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Method and compositions for improving selective catabolysis in cells of keratin surfaces

a technology of keratin surface and selective catabolysis, which is applied in the field of compositions for improving selective catabolysis in keratin surface cells, can solve the problems of skin damage, accelerated appearance of aging, and damage to cellular dna, mitochondria, lipids,

Active Publication Date: 2019-07-04
ELC MANAGEMENT LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a composition and a method for treating keratin surfaces to stimulate the breakdown of proteins. This composition includes both a proteasome activator and an autophagy activator. The technical effects of this patent are the improvement of skin appearance and the reduction of skin tightness and flapping.

Problems solved by technology

It is well known that stress and environmental aggressors such as UV light, pollution, and cigarette smoke can be very detrimental to skin and accelerate the appearance of aging.
Exposure to stress and environmental aggressors often causes damage to cellular DNA, mitochondria, and cellular proteins, lipids, and tissue.
Damaged cellular material found within the cell, for example, cytoplasmic or organelle debris can exert a toxic effect on cells by impeding their normal metabolic processes.
When cells become damaged, either by UV exposure or environmental assaults, the proteasomes lose effectiveness.

Method used

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  • Method and compositions for improving selective catabolysis in cells of keratin surfaces
  • Method and compositions for improving selective catabolysis in cells of keratin surfaces
  • Method and compositions for improving selective catabolysis in cells of keratin surfaces

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0158]Normal human dermal fibroblasts from 42 and 62 year old female donors were harvested and assayed for cellular viability when untreated, treated with 0.01% of proteasome activator (hydrolyzed algin-Phyko A1), 2% autophagy activator in the form of yeast extract, and a combination of 0.01% proteasome activator and 2% autophagy activator.

[0159]The fibroblasts were placed in concentrations of 150,000 cells per plate for the 48 hour test, and 300,000 cells per plate for the 24 hour test on 96 well plates. The cells were incubated at 37° C., 5% CO2, and 95% humidity for 24 hours. The test compositions were prepared as follows:

(a) 2% Yeast Extract: The composition was prepared by combining 160 μl of yeast extract and 7.760 milliliters of Dulbecco's Modified Eagle Media (DMEM).

(b) 0.01% Hydrolyzed Algin: 1% solution of hydrolyzed algin was prepared by dissolving 0.01 grams in 10 ml of DMEM. Then 80 μl of this hydrolyzed algin solution was further diluted with 7.760 ml DMEM extract and ...

example 2

[0164]A skin treatment composition in accordance with the invention was prepared as follows:

Ingredientw / w %Oleth-3 phosphate0.45Oleth-30.35Oleth-50.24Butylene glycol0.20Squalane0.50BHT0.10Ethylhexyl methoxycinnamate0.10Choleth-24 / ceteth-240.10Triethanolamine0.11Retinyl palmitate / zea mays (corn) oil / BHT / BHA0.10Butylene glycol1.1Chamomile0.03Bisabolol0.10WaterQSMethyl paraben0.46PEG-754.00Bis-PEG-18 methyl ether dimethyl silane2.00Glycereth-261.00Methyl gluceth-204.00Trisodium EDTA0.10Pantethine0.14Caffeine0.05Xanthan gum0.075Carbomer0.26Triethanolamine0.50Phenoxyethanol0.70Benzyl alcohol0.10Bifida ferment lysate9.40Water / bifida ferment lysate / hydrogenated lecithin3.00Butylene glycol / water / Cola Acuminata extract3.00Sodium ribonucleic acid0.01Water / butylene glycol / tripeptide-32*0.20Lactobacillus ferment / lecithin / water0.05Water / Arabidopsis Thaliana extract / lecithin0.05Phenoxyethanol0.02Sodium hyaluronate0.01FD&C Red No. 4 (1% aqueous solution with butylene glycol)0.04FD&C Yellow No. 5 (...

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PUM

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Abstract

A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.

Description

RELATED APPLICATIONS[0001]This application claims priority from provisional patent application Ser. No. 61 / 701,130 filed Sep. 14, 2012.TECHNICAL FIELD[0002]The invention is in the field of compositions for application to skin which enhance selective catabolysis in skin cells.BACKGROUND OF THE INVENTION[0003]It is well known that stress and environmental aggressors such as UV light, pollution, and cigarette smoke can be very detrimental to skin and accelerate the appearance of aging. Exposure to stress and environmental aggressors often causes damage to cellular DNA, mitochondria, and cellular proteins, lipids, and tissue. Damaged cellular material found within the cell, for example, cytoplasmic or organelle debris can exert a toxic effect on cells by impeding their normal metabolic processes.[0004]Healthy cells have a normal cleansing process that eliminates damaged cellular material and debris. Such detoxification often occurs through a phagocytic process referred to as autophagy, ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/99A61K8/64A61K8/66A61Q19/08A61Q19/00
CPCA61K8/99A61K8/64A61Q19/00A61Q19/08A61K8/66A61K8/9728
Inventor PERNODET, NADINE A.DONG, KELLYPELLE, EDWARDYAROSH, DANIEL B.
Owner ELC MANAGEMENT LLC
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