Lactic Bacteria and Their Use in the Prevention of Diarrhea

a technology of lactic bacteria and aad, which is applied in the field of lactic bacteria strains in the prevention of diarrhea, can solve the problems of unavoidable development of effective preventive measures against aad, no bacterial strain has yet been shown to adhere in a permanent fashion, and the risk of aad not only for the patient undergoing antibiotic therapy, but also for the other patients, so as to prevent the occurrence of side effects, and prevent the aa side

Inactive Publication Date: 2012-05-03
BIO K PLUS INT
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0040]Another advantage of the present invention is that it provides a non toxic prevention or treatment of AAD.
[0041]A third advantage of the present invention is that it provides a non-invasive method of prevention or treatment of AAD.
[0042]Another advantage of the present invention is that it provides a method of prevention or treatment of AAD that does not require the use of antibiotics. This will prevent the occurrence of side effects caused by the incompatibility between drugs.
[0043]Another advantage of the present invention is also that it provides a composition that can be used over a prolonged period of time for prevention or treatment of AAD, which presents little or no side effects. Such composition is readily available in health food stores or specialized markets without the need for a prescription.
[0044]Another advantage of the present invention is that it provides a composition, which reaches the guts mucosa in a proper and viable form without getting destroyed in the upper part of the gastrointestinal tract, especially in the stomach. Another advantage of the present invention is that it also provides a composition, which contains a sufficient number of bacteria capable of getting implanted in the guts.
[0045]Another advantage of the present invention is that it provides a composition to be administered to adults and children alike. This composition can be administered in a hospital milieu, at home, in child-care facility or any facility where prevention and control of diarrhea is needed.

Problems solved by technology

It is observed that the development of a C. difficile AAD presents a risk not only for the patient undergoing antibiotic therapy, but also for the other patients hospitalized in the same care unit, given the contagious character of this diarrhea (Bartlett, 2002).
The development of effective preventive measures against AAD thus seems unavoidable.
On the other hand, no bacterial strain has yet been shown to adhere in a permanent fashion.
However, to this day the medical profession remains prudent as to the use of probiotics in common practice, partly because few studies with solid specifications supporting their efficiency in primary prevention of AAD have been published (Lewis et al., 1998).
Thus, the efficacy of probiotics in the prevention of AAD in adults shows conflicting results and needs to be further evaluated in adults.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lactic Bacteria and Their Use in the Prevention of Diarrhea
  • Lactic Bacteria and Their Use in the Prevention of Diarrhea
  • Lactic Bacteria and Their Use in the Prevention of Diarrhea

Examples

Experimental program
Comparison scheme
Effect test

example 1

Study Comparing the Efficacy of a Preparation of Lactobacillus (Bio-K+) to that of a Placebo in the Prevention of Antibiotic Associated Diarrhea

[0085]The study described in this example evaluates the utilisation of a preparation of Lactobacillus in a lactic ferment in primary prophylaxis of AAD. Consequently, a double blind, randomized, placebo controlled clinical study was realized. Two groups are compared in this study: the experimental group receiving the preparation of Lactobacillus and the control group receiving the placebo preparation: whey devoid of any bacterial strain.

Population Studied

[0086]The hospitalized adult patients at the Maisonneuve-Rosemont hospital in Montreal, QC, Canada, receiving an antibiotic treatment orally or parenterally for an estimated period of a minimum of 3 days, other than an aminoside or a vancomycine in monotherapy, were eligible for the study. The exclusion criteria included: refusal to participate, impossibility to obtain consent, incapacity to...

example 2

Efficacy of Probiotics in Solving an Outbreak of Severe Clostridium difficile Colitis at the Pierre-le Gardeur Hospital Centre

Introduction:

[0121]Clostridium difficile colitis is a frequent nosocomial infection in the Pierre-le Gardeur hospital centre (Montreal region, Quebec, Canada). Indeed, during the 2002-2003 fiscal year, the incidence was 9.5 cases / 1000 admissions. However, these infections, even the recurrent ones, did not present any severity and responded to a standard metronidazole or oral vancomycin treatment.

[0122]Between August and October 2003, there was nearly a 50% increase in the incidence of nosocomial cases with a severity and a mortality rarely encountered with this type of pathology. Furthermore, the response to the usual treatment was at times slow, and even without effect.

[0123]In November 2003, a series of measures to counter the situation were taken. The infected patients were isolated as a cohort with dedicated personnel. In addition, a more rigorous mainten...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
timeaaaaaaaaaa
Login to view more

Abstract

The present invention concerns a lactic composition useful for the prevention or treatment of diarrhea such as antibiotic associated diarrhea or “tourista.” The composition according to the invention contains at least a bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus acidophilus I-1492,Lactobacillus casei and a mixture of thereof.

Description

[0001]The present application is a divisional of U.S. Ser. No. 11 / 570,752, filed on Jun. 28, 2007, which is a national stage filing under 35 U.S.C. §371 of international application No. PCT / CA2005 / 000954, filed on Jun. 20, 2005, which claims the benefit of Canadian application No. 2,470,090, filed on Jun. 18, 2004. The entire contents of each of these priority applications are incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to the use of lactic bacteria strains in the prevention of diarrhea. More particularly, the present invention concerns the use of lactic bacteria in order to prevent antibiotic associated diarrhea (AAD).DESCRIPTION OF PRIOR ART[0003]Diarrhea may be caused by a temporary problem, like an infection, or a chronic problem, like an intestinal disease. A few of the more common causes of diarrhea are listed below:[0004]Bacterial infections: Several types of bacteria, consumed through contaminated food or water, can cause diarrh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/74A61P1/12A23L33/135A61K39/07A61P31/04
CPCA23V2002/00A23Y2220/17A61K35/747A23L33/135A61K2035/11A23V2200/32A23V2250/206A61P1/12A61P31/04A23V2400/125
Inventor LUQUET, FRANCOIS-MARIE
Owner BIO K PLUS INT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap