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Film forming polymer compositions for boosting spf in sunscreens

a technology of spf and composition, which is applied in the direction of drug compositions, toilet preparations, dermatological disorders, etc., can solve the problems that the amount of film forming polymers can have a deleterious effect on the feel of the composition on the skin, and achieve the effects of reducing the deleterious effects of uv radiation, preventing or reducing the occurrence of erythema, and preventing or reducing the occurrence of phototoxic or photoallergic reactions

Inactive Publication Date: 2012-08-02
BAYER HEALTHCARE LLC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a composition that can protect the skin from UV radiation and increase the level of protection provided by sunscreen active agents. This is achieved by adding a film forming polymer containing acid groups to an aqueous solvent-based composition, and then neutralizing some of the acid groups with a neutralizing agent. The resulting composition has improved stability and can be used to protect the skin from UV radiation-related skin damage, such as sunburn, skin redness, and skin allergic reactions. The invention also provides a method for increasing the level of protection provided by sunscreen active agents in a composition.

Problems solved by technology

However, it has been determined that the addition of the film forming polymers beyond a certain amount can have a deleterious effect on the feel of the composition on the skin, in particular providing a caking feeling.

Method used

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  • Film forming polymer compositions for boosting spf in sunscreens
  • Film forming polymer compositions for boosting spf in sunscreens
  • Film forming polymer compositions for boosting spf in sunscreens

Examples

Experimental program
Comparison scheme
Effect test

example 1

Sunscreen Composition

[0054]A sunscreen composition was prepared containing amine neutralizing agents and film forming polymer as follows. To a 250 ml beaker was added 3.0 g Avobenzone, 5.0 g Octisalate, 6.0 g Oxybenzone, 15.0 g Homosalate, and 1.0 g of Glycerine to a stirred solution containing 0.51 g of Dimethylstearylamine and 3.0 g of Dermacryl 79 (an acrylate copolymer containing 14% acrylic acid, available from National Starch and Chemical Co. Bridgewater, N.J.) in 66.49 g of Ethanol. The composition was stirred until all components are dissolved. Similar compositions can be heated slightly to aid in dissolution.

example 2

Evaluation of Effect of Neutralization on SPF of Sunscreen Formulations

[0055]Sunscreen compositions were prepared as described above with varying levels and types of amine neutralizing agents. All compositions in this example contained Avobenzone (3.0 g), Octyl Salicylate (5.0 g), Oxybenzone (6.0 g), Homosalate (15.0 g), glycerin (1.0 g) and Dermacryl 79 (3.0 g) plus ethanol to bring the weight to 100 g.

[0056]All SPF measurements were conducted using poly(methyl methacrylate) (PMMA) plates (Schonberg GMBH & Co KG., 22457 Hamburg-Schnelsen, Germany) as the substrate to which the sunscreen formulas were applied. Test formulations were applied to the substrates at 1 mg / cm2 and allowed to dry for 20 minutes. A PMMA plate treated with glycerin at 1 mg / cm2 served as a reference and blank. The in vitro SPF of each formula was determined using an Optometries SPF 290S Analzyer (Optometries LLC, Ayer, Mass.; USA) equipped with a computer-controlled X-Y sampling stage and operated according to...

example 3

Various Amines Used for SPF Boost

[0059]Sunscreens were prepared as described in Example 2 to which the indicated amines (Table 3) were added in an amount to neutralize 25 percent of the carboxylic acid groups on the Dermacryl 79. Test formulations were applied to the PMMA substrate at 2 mg / cm2 and analyzed for SPF performance. The results are shown in Table 3:

TABLE 3Sample #AmineSPF11Propylamine4512Butylamine5313Hexylamine8214Octylamine10215Decylamine9316Dodecylamine7617Diethylamine6318Dihexylamime8119Triethylamine5420Tributylamine2521Dimethylaminopropylcocamide6922Cocamine8323Dimethylcocamine5224Dimethylstearylamine6525Soyamine6426Dimethylsoyamine6327Dimethylerucylamine8328Dimethylbehenylamine6229PEG-15 Cocamine5630PEG-15 Soyamine6331PEG-2 Behenylamine7132Jeffamine M-10005733Jeffamine M-20703934Control no neutralizer39

Sample 34 represents the control with no neutralization. These experiments show that, although compositions containing certain of the amines do not demonstrate, a sub...

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Abstract

Film-forming compositions comprising a film forming polymer containing acid groups and a neutralizing agent; compositions and methods for increasing the SPF of a composition by neutralizing at least a portion of the acid groups of the film forming agent with the neutralizing agent.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of U.S. application Ser. No. 12 / 628,924, filed Dec. 1, 2009, which claims priority to U.S. application Ser. No 61 / 172,916, filed Apr. 27, 2009, and to EP 09163327.1, filed Jun. 22, 2009, the contents of which are each hereby incorporated by reference into this specification in its entirety.FIELD OF INVENTION[0002]This invention relates generally to compositions-applied topically to surfaces, for example skin and hair, for protection against ultraviolet radiation. The invention also relates to compositions and methods to improve skin feel and sunscreen in g capacity of such compositions.BACKGROUND OF THE INVENTION[0003]Sunscreen compositions are typically categorized as either aqueous or non-aqueous, i.e., anhydrous, compositions. Aqueous sunscreen compositions are typically creams formed as emulsions containing the active UV absorbing compounds and additional ingredients such as waterproofing...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/81A61Q17/04
CPCA61K8/046A61K8/35A61K8/37A61K8/8147A61K2800/31A61Q17/04A61K8/45A61K8/86A61K8/41A61K8/42A61P17/16
Inventor HE, QIWEIPHILBIN, MICHAEL T.MARTINO, GARY T.MEYER, THOMAS A.BEASLEY, DONATHAN G.WAGNER, JR., JOHN H.
Owner BAYER HEALTHCARE LLC