Pharmaceutical composition containing a mixture of proenzymes and enzymes

Abstract

Pharmaceutical composition containing a mixture of proenzymes and enzymes, containing proenzymes trypsinogen and chymotrypsinogen and enzymes ct-amylase and lipase as active substances, and one or more pharmaceutically acceptable excipients, for simultaneous, separate and subsequent administration of the composition in parenteral or transmucosal way, the composition has anti-proliferative and anti-metastatic effects to cancer tumours and is intended for therapeutic, prophylactic and anti-metastatic use in mammals.

Description

TECHNICAL FIELD[0001]The invention deals with new pharmaceutical compositions containing a mixture of proenzymes and enzymes having anti-proliferative and anti-metastatic effects.BACKGROUND ART[0002]Malignant neoplastic diseases represent a vast group of diseases that are one of the worst curable death causes. They cause 13 percent of deaths per year recently. (Jemal A. et al., CA: Cancer J. Clinic., 61, 2011, 69-90.). Occurrence of malignant tumours brings dangers given by the ability of tumour cells to change adjacent cells while new blood vessels, further supporting cells and metastases are produced.[0003]Anti-neoplastic pharmacotherapy is an important part of large spectrum of present treatment approaches. In terms of therapeutic position pharmacotherapy of neoplastic diseases is divided to adjuvant (affecting so called residual disease e.g. after a surgical operation), non-adjuvant (preceding operation and radiation treatment, aimed at tumour devitalisation and inhibition) and ...

AI Technical Summary

Benefits of technology

[0010]Human carcinomas occur as subsequence of various factors and their cells themselves further influence cellular signalling and paths regulating cellular proliferation and the time of survival of the other cells. Complex cellular signalling in a cancer cell is modified, the number of stimuli that tumours react to decreases, but the reaction intensity increases. This represents the base of increased sensitivity of tumours to genotoxic stresses and immune influences (O'Driscoll, L., Cur. Cancer Drug Targets 9, 2009, 250-251).

[0011]Cancer treatment success varies a lot today depending on particular malignity type. Some types of cancer diseases, e.g. testicular seminoma, infant leukaemia, and some lymfoms are very sensitive to anti-neoplastic treatment (Gonzalez-Angulo, A. M et al., Adv. Exp. Med. Biol., 608, 2007, 1-22). Other malignant cancer diseases show a limited response only (if any) and no efficient therapy is available against them now. (Jemal, A. et al., CA Cancer J. Clin., 60, 2010, 277-300). In the instances of advanced tumours with developed metastases, chemotherapy remains palliative treatment in better cases. If we define success rate of present pharmacotherapy by the survival time of cancer patients, we find that this essential parameter of treatment factually has nearly not changed for the last 30 years. Achieved success has actually to be attributed to timely diagnostics (Hemminki, K., Annals Oncol., 23, 2012, 760-764). Moreover, most of the clinically approved anti-neoplastic medicines are characterized by narrow therapeutic window, which is particularly related to their high systemic toxicity (Lowenthal, R. M.; Eaton, K., Hematol. Oncol. Clin. North Am., 10, 1996, 967-90).

[0012]Resistance against anti-neoplastic medicines represents another serious problem, particularly in long-term treatment (Redmond, K. M. et al.: Front. Biosci., 13, 2008, 5138-5154), whether based internally in tumour cells (intrinsic resistivity) or it is acquired. Multiple resistance against higher number of anti-neoplastic substances, often of different structures and functions, appears more and more often (Wu, Ch.-P. et al.; Curr. Pharm. Biotechnol., 12, 2011, 609-620). This clinical resistance is multifactorial and heterogeneous with numerous molecular mechanisms. (Glickman, M. S., Sawyers, C., Cell 148, 2012, 1089-98). Relatively short history of targeted biological cancer treat

Problems solved by technology

Occurrence of malignant tumours brings dangers given by the ability of tumour cells to change adjacent cells while new blood vessels, further supporting cells and metastases are produced.

We can add in general that any intervention in such a complicated and still little known system always leads to some consequences, which are however not always known or predictable or positive.

Other malignant cancer diseases show a limited response only (if any) and no efficient therapy is available against them now.

Moreover, most of the clinically approved anti-neoplastic medicines are characterized by narrow therapeutic window, which is particularly related to their high s

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