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Packaging Solutions

a technology for packaging solutions and ophthalmic devices, applied in the directions of transportation and packaging, detergent compounding agents, cleaning compositions of lenses, etc., can solve the problems of reducing shelf life and/or adverse reactions, limited use of surfactants in packaging solutions, and many people who wear contact lenses still experience dryness or eye irritation, so as to preserve the sterility of the solution and the ophthalmic devi

Inactive Publication Date: 2008-06-19
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for preparing a package of a sterile ophthalmic device by immersing it in an aqueous packaging solution containing hyaluronic acid or a salt thereof, and then packaging it in a way that prevents contamination. The solution has an osmolality of at least about 200 mOsm / kg and a pH of about 4 to about 9. The package is then heat sterilized. The invention also provides a packaging system for storing the ophthalmic device in the solution and a container for holding the solution and device. The technical effects of the invention are that it ensures the sterility and safety of the ophthalmic device during storage and preserves its functionality for use.

Problems solved by technology

Furthermore, the difficulties of adding a surfactant to a packaging solution, including the possibility of lowering shelf-life and / or adverse reactions during heat sterilization, have further limited the use of surfactants in a packaging solution for the purpose of providing any possible or marginal effect on lens comfort.
Nevertheless, many people who wear contact lenses still experience dryness or eye irritation throughout the day and particularly towards the end of the day.
An insufficiently wetted lens at any point in time will cause significant discomfort to the lens wearer.
However, the '687 patent nowhere provides any disclosure of the use of hyaluronic acid in a packaging solution.

Method used

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Examples

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example 1

[0076]Lens casting of a polyurethane-siloxane hydrogel formulation

[0077]Silicone hydrogel lenses were prepared from the monomer mixture set forth below in Table 1. The monomer mixture was filtered, cast between anterior and posterior polypropylene mold parts and then cured under UV for 1 hour. After being released from the molds, the lenses were extracted with isopropanol overnight, and then hydrated in deionized (DI) water.

TABLE 1FormulationPrepolymerExample 1I4D5S4H  53 parts by weightTRIS  15 parts by weightDMA   9 parts by weightHEMA   5 parts by weightNVP  24 parts by weightHEMAVC 1.3 parts by weightn-Hexanol  10 parts by weightD1173 0.5 parts by weightIMVT0.015 parts by weight

example 2

[0078]Surface treatment with hyaluronic acid sodium salt solution.

[0079]An aqueous solution containing 0.5% by weight of hyaluronic acid sodium salt (HA) (hyaluronic acid sodium salt from Streptococcus equi, commercially available from Fluka Biochemika, having a total impurity content of less than 1% protein and a solubility of 5 mg / ml in water) was prepared, and the pH was adjusted to 4 using dilute hydrochloric acid. The lenses prepared in accordance with Example 1 were then placed in glass vials, filled with the aqueous treating solution containing 0.5% by weight HA. Next, the lenses were autoclaved for 1 cycle (121° C., 30 minutes) and kept at 45° C. for 24 hours. The lenses were taken out and shaken with large amounts of DI water and then saved in a borate buffer saline for testing. The lenses thus obtained were visually examined and appeared more wettable than the control lens. The lenses were also rubbed between fingers and felt more lubricious than the control lens. The cont...

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Abstract

The present invention is directed to new and improved packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing an ophthalmic device in an aqueous packaging solution comprising hyaluronic acid or a salt thereof. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, thereby preventing dryness and improving lubricity.

Description

BACKGROUND OF THE INVENTION[0001]1. Technical Field[0002]The present invention generally relates to packaging solutions for ophthalmic devices such as contact lenses.[0003]2. Description of Related Art[0004]Blister-packs and glass vials are typically used to individually package each soft contact lens for sale to a customer. Saline or deionized water is commonly used to store the lens in the blister-packs, as mentioned in various patents related to the packaging or manufacturing of contact lenses. Because lens material may tend to stick to itself and to the lens package, packaging solutions for blister-packs have sometimes been formulated to reduce or eliminate lens folding and sticking. For this reason, polyvinyl alcohol (PVA) has been used in contact-lens packaging solutions.[0005]It has been stated that if a lens is thoroughly cleaned before insertion, lacrimal fluid can adequately wet the lens. Furthermore, the difficulties of adding a surfactant to a packaging solution, includi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B65B55/22B65B55/12B65B55/14B65D85/00
CPCA61L12/04C11D3/227C11D3/0078B65B25/008
Inventor LANG, WEIHONGLAI, YU-CHIN
Owner BAUSCH & LOMB INC
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