Modified diphtheria toxins

US20090010966A1Inactive Publication Date: 2009-01-08ANGELICA THERAPEUTICS
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
ANGELICA THERAPEUTICS
Publication Date
2009-01-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present application relates to compositions of modified diphtheria toxin and fusion proteins containing modified diphtheria toxin that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome, as well as methods of making the compositions. The present application also relates to a polypeptide toxophore from a modified diphtheria toxin, where the modification is at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of an unmodified native diphtheria toxin. Also described are fusion proteins which contain a modified diphtheria toxin and a non-diphtheria toxin fragment which contains a cell binding portion. The modified diphtheria toxins described can be used for the treatment of a malignant disease or a non-malignant disease.
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Description

CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 945,556, filed Jun. 21, 2007 (attorney docket number 33094-702.101), U.S. Provisional Application No. 60 / 954,278, filed Aug. 6, 2007 (attorney docket number 33094-702.102), U.S. Provisional Application No. 61 / 032,888, filed Feb. 29, 2008 (attorney docket number 33094-702.103), U.S. Provisional Application No. 61 / 042,178, filed Apr. 3, 2008 (attorney docket number 33094-702.104), U.S. Provisional Application No. 60 / 945,568, filed Jun. 21, 2007 (attorney docket number 33094-703.101), U.S. Provisional Application No. 60 / 954,284, filed Aug. 6, 2007 (attorney docket number 33094-703.102), U.S. Provisional Application No. 61 / 032,910, filed Feb. 29, 2008 (attorney docket number 33094-703.103), and U.S. Provisional Application No. 61 / 042,187, filed Apr. 3, 2008 (attorney docket number 33094-703.104), each of which applications is incorporated herein in its entirety by reference.BACKGROUND OF THE ...

Claims

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