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Novel metabolic targets and markers

a metabolic target and marker technology, applied in the field of metabolic targets and markers, to achieve the effect of increasing pemt activity and preventing a subject's birth d

Inactive Publication Date: 2006-06-29
TETHYS BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007] In yet another embodiment, the present invention provides a method for increasing the PEMT activity in a subject. The method includes administering to the subject an effective amount of an agent selected from the group consisting of folic acid, vitamin B6, growth hormone, sex hormone, β-3 adrenergic receptor agonist, niacin, and S-adenosylmethionine.
[0032] In yet another embodiment, the present invention provides a method of increasing milk production in a subject. The method comprises administering to a subject in need of such treatment an agent, wherein the agent increases PEMT activity and whereby increases milk production of the subject.
[0033] In another embodiment, the present invention provides a method of increasing the lipid content of milk in a subject. The method comprises administering to a subject in need of such treatment an agent, wherein the agent increases PEMT activity and whereby increases the lipid content of milk, wherein the lipid is 22:6n3 or 20:4n6.
[0034] In another embodiment, the present invention provides a method of increasing the phospholipid content of milk in a subject. The method comprises administering to a subject in need of such treatment an agent, wherein the agent increases PEMT activity and whereby increases the phospholipid content of milk.
[0037] In another embodiment, the present invention provides a method of preventing a birth defect of a subject. The method comprises administering to the maternal host of the subject an agent, wherein the agent increases PEMT activity, 22:6n3, or 20:4n6 in the maternal host of the subject.

Problems solved by technology

In addition, certain metabolites are believed to be the cause of various abnormal conditions.

Method used

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Examples

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examples

[0098] The following examples are intended to illustrate but not to limit the invention in any manner, shape, or form, either explicitly or implicitly. While they are typical of those that might be used, other procedures, methodologies, or techniques known to those skilled in the art may alternatively be used.

example i

Lipid Activity and Cardiovascular Diseases

[0099] Factors that influence both production of lipoproteins and the size and density distribution of lipoproteins play a major role in the pathogenesis of cardiovascular disease.

[0100] Very-low density lipoproteins (VLDL) are triacylglycerol-rich particles that are assembled from lipids in the liver. The major factor regulating hepatic very low-density lipoprotein (VLDL) assembly and secretion is the availability of lipids, such as PC, the major phosphospholipid component of VLDL. The active synthesis of PC is required for VLDL secretion from rat hepatocytes (Yao Z M, Vance D E 1988. J Biol Chem 263: 2998-3004.). Their studies with rat hepatocytes suggested that hepatic secretion of VLDL, but not high-density lipoprotein (HD), required active PC biosynthesis. Their study showed that the inhibitory effect of choline deficiency on VLDL secretion can be compensated for by the methylation of PE (the PEMT pathway).

[0101] Yao and Vance (1990....

example ii

Lipid Activity and Neurological Conditions

[0115] There is a strong correlation between liver PEMT activity and plasma phosphatidylcholine 20:4n6 and 22:6n3 concentrations (FIG. 2). These fatty acids are essential for neurodevelopment and other neurological processes. Thus, agents that affect PEMT activity stand to affect neurodevelopment, etc. This is interesting in light of the fact that folate, known to decrease the rate of birth defects, up-regulates PEMT activity and alcohol, known to increase birth defects, down-regulates PEMT activity.

Alcohol

[0116] The web site for the Center for Disease Control states that “Children exposed to alcohol during fetal development can suffer a wide array of disorders, from subtle changes in I.Q. to profound mental retardation. They can also suffer growth retardation in varying degrees and be born with birth defects of major organ systems.” (http: / / www.cdc.gov / ncbddd / fas / default.htm).

[0117] The metabolic basis for the influence of alcohol on n...

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Abstract

The present invention provides metabolic markers and targets, especially PEMT activity and metabolic markers and components associated therewith useful for diagnosing and treating various disease conditions.

Description

RELATED APPLICATIONS [0001] The present application claims priority under 35 U.S.C. § 19(e) from provisional application Nos. 60 / 363,587, filed Mar. 11, 2002; 60 / 373,912, filed Apr. 19, 2002; 60 / 401,684, filed Aug. 6, 2002; 60 / 424,949, filed Nov. 8, 2002 and 60 / 436,192 filed Dec. 24, 2002.FIELD OF THE INVENTION [0002] This invention relates generally to the field of metabolic targets and markers, especially their therapeutic and diagnostic applications. BACKGROUND OF THE INVENTION [0003] Metabolites and metabolic pathways are closely associated with biological conditions and functions in a system, e.g., human. Several disease conditions or conditions susceptible to certain diseases can be linked with the levels of certain metabolites or metabolic profiles. In addition, certain metabolites are believed to be the cause of various abnormal conditions. Therefore, there is a need in the field to identify metabolic markers and targets for therapeutic or diagnostic applications. SUMMARY OF...

Claims

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Application Information

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IPC IPC(8): C12Q1/48A61K38/45A61K31/00A61K31/51A61K31/519A61K38/00A61K38/22A61K38/27C12N9/10G01N33/574G01N33/92
CPCA61K31/00A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/7076A61K38/27C12N9/1003C12Y201/01017G01N33/57484G01N33/92G01N2800/52A61P25/00A61P9/00
Inventor WATKINS, STEVEN M.BAILLIE, REBECCA A.
Owner TETHYS BIOSCI
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