40 results about "Viral disorder" patented technology

The application provides novel complexes of Cbl-b polypeptides and Cbl-b-associated proteins. The application also provides methods and compositions for treating Cbl-b-associated diseases such as viral disorders.

The present invention relates to compounds of formula 1

or pharmaceutically acceptable salts thereof, wherein

• one of R¹ and R² is methyl, ethyl or isopropyl, and the other is H;
• R³ and R⁴ are each independently H, branched or unbranched C₁-C₆ alkyl, or aryl, and wherein at least one of R³ and R⁴ is other than H;
• R⁵ is a branched or unbranched C₁-C₅ alkyl group or a C₁-C₆ cycloalkyl group, each of which may be optionally substituted with one or more OH groups;
• R⁶, R⁷, R⁸ and R⁹ are each independently H, halogen, NO₂, OH, OMe, CN, NH₂, COOH, CONH₂, or SO₂NH₂. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

The present invention relates to the use of 2-substituted 4-heteroaryl-pyrimidines and related compounds in the treatment of viral disorders.

The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.

The present invention relates to plant extracts and compositions containing such plant extracts useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.

The invention provides an amino-oligosaccharin composition and its preparation method and application. Based on 100% of the total mass of the amino-oligosaccharin composition, it includes the following formula components in mass percentage: hydroxyene adenine 0.0001~ 0.005%, amino oligosaccharin 0.1-1%, organic acid 1-25%, phytonutrient compound 2-15%, solvent 5-30%, surfactant 3-8%, filler 21-89%. The synergistic effect of the amino-oligosaccharin-containing composition of the present invention has a good control effect on plant virus diseases, and has broad-spectrum anti-plant virus properties. Compared with a single agent of amino-oligosaccharin, the control effect on plant virus diseases is improved. 30-100%. The amino oligosaccharin composition has no residue after acting on plants, and is environmentally friendly and safe. The preparation method has simple process, low cost, safety and environmental protection, and is suitable for industrialized production.

Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.

The present invention relates to methods of treating or decreasing the likelihood of developing a disorder associated with immune misregulation, such as, an autoimmune disorder, or viral or virus-associated disorder in a subject including administering to the subject a composition comprising an activator of a CCCH zinc finger-containing PARP, such as, PARP13 or PARP12. The present invention also relates to methods of treating a TRAIL-resistant disorder, such as, TRAIL-resistant cancer including administering to the subject a composition comprising an activator of a CCCH zinc finger-containing PARP, such as, PARP13 or PARP12. The present invention further relates to methods of modulating a CCCH zinc finger-containing PARP-RNA interaction including contacting a CCCH zinc finger-containing PARP protein or a CCCH zinc finger-containing PARP fusion protein with a CCCH zinc finger-containing PARP activator.

The present invention relates to the field of viral disorders, and in particular to viral obesity. Compositions comprising nutraceutical agents are provided for treating viral obesity. Additionally, compositions comprising nutraceutical agents targeting adenoviruses are provided.

The present invention relates to the field of viral disorders, and in particular to the use of natural compounds to inhibit viruses and viral infection. Compositions comprising NGNA are provided for treating or preventing viral infections, such as those causing the common cold.

The present invention relates to compounds of formula (I)

wherein:

R¹ and R² are each independently H, alkyl or haloalkyl;

R³ and R⁴ are each independently H, alkyl, haloalkyl or aryl;

R⁵ is alkyl or cycloalkyl or cycloalkyl-alkyl, each of which may be optionally substituted with one or more OH groups;

R⁶ is selected from cyclopropylamino, cyclopropylmethylamino, cyclobutylamino, cyclobutylmethylamino and

where one of X, Y and Z is N and the remainder are CR⁹;

R⁷, R⁸ and each R⁹ are independently H, alkyl or haloalkyl, wherein at least one of R⁷,

R⁸ and each R⁹ is other than H.

A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (I), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

The present invention relates to chalcone derivatives and compositions containing such derivatives useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.

In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The invention relates to methods and kits for determining and optimizing a personalized treatment regimen for a subject suffering from a pathologic disorder based on calculating the value of M, that indicates the ability of said subject to eliminate said disorder. The invention specifically relates to optimization of interferon treatment of viral disorders.

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisinin derivatives having anti-viral activity.

The invention provides novel polynucleotides, related polypeptides related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic, and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, such as kidney and pancreatic cancer; and inflammatory, immune, and viral disorders.

Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake. Methods of analyzing, imaging and modulating vesicles and cellular vesicles processes are also provided.