A kind of preparation method of Tripterygium wilfordii sustained-release microcapsules

A technology of sustained-release microcapsules and Tripterygium wilfordii, which is applied in the field of drug preparation, can solve the problems of limited clinical application and severe toxicity of tripterygium wilfordii, and achieve the effects of good slow-release speed, high embedding property, and reduced toxicity

Active Publication Date: 2021-05-07
SHAANXI INST OF INT TRADE & COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a preparation method of tripterygium wilfordii sustained-release microcapsules, which solves the problem in the prior art that the clinical application of tripterygium wilfordii is limited due to its relatively large toxicity

Method used

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  • A kind of preparation method of Tripterygium wilfordii sustained-release microcapsules
  • A kind of preparation method of Tripterygium wilfordii sustained-release microcapsules

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Embodiment 1

[0033] A preparation method of Tripterygium wilfordii sustained-release microcapsules, comprising the following steps:

[0034] Step 1, Purification of Triptolide Alcohol Extract

[0035] Step 1.1, raw material pretreatment: take triptolide alcohol extract with a purity of 95.2%, add ethanol equivalent to 5 times the weight of triptolide alcohol extract to it, stir to completely dissolve triptolide alcohol, and then add Glycine-hydrochloric acid buffer solution with a concentration of 0.05mol / L, adjust the pH value of the system to 4-5, and obtain the pretreated triptolide alcohol extract;

[0036] Step 1.2, Ultrasonic Synergy with Supercritical CO 2 Extraction: while the pretreated triptolide alcohol extract was treated with a power of 900W, the pretreated triptolide alcohol extract was subjected to supercritical CO with dichloromethane as a carrier. 2 Extracting, the extract is obtained after the extraction is completed, and the extract is concentrated and dried to obtain ...

Embodiment 2

[0047] A preparation method of Tripterygium wilfordii sustained-release microcapsules, comprising the following steps:

[0048] Step 1, Purification of Triptolide Alcohol Extract

[0049] Step 1.1, raw material pretreatment: take triptolide alcohol extract with a purity of 95.2%, add ethanol equivalent to 8 times the weight of triptolide alcohol extract to it, stir to completely dissolve triptolide alcohol, and then add Glycine-hydrochloric acid buffer solution with a concentration of 0.05mol / L, adjust the pH value of the system to 4-5, and obtain the pretreated triptolide alcohol extract;

[0050] Step 1.2, Ultrasonic Synergy with Supercritical CO 2 Extraction: while the pretreated triptolide alcohol extract was treated with a power of 1000W, the pretreated triptolide alcohol extract was subjected to supercritical CO with dichloromethane as a carrier. 2 Extracting, the extract is obtained after the extraction is completed, and the extract is concentrated and dried to obtain...

Embodiment 3

[0061] A preparation method of Tripterygium wilfordii sustained-release microcapsules, comprising the following steps:

[0062] Step 1, Purification of Triptolide Alcohol Extract

[0063] Step 1.1, raw material pretreatment: take triptolide alcohol extract with a purity of 95.2%, add ethanol equivalent to 10 times the weight of triptolide alcohol extract to it, stir to completely dissolve triptolide alcohol, and then add Glycine-hydrochloric acid buffer solution with a concentration of 0.05mol / L, adjust the pH value of the system to 4-5, and obtain the pretreated triptolide alcohol extract;

[0064] Step 1.2, Ultrasonic Synergy with Supercritical CO 2 Extraction: while the pretreated triptolide alcohol extract was treated with a power of 1200W, the pretreated triptolide alcohol extract was subjected to supercritical CO with dichloromethane as a carrier. 2 Extracting, the extract is obtained after the extraction is completed, and the extract is concentrated and dried to obtai...

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Abstract

The invention discloses a preparation method of tripterygium wilfordii sustained-release microcapsules, which comprises the steps of using ultrasonic waves to cooperate with supercritical CO 2 Extraction and high-pressure liquid chromatographic separation to purify the triptolide alcohol extract with a purity of about 95% to make it more than 99% pure; Microcapsules. The present invention reduces the impact of impurities on triptolide alcohol extract in drug treatment, and helps researchers to take effective measures to deal with the toxicity of triptolide alcohol extract; and the present invention has purified The alcohol extract of triptolide is microencapsulated, and the drug has high embedding property and good slow-release speed, which can slowly release the active ingredients in the drug, prolong the release, absorption and distribution of the drug in the body, thereby reducing the amount of triptolide Toxicity to humans.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation method of Tripterygium wilfordii sustained-release microcapsules. Background technique [0002] Tripterygium wilfordii is the root, leaf and flower of Tripterygium wilfordii, also known as Huangteng and Duanchangcao. Its nature and flavor are pungent and cool, and it is very poisonous. Modern pharmacological studies have shown that Tripterygium wilfordii has anti-inflammatory, analgesic, anti-tumor and immune regulation effects, and is often used in the treatment of skin inflammation, immune regulation, kidney disease and respiratory system diseases, but due to its large toxicity limit its clinical application. [0003] The medicinal ingredients in Tripterygium wilfordii are mainly diterpene lactones, triterpenoids, and alkaloids of tripterygium wilfordii, among which triptolide, also known as triptolide, belongs to diterpene lactones. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/38A61K47/36A61K47/10A61K31/585A61K36/37C07J73/00
CPCA61K9/5031A61K9/5036A61K9/5042A61K31/585A61K36/37A61K2236/33A61K2236/37A61K2236/55C07J73/003Y02P20/54
Inventor 丁芳芳景涛
Owner SHAANXI INST OF INT TRADE & COMMERCE
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