Treating Auto-Immune and Auto-Inflammatory Diseases
a technology for auto-immune and auto-inflammatory diseases, applied in the direction of pharmaceutical delivery mechanism, powder delivery, medical preparations, etc., can solve the problems of reduced t cell responsiveness to gcs, high risk of developing very serious side effects, and complex contextual dependence of gc signaling mechanism, so as to restore corticosteroid sensitivity and enhance glucocorticoid sensitivity
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lass="d_n">[0069]According to various embodiments, a method of treatment using a pharmaceutical formulation comprising 17-OHPC has shown to be effective in two specific mechanisms: lowering IL-17 levels and inhibiting p38 MAPK activity. Both actions have a therapeutic effect in treating IL-17 and p38 MAPK mediated glucocorticoid resistance. Such a result is surprising given that previous studies using P4 had contrary results.
[0070]P4 and 17-OHPC are both classified as progestogen hormones. P4 is a naturally occurring progestogen endogenous to living organisms and may be considered as the chemical equivalent of a genus. P4 is synthesized within the ovaries, testes, placenta, and adrenal gland. Whereas 17-OHPC is a progestin (a synthetic progestogen) derived from 17α-hydroxyprogesterone (17-OHP) and caproic acid.
[0071]Structurally, progesterone (molecular weight (MW) of 314.46 g / mol and a melting point of 129.5° C.) and 17-OHPC (MW 428.6 g / mol and a melting point of 119° C.) and proge...
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