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System for noninvasive determination of alcohol in tissue

a tissue and alcohol technology, applied in the field of quantitative spectroscopy systems, can solve the problems of high signal-to-noise ratio and photometric accuracy requirements, and the large number of optically active substances that make up the tissue, and achieve the effects of high photometric accuracy, high optical throughput, and efficient collection

Inactive Publication Date: 2011-11-17
TRUTOUCH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The system provides accurate and precise non-invasive alcohol measurement, overcoming tissue spectral complexities and variability, with potential for commercial viability and clinical relevance.

Problems solved by technology

The design contends with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, calibration transfer problems plus a host of other issues.
In the 1.0 to 2.5 micron spectral region, the large number of optically active substances that make up the tissue complicate the measurement of any given substance due to the overlapped nature of their absorbance spectra.

Method used

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  • System for noninvasive determination of alcohol in tissue
  • System for noninvasive determination of alcohol in tissue
  • System for noninvasive determination of alcohol in tissue

Examples

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example embodiments

DESCRIPTION OF EXAMPLE EMBODIMENTS

[0177]In an example embodiment of the present invention (schematically depicted in FIG. 31), a noninvasive alcohol measurement system is comprised of 13 VCSEL's that are used to measure 22 discrete wavelengths. Table 1 shows a list of each VCSEL and the associated target peak wavelengths that will be interrogated during the course of the measurement. In this embodiment, each VCSEL is stabilized to a constant temperature. The peak wavelength of each VCSEL is controlled based on the circuit shown in FIG. 7 (each VCSEL having its own circuit), which also enables the VCSEL to be turned On and Off. The specific state (On / Off) of each VCSEL at a given time during a measurement is determined by a predetermined Hadamard matrix. In example embodiments incorporating solid state light sources the Hadamard matrix is a pattern of On / Off states versus time for each VCSEL that is stored in software rather than a physical mask or chopper. This allows the On / Off sta...

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Abstract

An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal- to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination / modulation subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Description

FIELD OF THE INVENTION[0001]The present invention generally relates to a quantitative spectroscopy system for measuring the presence or concentration of alcohol, alcohol byproducts, alcohol adducts, or substances of abuse utilizing non-invasive techniques in combination with multivariate analysis.BACKGROUND OF THE INVENTION[0002]Current practice for alcohol measurements is based upon either blood measurements or breath testing. Blood measurements define the gold standard for determining alcohol intoxication levels. However, blood measurements require either a venous or capillary sample and involve significant handling precautions in order to minimize health risks. Once extracted, the blood sample must be properly labeled and transported to a clinical laboratory or other suitable location where a clinical gas chromatograph is typically used to measure the blood alcohol level. Due to the invasiveness of the procedure and the amount of sample handling involved, blood alcohol measuremen...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/1455
CPCA61B5/0075G01N21/359A61B5/117A61B5/14546A61B5/1455A61B5/1495G01J3/02G01J3/0205G01J3/0218G01J3/0229G01J3/0291G01J3/14G01J2003/1286G01N21/274G01N21/474G01N2201/129A61B5/0088A61B5/4845A61B5/6826
Inventor RIDDER, TRENTVER STEEG, BENMILLS, MIKELAAKSONEN, BENTLEY
Owner TRUTOUCH TECH
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