Aqueous lysine-containing animal feed supplements and process for the production thereof

a technology of animal feed and lysine, which is applied in the field of lysine-containing animal feed supplements and process for the production thereof, can solve the problems of undesirable dust development, impairing the shelf life and dispensing properties of products, and solid product types often exhibit clear disadvantages in handling properties and applications, etc., and achieves economic and efficient effects

Inactive Publication Date: 2002-10-15
EVONIK OPERATIONS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The object of the invention is to provide novel, aqueous preparations of L-lysine and its salts suitable as a feed supplement. In addition, it is an object of the invention to provide a production process that is more economical and efficient than processes currently known.

Problems solved by technology

These types of solid products often exhibit clear disadvantages with regard to handling properties and application.
For example, the quality of the product may be influenced to a considerable extent by the weather (high air humidity levels may cause caking which impairs the shelf life and dispensing properties of the product).
In addition, the processing of dry, pulverulent L-lysine-containing products may lead to undesirable dust development.
One problem with this is that, in addition to L-lysine, various other cations are present in the fermentation broth which are also bound.
The disadvantage of these two preparation methods lies in the numerous individual stages and the complex cleaning processes using ion-exchange chromatography.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Production of an L-lysine-Containing Fermentation Broth

Fermentation processes for producing lysine-containing broths, which are worked up according to the invention, have been described in detail in various prior patents (EP-B 0 532 867 and U.S. Pat. No. 5,840,551).

example 2

Production of a Biomass-Free Product

20 kg of a fermentation broth with a lysine content of approximately 9.5 wt. % (as lysine base) were produced in accordance with Example 1. The biomass present in the fermentation broth was first inactivated by heat treatment for 30 minutes at 80.degree. C. The inactivated biomass was then separated off by centrifuging for 20 minutes at 4000 rpm (Biofuge-Stratos laboratory centrifuge, Heraeus, Dusseldorf, Germany). 1.0 L of the supernatant purified in this way was adjusted to a pH value of approximately 4 by the stepwise addition of concentrated sulfuric acid. The liquid content of the centrifugate was then reduced under vacuum using a rotary evaporator (Buchi Rotavapor RE-120 laboratory rotary evaporator, Buchi-Labortechnik GmbH, Konstanz, Germany) to approximately 50% dry matter content.

The liquid product obtained in this way had an L-lysine content of 31.5 wt. % (as lysine base) and a pH value of 4. The total solids amounted to 49.3 wt. %.

example 3

Production of a Biomass-Containing Product

20 kg of a fermentation broth with a lysine content of approximately 9.5 wt. % (as lysine base) were produced in accordance with Example 1. The biomass present in the fermentation broth was inactivated directly in a bioreactor by heat treatment for 30 minutes at 80.degree. C. 1.0 L of this biomass-containing fermentation broth then was adjusted to a pH value of approximately 4 by the stepwise addition of concentrated sulfuric acid. The liquid content of this acidic lysine-containing fermentation broth was then reduced under vacuum using a rotary evaporator (Buchi Rotavapor RE-120 laboratory rotary Evaporator, Buchi-Labortechnik GmbH, Konstanz, Germany) to approximately 50% dry matter content.

The liquid product obtained in this way had an L-lysine content of 21.8 wt. % (as lysine base) and a pH value of 4. The total solids amounted to 50.7 wt. %. No significant change in content was noted after 16 months storage at 20.degree. C.

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PUM

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Abstract

The invention relates to aqueous L-lysine-containing animal feed supplements, which optionally contain inactivated microorganisms from fermentation and have a pH value greater than 4 and less than 5 and to a process for producing this preparation.

Description

The invention relates to aqueous L-lysine-containing animal feed supplements, which optionally inactivated microorganisms from the fermentation process, and a process for the production of such supplements.The essential amino acid L-lysine is widely used as an animal feed supplement. It is known that L-lysine is produced by fermentation of strains of coryneform bacteria, in particular Corynebacterium glutamicum. Due to its great significance, efforts are constantly being made to improve the production process. Improvements to the process may relate to the intrinsic performance characteristics of the microorganisms (e.g., by mutagenesis and selection), to measures concerning fermentation technology (e.g., stirring and oxygen supply), to the composition of the nutrient media (e.g., sugar concentration during fermentation), or to ways in which product is purified or prepared (e.g., ion exchange chromatography or crystallisation.According to the prior art, there are three different grou...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A23K1/00A23K1/16A23K1/175
CPCA23K1/006A23K1/007A23K1/1634Y10S426/807A23K10/10A23K10/12A23K20/142
Inventor BINDER, MICHAELUFFMANN, KLAUS-ERICH
Owner EVONIK OPERATIONS GMBH
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