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Biopharmaceutical process apparatuses assembled into a column

Inactive Publication Date: 2013-08-01
STOBBE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes an apparatus that can be sterilized and used only once, which eliminates the need for cleaning and validation steps associated with stainless steel equipment. The flexible design of the apparatus allows for faster evaluation and easy modification to fit different requirements. Overall, this eliminates costs associated with cleaning, assembly, and disassembly, and allows for faster and more cost-effective biotech process design.

Problems solved by technology

The device has no integration of any Down-Stream devices or second circulation pump.
However problems remains the future hurdles to overcome and include the ability to add reliable, accurate sensors and pumping devices so that standards can be generated and the process repeatability readily documented.
Presently none of the traditional technical devices for single-use production system supplied to the Biopharmaceutical Process Plants facilitate the desired integration or modularity.
This fact excludes the option of compact integration of both Up-Stream and Down-Stream process equipment, which lack of integration demands expensive and extended facilities.

Method used

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  • Biopharmaceutical process apparatuses assembled into a column
  • Biopharmaceutical process apparatuses assembled into a column
  • Biopharmaceutical process apparatuses assembled into a column

Examples

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Embodiment Construction

[0116]In one aspect the present invention relates to a bioreactor apparatus having a top capsule and a bottom capsule, the apparatus comprising a cultivation capsule having a production device for producing a biologic product, and a second upstream capsule, wherein said capsules are stacked and locked in a column, with the proviso that the top capsule and bottom capsule are not pump capsules at the same time.

[0117]Thus, the top capsule may be a cultivation capsule and the bottom capsule may be the second upstream capsule or may be the third or so forth capsule. Alternatively, the cultivation capsule may be located between the top and bottom capsules and may consist of one or more cultivation capsules.

[0118]The bioreactor apparatus is preferably for single use, or is pre-sterilized or both. The bioreactor may be any suitable bioreactor, such as a bioreactor selected from a batch, fed-batch, or continuous mode, e.g. continuous perfusion.

[0119]The bioreactor may be connected to a purif...

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Abstract

A bio factory apparatus capable of Up-Stream production of biologic material products or biologics products in a liquid volume and processing of biologic or biologic material products Down-Stream, comprising at least one first Up-Stream producing capsule and at least one second Down-Stream processing capsule, said capsules capable of being stacked in any order and any number within a column.

Description

TECHNICAL FIELD[0001]The present invention relates to a cultivation apparatus for production of a biologic product, a purification apparatus for purifying a biological product and a bio factory apparatus assembly for producing a purified biologic product. The Up-Stream production is performed by micro organism kept productive in a bioreactor after which the produced crude biologic product is forwarded to Down-Stream processing with various separation methods by numerous technical devices. The invention allows for multiple steps of the production and / or processes to be place in one and same flexible manufacturing apparatus operating in at least one column.BACKGROUND OF THE INVENTION[0002]EP 317874A2 describes a method for continuous production and removal of a biological substance. This is depending on externally separation devices arranged outside the hollow-fibre bioreactor and not integrated within the bioreactor column. There are no pumps integrated into the producing apparatus.[...

Claims

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Application Information

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IPC IPC(8): C12M1/00B01D27/14C12N9/00C12N5/074C12P21/00C12P19/04
CPCC12M23/34C12M23/42C12M23/44C12M25/14C12M29/04C12M29/10C12M25/18C12M47/10C12N5/0607C12N9/00C12P19/04C12P21/00B01D27/14
Inventor STROBBE, PER
Owner STOBBE TECH
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