5, 6-ring annulated indole derivatives and use thereof

a technology of indole derivatives and ring annulations, which is applied in the direction of indole-indigos, phosphorous compound active ingredients, drug compositions, etc., can solve the problems of poor treatment effect, poor efficacy of hcv infection approaches, and hcv infection complications, etc., to achieve the effect of improving the safety and efficacy of treatment and improving the safety of treatmen
US20100322901A1Active Publication Date: 2010-12-23MERCK SHARP & DOHME CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MERCK SHARP & DOHME CORP
Publication Date
2010-12-23

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Abstract

The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to 5,6-ring annulated indole derivatives, compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.BACKGROUND OF THE INVENTION

[0002] HCV is a (+)-sense single-stranded RNA virus that has been implicated as the major causative agent in non-A, non-B hepatitis (NANBH). NANBH is distinguished from other types of viral-induced liver disease, such as hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis delta virus (HDV), as well as from other forms of liver disease such as alcoholism and primary biliary cirrhosis.

[0003] Hepatitis C virus is a member of the hepacivirus genus in the family Flaviviridae. It is the major causative agent of non-A, non-B viral hepatitis and is the major cause of transfusion-associated hepatitis and accounts for a significant proportio...

Claims

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