108results about "Fluid transfer labware" patented technology

The disposable polymer-structured filtering kit includes a disposable, polymer-structured filtering funnel with a stem having a distal tip. A flow discharge end is formed at the distal tip. Preferably, a polymer fritted filter disc is positioned in the funnel, providing filtering for liquids passing therethrough. The kit preferably also includes a glass vacuum take-off adapter having a port for connecting to a vacuum source for providing negative pressure. The adapter securely and snuggly receives the funnel and maintains position of the distal tip thereof with the flow discharge end below the port, thus preventing contaminants from entering the adapter. A reusable, glass round bottle flask or a disposable vial receives the adapter and the stem of the funnel. The funnel and fritted disc are formed from disposable materials, thus removing the necessity of cleaning them following use. The adapter is reusable, since no contaminants come in contact therewith during filtering.

In order to avoid deposition of evaporating alkali compounds on an inner surface of a hollow glass body during thermal processing to form a glass container from the hollow glass body, an overpressure is provided in the hollow glass body during the thermal processing. Either rinsing the hollow glass body with a gas, such as air, or at least partially closing the glass body at one end so that sufficiently rapid pressure equilibration is avoided, can provide this overpressure. The glass containers made by these methods are especially suited for food or pharmaceuticals because they have a reduced alkali release from their inner surfaces, for example at most about 2.0 mg/l sodium oxide.

Disclosed are methods to aid in a calibration of a vertical orientation of a nozzle tip to a sample container in a processing or testing system. The method includes positioning the nozzle over a calibration target at a home height location (HM), moving the nozzle downward a distance (D) until contact with the calibration target is sensed, positioning the nozzle over the sample rack and moving the nozzle downward until contact with a registration location is sensed, imaging the sample rack and calibration target to determine a height (H) between the registration location and calibration target, and calculating a translation ratio (TR) between the height (H) measured in pixel space and the distance (D) measured in machine space. The translation ratio (TR) may be used to drive the nozzle tip to a predetermined depth. A robot calibration system is disclosed, as are other aspects.

A specimen collection container having a transitional fill-volume indicator is disclosed. The specimen collection container includes an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior. The specimen collection container includes a transitional fill-volume indicator adjacent the sidewall, such that the container defines a first volumetric interior defined by the sidewall between the closed bottom end and the transitional indicator. The specimen collection container also defines a second volumetric interior defined by the sidewall between the closed bottom end and a portion of the sidewall disposed above the transitional indicator. The first volumetric interior is adapted to allow extraction of a specimen therefrom by a first extraction process, and the second volumetric interior is adapted to allow extraction of a specimen therefrom by either the first extraction process or a second extraction process, the second extraction process being different than the first extraction process.

The invention discloses an equivalent continuous dropping liquid-transferring gun. The liquid-transferring gun comprises an outer casing, an outer sleeve and a piston assembly, wherein the piston assembly comprises a piston rod and a piston arranged on the lower side of the piston rod; a spring reset mechanism sleeves the rod body of the piston rod; the liquid-transferring gun further comprises an inner sleeve; the inner sleeve is fixedly arranged in a cavity formed by the outer casing and the outer sleeve; the piston assembly is arranged in the inner sleeve in a penetrating manner; a tooth groove is formed in the outer side wall of the inner sleeve in the axial direction of the inner sleeve; a plurality of one-way ratchets distributed in the axial direction of the inner sleeve in sequence are arranged in the tooth groove; the intervals of the adjacent one-way ratchets are the same; the liquid-transferring gun is also provided with a quantifying buckle; the upper end of the quantifying buckle sleeves a rod body of the piston rod; a tooth hook raised inwards and matched with the one-way ratchets in the tooth groove is arranged at the lower end of the quantifying buckle. The liquid-transferring gun has the advantages that liquid sucked in one time can be divided into a plurality of equivalent liquid drops, the liquid drops are output continuously, the use is convenient and fast, the time is saved, and the efficiency is improved. The gun is simple to maintain, and the production and use costs are relatively low.

A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction. Transfer devices and methods are also provided in which a sterile sample can be transferred from a separation/preparation container (e.g., vacutainer) to a consumer or other container (e.g., dropper) while maintaining sterility of the sample.

The invention discloses a pair of droplet tweezers and a droplet control method. The pair of droplet tweezers comprises two tweezer arms, and two hydrophobic plates which are respectively fixed at thehead ends of the two forceps arms; the two hydrophobic plates are arranged at an angle; and the two hydrophobic plates can relatively translate, and the angle between the two hydrophobic plates is adjustable. According to the droplet tweezers, the direction and the value of capillary force borne by droplets can be changed through structural changes of the hydrophobic non-parallel plates, upward movement and downward movement of droplets can be achieved, and therefore capture/release of droplets is achieved. The method is different from other droplet capturing/releasing methods; the force forcapturing/releasing the droplets comes from the structural characteristics of the non-parallel plates, the droplet tweezers show wide applicability and biocompatibility for hydrophobic properties of different bottom faces, and can become a powerful platform in the aspects of microfluid systems, liquid drop conveying, biological analysis, micro-reaction containers and the like.

The disclosed devices, systems and methods related to the use of a test tube rack to assist with withdrawal of a needle from a container. The rack has a plurality of notches on a top shelf and corresponding openings on a second shelf that allow for the movement of a container stored therein between positions so as to prevent needle sticks and allow for one-handed operation.

The invention discloses a microfluidic syringe filter head and a use method thereof. The filter head uses a microfluidic technology to concentrate and enrich micro-particles or cells, wherein a spirally extending micro-flow channel and a Y-shaped forked flow channel communicated with the micro-flow channel are formed inside the filter head; micro-particles of sample liquid are subjected to dragging force in a flowing direction, and are also subjected to inertial lifting force and Dean dragging force perpendicular to a main flowing direction in the micro-flow channel; under coupling action of the two transverse forces, the micro-particles may be gradually focused to a wall surface on one side close to a spiral center to form a regular arrangement bundle and flow out along a branch inside the Y-shaped forked flow channel so as to collect the concentrated sample liquid. The micro-flow channel and the Y-shaped forked flow channel in the invention are arranged on the same plane so as to effectively reduce a volume occupied by the flow channels and benefit to miniaturization of the filter head; the filter head is simple in use method and suitable for use in the field and low-hardware configuration laboratory environments.

Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor.

The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.

The disposable polymer-structured filtering kit (100) includes a disposable, polymer-structured filtering funnel (110) with a stem (115) having a distal tip (116). Preferably, a polymer fritted filter disc (119) is positioned in the funnel (110), providing filtering for liquids passing therethrough. The kit (100) preferably also includes a glass vacuum take-off adapter (112) having a port (120) for connecting to a vacuum source for providing negative pressure. The adapter (112) securely and snuggly receives the funnel (110) and maintains position of the distal tip (116) thereof with a flow discharge end thereof positioned below the port (120), thus preventing contaminants from entering the adapter (112). A reusable, glass round bottle flask (114) or a disposable vial (214) receives the adapter (112) and the stem (115) of the funnel (110). The funnel (110) and fritted disc (119) are formed from disposable materials, thus removing the necessity of cleaning them in following use. The glass vacuum take-off adapter is not soiled after use, and can be used repeatedly without cleaning.

A fluid transfer device includes a syringe barrel having a chamber, a first plunger slidably movable inside the chamber, and a second plunger slidably movable inside the chamber. The distal end portion of the first plunger is engageable with the proximal end portion of the second plunger such that when the distal end portion of the first plunger and the proximal end portion of the second plunger are engaged, the second plunger is movable by the first plunger. A check valve may be incorporated into the distal end portion of the second plunger to allow a fluid to pass therethrough in a direction towards the proximal end portion of the second plunger and prevent a fluid to pass therethrough in a reverse direction. A fluid transfer assembly and a sampling method are also described.

The invention relates to the field of medical appliances, particularly a collecting device for collecting the body fluid. The fluid extractor for closed body fluid retention devices comprises an annular side wall and a channel assembly, wherein the annular side wall forms a channel; the channel assembly is arranged in the channel and positioned on the lower part of the channel; the channel assembly and annular side wall form a split fit; the channel assembly is provided with a through hole; the upper part of the channel is used for collecting the fluid; and the lower part of the channel is matched and connected with the channel assembly. The fluid extractor is capable of lowering the cost and enhancing the production efficiency; and when the excess fluid is poured out of the fluid extractor, the fluid in the test tube can be prevented from being poured out from the diversion channel or exhaust channel.

An apparatus and method are provided for rapid and precise manipulation and transfer of tiny liquid droplets. by dynamically introducing microstructures with relatively high surface energy to a non-wettable surface, which surface has in-situ switchable adhesion to liquid droplets. By penetrating microstructures on the background surface, the chemical property of the surface is locally modified. Capillary bridges will form between microstructures and liquid droplets which lead to high adhesive forces. When the microstructures are retracted, the capillary bridges either pinch-off or recede, which drastically reduces the adhesion. With proper chemical modification, the surface can either manipulate a liquid droplet in air or in an immiscible carrier liquid. Tiny droplets with volumes down to nanoliter scale can be prepared and dispensed by using the surface.

The invention provides for the steam of a solvent to reach the space of an extractor following two possible routes thus exposing the sample to a continuous flow of fresh solvent, causing the extractant fluid to be fed through the sample by its upper and lower ends, which increases the extraction radius and as result a high percentage of the extracted component is obtained, reducing substantially the amount of solvent used and therefore reducing the processing time.

Disclosed herein are analytical aids having a surface coated at least partially with a hydrophilic coating, where the hydrophilic coating includes nanoparticles with silica structure and an average particle size in a range from about 1 nm to about 500 nm. Also disclosed are methods of producing the analytical aids, as well as using the analytical aids in, for example, a sampling device containing the at least partially coated analytical aid.

The present invention relates to the design and use of a multipurpose reactor that may be adapted to accommodate a wide variety of solid phase and liquid phase reaction chemistries.

Digital microfluidics system manipulates samples in liquid droplets within a gap of at least one disposable cartridge. It is also provides additional space for collecting and/or storing waste fluids in this digital microfluidics system. It includes at least one waste hollow which is fluidly connected with a gap of a disposable cartridge that includes a bottom layer with a first hydrophobic surface and a top layer with a second hydrophobic surface. The waste hollow is located next to at least one individual waste electrode that is positioned next to at least one individual electrode of an electrode array. Each individual waste electrode is operatively connected to a central control unit and covers in each case a waste electrode area.