Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate

a technology of flupirtine maleate and polymorphic forms, which is applied in the field of new polymorphic forms of flupirtine maleate, can solve the problems of affecting the quality, safety and efficacy of a drug product, and achieve the effect of improving the safety and efficacy of the drug produ

Inactive Publication Date: 2012-06-07
PLIVA HRVATSKA D O O
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]There is now provided by the present invention, therefore, polymorphic forms of the pha

Problems solved by technology

Thus, polymorphism can affect the quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate
  • Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate
  • Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Flupirtine Maleate Form I

[0071]250 mg of flupirtine maleate was dissolved in 35 mL of methyl acetate whilst heating. Hot solution was filtered and crystallisation of needle like crystals occurred while cooling the solution to room temperature. The product was collected by filtration and dried overnight at room temperature. 136 mg of a white crystalline product was obtained.

example 2

Preparation of Flupirtine Maleate Form II

[0072]500 mg of flupirtine maleate was placed in 3-neck round bottom flask filled with a mixture of 96% ethanol (15 mL) and dichloromethane (30 mL). The reaction mixture was refluxed for 20 minutes whilst stirring and then cooled in an ice bath to room temperature. Stirring was then continued at room temperature overnight. The product was filtered and dried overnight at room temperature. 314 mg of a white product was obtained.

example 3

Preparation of Flupirtine Maleate Form III

[0073]500 mg of flupirtine maleate was dissolved in 10 mL of 96% ethanol. The solution was heated and the hot solution was filtered and added dropwise to 20 mL of hot methyl acetate. The mixture was stirred at room temperature and precipitation of a crystalline product occurred. The product was filtered. 320 mg of a white product was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Angleaaaaaaaaaa
Angleaaaaaaaaaa
Angleaaaaaaaaaa
Login to view more

Abstract

New polymorphic forms of flupirtine maleate are described.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. Nonprovisional patent application Ser. No. 12 / 309,260, filed Mar. 25, 2011, which is a National Stage Application of PCT / GB2007 / 002647, filed Jul. 13, 2007, which claims benefit of Serial No. 0613928.1, filed Jul. 13, 2006 in Great Britain and which applications are incorporated herein by reference. To the extent appropriate, a claim of priority is made to each of the above disclosured applications.FIELD OF THE INVENTION[0002]The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical compositions containing them, therapeutic uses thereof and methods of treatment employing them.BACKGROUND OF THE INVENTION[0003]Flupirtine maleate is chemically designated 2-amino-3-carbethoxyamino-6,4-fluorobenzylamino-pyridine maleate and can be represented by the following structural formula:[0004]Flupirtine is a centrally ac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/44A61P21/02A61P25/16A61P29/00C07D213/75A61P25/00
CPCC07D213/75A61P21/02A61P25/00A61P25/04A61P25/16A61P25/28A61P29/00
Inventor DANILOVSKI, ALEKSANDARDEVCIC, MAJAMARINKOVIC, MARINAMESTROVIC, ERNESTMUNDORFER, TINATUNJIC, IVA
Owner PLIVA HRVATSKA D O O
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap