Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of pullulan as a slowly digested carbohydrate

Inactive Publication Date: 2005-07-12
ABBOTT LAB INC
View PDF6 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]The discovery of this mischaracterization means that applicants have discovered a number of new uses for pullulan. As a slowly digested carbohydrate, substantial quantities of the pullulan may be incorporated into foods designed for diabetics, thereby providing a blunted glycemic respons

Problems solved by technology

However, over the years researchers found that low-carbohydrate, highfat diets were associated with dyslipidemias and cardiovascular disease.
Thus, while the literature teaches that pullulan may have efficacy as a fiber, it would not motivate one to use pullulan as slowly digested carbohydrate.
The prior art teaches that such a use would be futile because humans are incapable of converting pullulan to glucose or other simple sugars.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of pullulan as a slowly digested carbohydrate
  • Use of pullulan as a slowly digested carbohydrate
  • Use of pullulan as a slowly digested carbohydrate

Examples

Experimental program
Comparison scheme
Effect test

example i

OF THE INVENTION

[0073]One method of screening carbohydrates for their suitability for inclusion into diabetic diets is to determine the rate at which they are digested by animal or human enzymes in an in-vitro model of digestion. This technique is well known in the art and has been described by Muir and O'Dea at American Journal of Clinical Nutritional (1992) 56:123-127 and American Journal of Clinical Nutritional (1993) 57: 540-546. This analysis was carried out initially on pullulan. One sample of pullulan was heat treated by autoclaving for 10 minutes at 15 psi and 121° C., to replicate conditions routinely used in the manufacture of foods.

[0074]The following results were obtained:

[0075]

TABLE AIn Vitro digestion of pullulan*% pullulan digestedIngredient0 hr0.5 hr1 hr2.5 hr5 hr15 hr“raw” Pullulan0.024.227.642.456.590.9“cooked Pullulan0.131.531.844.350.586.9*Percent digestible starch, expressed as a percent of ingredient weight, determined by the method of Muir and O'Dea (α-amylase...

example ii

[0076]Based upon the surprising data reported in Example I, the experiment was repeated with additional samples of pullulan of varying molecular weight. For comparative purposes, glucose was tested as well. Data for corn starch as reported in the literature is reported below.

[0077]

TABLE BIn Vitro starch digestion (method described by Muirand O'Dea) of pullulan*% starch digested (DM basis)time of starch digestionIngredient0 hr0.5 hr1 hr2.5 hr5 hr15 hrGlucose110.8101.5100.3100.2102.4103.0Glucose, C101.590.9104.591.496.791.1PF204.913.118.039.348.093.7PF2O, C5.916.620.945.053.695.5Pl201.213.117.341.753.6103.0Pl20, C1.113.519.442.654.496.0*Values are means of duplicate analysis. Percent digestible starch, expressed as a percent of ingredient dry matter, determined by the methods of Muir and O'Dea (α-amylase and amyloglucosidase enzyme system; 1992; a 15 hour in vitro incubation has been shown to correlate with the amount of starch escaping digestion in the small intestine (Muir and O'Dea...

example iii

[0079]This example describes further in-vitro work done with pullulan.

[0080]

TABLE CIn vitro starch digestion (method described by Muirand O'Dea) of pullulan*% starch digested (DM basis)time of starch digestionIngredient0 hr0.5 hr1 hr2.5 hr5 hr15 hrCorn starch0 ± 030.4 ±30.1 ± 0.355.2 ±62.4 ± 1.278.4 ±0.91.80.3Glucose, C9597.8100102108.3108PA, C3.030.833.834.141.470.2PB, C2.327.225.831.55459.8PC, C2.317.119.421.53559.2PF10, C1424.556.461.277.491.8*Historical data from Sigma's raw corn starch. Percent digestible starch, expressed as a percent of ingredient dry matter, determined by the methods of Muir and O'Dea (α-amylase and amyloglucosidase enzyme system; 1992); a 15 hour in vitro incubation has been shown to correlate with the amount of starch escaping digestion in the small intestine (Muir and O'Dea 1993). Time 0 values represent percent free glucose in samples. C = cooked. Values for glucose and pullulan are means of triplicate analysis. PA = pullulan, MW of 6,010. PB = pullulan,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to View More

Abstract

The present invention is directed to the use of pullulan as a slowly digested carbohydrate and to its incorporation into food products, especially beverages and meal replacement products.

Description

[0001]This application is directed to the discovery of a new slowly digested carbohydrate, pullulan, and to its use in the dietary management of diabetics and to food products containing pullulan.BACKGROUND[0002]Primary treatment for glucose intolerance is strict adherence to a diet that minimizes postprandial glucose response, and in many cases, use of medications (insulin or oral hypoglycemic agents).[0003]Before 1921, starvation was the only recognized treatment of diabetes mellitus (DM). Since the discovery of exogenous insulin, diet has been a major focus of therapy. Recommendations for the distribution of calories from carbohydrate and fat have shifted over the last 75 years. Based on the opinions of the time, the best mix to promote metabolic control are listed in Table 1 below.[0004]TABLE 1History of Recommended Caloric Distribution of Persons with DMYearCarbohydrate (%)Protein (%)Fat (%)192120107019504020401971452035198650-6012-20301994*10-20* ^* based on nutritional assess...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A23L1/05A23L1/054A23L1/30A23L1/307A23L1/29A61K31/715A23L2/52A23L29/269A23L33/00A23L33/20A61K31/719A61P3/10C08B37/00
CPCA23L1/0548A23L1/293A61K31/715A23L1/307A23L1/30A23L29/274A23L33/30A23L33/10A23L33/20A61P3/10A23L33/00A23L29/269
Inventor WOLF, BRYAN W.
Owner ABBOTT LAB INC
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com