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Use of fragrance compositions for the prevention of the development of indole base malodours from fecal and urine based soils

Inactive Publication Date: 2008-02-07
TAKASAGO INTERNATIONAL CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0024]A further preferred form of the invention relates to the use of fragrance compounds selected among: aldehydes, α,β-unsaturated aldehydes and allylic alcohols which satisfy the

Problems solved by technology

Consequently preventing, countering, reducing or destroying malodour is not straightforward.
Activated carbon and zeolites have been used as absorbents for malodours but these are not suited for incorporation into many products.
Antimicrobial agents such as zinc compounds and Triclosan (2′,4′,4′-trichloro-2-hydroxy-diphenyl ether) are used to kill microorganisms involved in producing malodours, but many are non-specific and can lead to imbalances in the natural microflora.
Herein lies a major disadvantage of using perfumes to mask malodour.
However as mentioned earlier malodours are complex and such approaches may not counter all the components of the malodour, so it is more likely that they modify the nature of the odour which again may be a worthwhile benefit but is only a partial solution to the problem.
Again the patent only teaches that aldehydes react with some malodorous molecules and there is no evidence for the prevention of biologically generated malodours.
Thus while it is apparent from the prior art that there are many methods which attempt to prevent malodour, none are completely satisfactory.

Method used

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  • Use of fragrance compositions for the prevention of the development of indole base malodours from fecal and urine based soils

Examples

Experimental program
Comparison scheme
Effect test

example 1

Identification of Active Fragrance Compounds

[0067]A sample of fresh human urine is divided into equal portions and a fragrance containing one or more of the effective materials was added as described in the Indole Inhibition Test. Control samples were prepared in which inactive compounds were substituted and a third unfragranced blank was also prepared to determine the suitability of the urine. The samples were stored and after 24 hours the indole content and fragrance active content is measured by gas chromatography with mass spectrometric (GCMS) detection. Those formulations containing active ingredients prevented the formation of indole while both the unfragranced and the alcohol containing control samples had much greater quantities of indole present. Also for the active compounds a GCMS measurement indicated the extent to which the compound was itself consumed as part of the process. In table 2 the decrease in fragrance components has been classified into 3 categories and the l...

example 2

Performance from a Liquid Rim Block

[0069]The active composition of Table 3 (example 2) was mixed into a liquid rimblock formulation having the composition of example 6 of which 0.25 g was added to 7.0 g of a fresh suitable human urine sample to give 0.02 g of active fragrance as described in part B of the indole inhibition test. After 24 hours the indole content was measured and the result shown as file URIN40.D in FIG. 1. Comparative example A control was mixed with the same liquid rim block formulation and gave the results in file URIN41.D in FIG. 1 while a blank sample containing 0.2 g of the liquid rim block formulation in urine gave file URIN39.D in FIG. 1. It can be seen the fragrance composition of the invention reduced indole concentration below 0.01 ppm (wt / wt). Note that the dosage of example 2 and comparative A in the liquid rim block represents about 30% of the normal total fragrance dose.

TABLE 3Effectiveness in a Liquid Rim Block - Formulation ofActive ComponentsExample...

example 3

[0070]Table 4 below demonstrates a fragrance composition according to the present invention containing 5% of active ingredient suitable for use in household products, along with a control fragrance comparative example B containing the corresponding inactive alcohols to the active aldehydes.

TABLE 4Example of Effective and Ineffective FragrancesExample 3Comparative Example BCompound%Compound%Benzaldehyde5Benzyl alcohol5Geraniol 98%20Geraniol 98%20Geranium oil Egypt nat2Geranium oil Egypt nat2Verdox5Verdox5Manzanate5Manzanate5Musk t-935Musk t-935Phenyl acetaldehyde10Phenyl ethyl alcohol10Phenyl ethyl alcohol42Phenyl ethyl alcohol42Phenylethylphenylacetate5Phenylethylphenylacetate5Rose oxide1Rose oxide1

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Abstract

The present invention relates to the use of fragrance compositions, said fragrance compositions comprising fragrance compounds selected among: aldehydes, α,β-unsaturated aldehydes, alcohols, ketones, and mixtures thereof in any home and personal care product, each fragrance compound being able to restrict the formation of indole to less than 0.01 ppm (wt / wt) after 24 hours incubation at room temperature in an airtight sealed vessel of suitable fresh human urine containing 0.28% by weight of each fragrance compound in order to prevent the development of indole based malodours from faecal and urine based soils.

Description

TECHNICAL FIELD OF INVENTION[0001]The invention relates to fragrances and fragrance ingredients which can be used in a variety of products to prevent the development of malodours derived from the action of micro-organisms on excreted matter such as urine or faeces. The present invention aims to prevent the creation of malodorous compounds based on indole and related compounds.BACKGROUND OF THE INVENTION[0002]Perfumes are used in many applications to mask malodours. A particularly important category of malodours are, for example, those resulting from substances transpired by or excreted by humans in particular perspiration, urine, faeces or menstrual fluid, and odours caused by animal urine or faeces, especially those of domestic pets.[0003]Malodours are usually caused by particularly odorous substances such as sulphur compounds e.g. hydrogen sulphide, and low molecular weight thiols and thioethers, nitrogen containing compounds such as ammonia and amines including heterocyclic compo...

Claims

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Application Information

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IPC IPC(8): A61K8/00
CPCA61K8/33A61Q13/00A61K8/35
Inventor WARR, JONATHAN FRANKBASSEREAU, MAUD BERNADETTEAUSSANT, EMMANUEL JULIENFRASER, STUART BERNARD
Owner TAKASAGO INTERNATIONAL CORPORATION
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