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Aromatase activating agent

a technology of activating agent and aromatase, which is applied in the direction of algae medical ingredients, drug compositions, metabolic disorders, etc., can solve the problems that direct administration is not appropriate for prevention or amelioration, and achieve the effect of prevention, amelioration or treatmen

Inactive Publication Date: 2007-02-22
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a drug or cosmetic composition that can prevent or improve various lesions caused by estrogen deficiency by stimulating the production of estrogen. This is achieved by using natural substances found in plants and algae that can activate the enzyme aromatase, which is responsible for converting androgen to estrogen. The invention includes the use of specific plants such as mulberry bark, ginseng, cucumber, and phellodendron bark, or chlorella, or their extracts. The invention also provides a method for preventing, improving, or treating lesions caused by estrogen deficiency by administering these plants or their extracts.

Problems solved by technology

Meanwhile, estrogen or estrogen-like substances are endocrine disruptors, and therefore, their direct administration is not appropriate for the prevention or amelioration of the above-mentioned symptoms or lesions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

production example 1

Production of Mulberry Bark Extract

[0030] Mulberry bark (10 g) was subjected to extraction with an aqueous ethanol solution (50 v / v %, 25 mL) for about seven days at room temperature, followed by filtration, to thereby yield a mulberry bark extract (yield: 11 mL, evaporation residue: 11.6 w / v %).

production example 2

[0031] Extracts of the plants and chlorella listed in Table 1 below were prepared in accordance with the process of Production Example 1.

TABLE 1Portion subjectedSolvent employedPlantto extractionfor extractionGinsengRoot90% EthanolCucumberImmature fruit40% 1,3-ButanediolPhellodendron barkBark50% EthanolChlorellaWhole algaeWater

referential example 1

Construction of Reporter Gene Assay System

[0032] Genomic DNA was extracted from a human normal keratinocyte sample. A DNA fragment in the genomic DNA, the fragment containing a transcriptional control region of human aromatase gene exon 1c and a portion of the exon 1c, was amplified through PCR by use of the following primers.

upper primer5′-GACTAGTAAACAACCACAAAACTGCTC-3′(SEQ ID NO: 1)lower primer5′-AACTGCAGACAAGTCAAAACAAGGAAGC-3′(SEQ ID NO: 2)

[0033] The PCR product was treated with restriction enzymes SpeI and PstI, and the product was transferred into a SeaPansy null control vector (TOYO INK MFG. CO., LTD.) at SpeI and PstI sites thereof. The product was used as an Ex1c-luc plasmid in the luciferase assay described below.

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PUM

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Abstract

The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, and phellodendron bark; or chlorella; or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.

Description

BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] The present invention relates to an aromatase activating agent which augments activity of aromatase, an enzyme which biosynthesizes estrogen from androgen. [0003] 2. Background Art [0004] Estrogen represents a class of female hormones which, in humans, are produced primarily in the ovaries. Some known members falling under estrogen are 17β-estradiol, estrone, and estriol. [0005] Estrogen participates in a variety of physiological functions, such as proliferation of the endometrium, and regulation of sexual functions, bone metabolism, and lipid metabolism. Therefore, when the level of estrogen in the body drops with ageing and ovarian functions deteriorate, a variety of pathological conditions are induced, such as menopause symptoms, hypogonadism, autonomic imbalance, lipid metabolism abnormality, vasomotor instability, and osteoporosis. [0006] Meanwhile, estrogen or estrogen-like substances are endocrine disruptors,...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/254A61K36/42A61K36/02A61K8/96A61K8/97A61K8/99A61K36/00A61K36/05A61K36/23A61K36/258A61K36/28A61K36/60A61K36/75A61K36/756A61P3/06A61P9/00A61P15/00A61P19/00A61P19/10A61P25/00A61P43/00
CPCA61K8/97A61K36/05A61K36/258A61K36/28A61K36/42A61K36/756A61Q19/00A61K8/9722A61K8/9789A61P3/06A61P9/00A61P15/00A61P19/00A61P19/10A61P25/00A61P43/00
Inventor KAKUO, SHINGOMORIWAKI, SHIGERUOHUCHI, ATSUSHIKUSUOKU, HIROSHI
Owner KAO CORP
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