Treatment of ocular inflammatory diseases using laquinimod
a technology of ocular inflammatory diseases and laquinimod, which is applied in the direction of biocide, immunological disorders, drug compositions, etc., can solve problems such as permanent vision loss, and achieve the effect of high oral bioavailability
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experimental examples
Example 1
Evaluation of Efficacy Following Daily Topical Administration of Laquinimod In S-Antigen-Induced Experimental Autoimmune Uveitis in Rats (EAU Model)
[0068]General.
[0069]A 1% (10 mg / ml) and a 5% (50 mg / ml) solution of laquinimod sodium were prepared in sterile water. Dissolution of laquinimod powder was achieved by shaking, stirring, or low-speed vortex. The solutions were stored for up to 2 weeks at 2-8° C. and up to 24 hours at room temperature. Laquinimod solutions were prepared under light protection and were protected from light for the duration of the experiment. Cyclosporine A was used as a reference material at a concentration of 25 mg / kg / j (Fluka). One 100 mg / 4 ml in olive oil dose was prepared every 2 days and stored at room temperature.
[0070]Animals and Animal Husbandry.
[0071]Thirty two (32) female albino Lewis rats, approximately 8 weeks old, were used for this study. All rats were held in observation for at least 3 days to monitor for signs of ill health or ocula...
example 2
Evaluation of Ocular Active Anaphylaxis Reduction Following Topical Ocular Administration Of Laquinimod in Mice (Late Phase) Using Ovalbumin Model
[0085]General.
[0086]Laquinimod solutions were prepared as in Example 1.
[0087]Animals and Animal Husbandry.
[0088]Forty (40) male Balb / c albino mice were used for this experiment. The mice were about 7-8 weeks old upon ordering, and were held in observation for at least three (3) days to monitor for signs of ill health or ocular abnormalities. Only healthy animals were accepted for use in this study. The rats were housed under identical environmental conditions, with a relative humidity of 55%±10%, continuous ventilation, and an automatic 12 hour light / dark cycle. Environmental conditions were continuously controlled and recorded. Animals had free access to food and water.
[0089]Materials and Methods.
[0090]Forty (40) Balb / c albino mice were randomly allocated to five groups of eight animals each. Only the right eyes of each animal were used i...
example 3
Dose Conversion Between Species
[0109]The National Institutes of Health (NIH) provides a table of Equivalent Surface Area Dosage Conversion Factors below (Table 8) which provides conversion factors that account for surface area to weight ratios between species.
TABLE 8Equivalent Surface Area Dosage Conversion FactorsToMouseMonkey20 gRat 150 g3 kgDog 8 kgMan 60 kgFROMMouse1½¼⅙ 1 / 12Rat21½¼ 1 / 7Monkey421⅗⅓Dog641⅔1½Man127321
[0110]In the examples 4-9 below, the administration of the composition is once daily. The administration can be repeated daily for a period of one, two, three or four days, up to 14 days, or longer as necessary.
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