Fortification of nutritional products with olive extracts containing hydroxytyrosol and hydroxytyrosol fortified nutritional products.

a technology of olive oil and nutritional products, which is applied in the direction of food ingredients as antioxidants, plant ingredients, biocides, etc., can solve the problems of heart attack, heart attack, and other symptoms, and achieve the effect of avoiding non-pleasant alterations of organoleptic properties

Inactive Publication Date: 2010-07-22
PROBELTE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0045]It is an aim of the present invention to solve the above mentioned problems and to provide fortified edible oil and/or oil-containing food products to be used as a source of hydroxytyrosol for preventi

Problems solved by technology

This makes it harder for blood to flow.
If the coronary arteries become narrow, blood flow to the heart can slow down or stop, causing chest pain (stable angina), shortness of breath, heart attack, and other symptoms.
This is a common cause of heart attack and stroke.
If the clot moves into the heart, lungs, or brain, it can cause a stroke, heart attack, or pulmonary embolism.
There is still a lot to be learned about metabolic syndrome, but doctors do know that people with metabolic syndrome have an increased risk of CVD.
The sensory aspect of these olive oils has great repercussions on its acceptability by consumers.
Summarizing, any way set up in order to increase antioxidant capacity using techniques based on fortification of olive oil with olive polyphenols, should not alter oils natural organoleptic characteristics, nor increase the amount of the bitter tasting olive polyphenols, otherwise incurring with the subsequent alteration of organoleptic properties of the oil, thus causing non-pleasant taste due to excessive bitterness, pungency and/or astringency, and subsequently causing rejection from many consumers.
The main problem connected with this process is associated with alteration of organoleptic properties of the vegetable oil, causing non-pleasant taste when excessive bitterness and/or astringency are produced in relation when oil increases its contents of polyphenols.
The main problem connected with methods disclosed in U.S. Pat. No. 6,942,890 and U.S. Pat. No. 6,162,480 is that only polyphenols that are fat soluble are (partly) extracted from olive solid matter or olives into oil.
Nevertheless, this method is scarcely effective: none of the patent examples shows that the prepared food compositions reach concentrations in the water phase higher than 50 ppm for hydroxytyrosol and tyrosol together.
The use of organic solvents, for example methanol that is a toxic solvent, is i

Method used

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  • Fortification of nutritional products with olive extracts containing hydroxytyrosol and hydroxytyrosol fortified nutritional products.
  • Fortification of nutritional products with olive extracts containing hydroxytyrosol and hydroxytyrosol fortified nutritional products.
  • Fortification of nutritional products with olive extracts containing hydroxytyrosol and hydroxytyrosol fortified nutritional products.

Examples

Experimental program
Comparison scheme
Effect test

example 1

Olive Extracts Production from Olives Fruits

[0093]25 Kg of a sample of olives fruits are mixed with 50 L of demineralised water. The obtained mixture is blended for a few minutes, and then 636 g of sulphuric acid (98%) were added. The obtained mixture is kept in autoclave at 15 psi (over the atmospheric pressure) for 30 minutes at 121° C. After that, the aqueous phase is separated from the solid residue, by filtering on a filter. The solid phase, retained on the filter, is washed with 12.5 L of demineralised water, and the water coming from this washing operation is collected with the aqueous phase previously recovered. The aqueous phase, approximately 56 L, is then centrifuge refined to eliminate solid particles passed through the filter. After solid elimination, 52 L of crude aqueous extract, containing 141 g of hydroxytyrosol, with a HPLC purity of 50.5%, are obtained.

[0094]Then, crude aqueous extract, is loaded on a chromatographic column containing an acid activated ion exchang...

example 2

Preparation of Olive Fruit Extract Powder by Spray-Drying

[0098]A sample of 260 ml of purified olive extract in liquid form containing 19.5 g of hydroxytyrosol obtained according to Example 1, is slowly stirred with 58 g of maltodextrin previously dissolved in 260 ml of demineralised water. For example, potato maltodextrin may be used. A peristaltic pump is used to feed the spray-dryer, which is previously equilibrated with an inlet air temperature of 150° C. The feeding speed is adjusted in order to obtain an outlet air temperature which is less than 100° C. 76 g of a white powder, with a moisture of 5.4% (Karl Fischer) and a hydroxytyrosol richness of 21.9% (w / w), are obtained.

example 3

Preparation of a Fortified Extra Virgin Olive Oil with Olive Fruit Extract

[0099]A sample of purified olive extract in liquid form containing a concentration of 40.6% (w / w) hydroxytyrosol obtained with a process according to Example 1, is selected for the fortification of a extra virgin olive oil. 6 samples, 400 g each, of such extra virgin olive oil were prepared. Increasing quantities of olive extract in liquid form are added in the weight ratio desired to the extra virgin olive oil and completely mixed, under very controlled parameters of temperature and agitation during 1 h. After that, stirring was switched off and mixture was filled into a decantation funnel and let settle down for 72 h. Then, the olive extract in excess has formed a bottom layer that is separated from the oil top phase to obtain the fortified extra virgin olive oil.

[0100]Straight afterwards, an aliquot of every one of the 6 samples of fortified extra virgin olive oil were used to measure antioxidant capacity (...

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Abstract

The present invention relates to nutritional products containing hydroxytyrosol, particularly fond products (i.e: fortified edible oils and fortified edible oil-containing products) and dietary supplements (i.e.: soft gel capsules containing fortified edible oils) with increased antioxidant capacity to be used as a source of hydroxytyrosol for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome, thanks to the nutritional supply of an hydroxytyrosol rich composition.

Description

FIELD OF THE INVENTION[0001]The present invention relates to fortification of nutritional products with olive extracts containing hydroxytyrosol; it also relates to hydroxytyrosol fortified nutritional products and to the use of both olive extracts and the nutritional products fortified with olive extracts for medical use, in particular for prevention or treatment of cardiovascular diseases (CVD), plaque build-up in the arteries, arterial hypertension, and metabolic syndrome.[0002]According to the invention, olive extract derived from olive fruit or olive oil extraction residues (pomace) is added to an edible oil and through this oil, to nutritional products, which results in an increase of the level of hydroxytyrosol. More particularly, the invention relates to the fortification of edible oil-containing products to be used as a source of hydroxytyrosol for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome,...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P9/00A61P9/12A61P3/04A61P3/06A61P9/10
CPCA23D7/005A23D7/0056A23D9/007A23V2002/00A61K31/05A61K36/63C11B5/0035C11B5/0085A23V2200/326A23V2250/21A23V2250/2132A23V2200/02A23L33/105A61P3/04A61P3/06A61P39/06A61P9/00A61P9/10A61P9/12
Inventor LOPES MAS, JOSE A.STREITENBERGER, SERGIO A.MELLADO, MARCOS PENALVERORTIZ, PEDRO MARTINEZ
Owner PROBELTE PHARMA
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