril or its acceptable pharmaceutical salt 4 ~ 100. Or by gypenosides and pantanevril or its acceptable pharmaceutical salt, and its weight ratio is: gypenosides 12 ~ 300, pantanevril or its acceptablepharmaceutical salt 4 ~ 100. Among them, the pantanevril or its acceptable pharmaceutical salt optimizes dichloroacetic acid salt and ascorbic acid salt. The drug combination can be made to any clinical or pharmaceutical acceptable formulations and the injection and oral formulations is prepared. The drug combinations mainly apply to liver disease.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly made of gynostemma or its extract and diisopropylamine or a pharmaceutically acceptable salt thereof, a preparation method and application thereof. 2. Background technology [0002] Liver disease is a common and frequently-occurring disease, especially the acute and chronic liver disease caused by viral hepatitis dominates in my country, with a high incidence rate and a large coverage. There are 120 million people infected with hepatitis B virus in my country alone, about 300,000 per year People die from liver disease, half of which are primary cancers, which shows that liver disease is extremely harmful to people's health. [0003] According to relevant statistics, at present, the incidence of fatty liver in adults in my country is about 10%, and fatty liver has become a common and frequently-occurring disease in clinical practice. Fatty liv...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61P1/16A61K31/19A61K31/375
Inventor 黄振华
Owner JIANGSU UNIV OF TECH
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