66results about "Fluid transfer labware" patented technology

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

An auto-pipetting apparatus includes a dispensing head with at least one pipetting tip mandrel (200) having an elongated stud body (300) with an insertion end. The at least one pipetting tip mandrel mates with a pipetting tip (399). A first adjustable seal (310A), disposed on the elongated stud body, and a second adjustable seal (310B), disposed on the elongated stud body, seal the pipetting tip mated to the at least one pipetting tip mandrel. The first adjustable seal defines a snub surface. The snub surface effects a substantially continuous circumferential contact seal with radially impinging contact between the pipetting tip and the at least one pipetting tip mandrel. The second adjustable seal is adjustable between a disengaged position and an engaged position and effects a releasable grip and another substantially continuous circumferential contact seal between the pipetting tip and the at least one pipetting tip mandrel around the pipetting tip.

The present invention relates to an apparatus (1) and method (2) for automatically preparing liquid-based cytology (LBC) slides (107) by means of filtration comprising of at least one substrate (101) for holding a vial (103) containing specimen, a filter (105) and a slide (107) wherein said substrate (101) is located at a first station (FS); at least one working station (WS) comprises of a working platform (109) connected to said first station (FS) wherein said first station (FS) includes a vertical rotary conveyor system (121) which is flexible, user friendly and capable of providing uniformity of the cell distribution in the homogenous thin-layer LBC slides (107) as well as increase system throughput.

A method for repositioning and transferring N distinct biological samples from N distinct first locations arranged in an irregular pattern to M distinct second locations arranged in a regular pattern on a transfer device, the transfer device comprising at least M adhesive transfer regions, the at least M adhesive transfer regions being formed from at least one flexible sheet material, and N≧2 and N≧M.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

A method of producing a sample collection apparatus (40), including steps of: attaching a holding member (80) to a support (70) of a nozzle unit (60) such that, in slits (72) provided with N edges (N ≥ 3), a collection range (11B) w of a sample tube (11) is included within a range from a lower-limit position (94) at a distance w / 2 from a 1st edge (73a) toward an initial-position (90), to an upper-limit position (96) at a distance w / 2 from an Nth edge away from the initial position (90); loading the sample tube (11) on the holding member (80); counting the number of pulses with which a pulse motor (50) is driven to move a nozzle (61) to the center of the collection range (11B); identifying the signal corresponding to the last edge recognized by a photo-interrupter (62) before the nozzle (61) reaches the center of the collection range (11B); and storing the number of pulses and the signal corresponding to the last edge in a storage device (150).

The filter suction holder (310) can be inserted into a reaction tube for extracting nucleic acid from a sample, together with a filter for collecting the sample by filtering the sample including the sample having nucleic acid, the filter suction holder (310) having a housing part (311). The accommodating part (311) is provided with an inner wall surface (312) which is in close contact with the surface of the filter and adsorbs the filter.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

A method of rearranging and transferring N individual biological samples from N individual first locations arranged in an irregular pattern to M individual second locations arranged in a regular pattern on a transfer apparatus comprising at least M adhesive transfer regions, wherein the at least M adhesion transfer regions are formed from at least one sheet of flexible sheet material, and wherein N > = 2 and N > = M.

The present invention relates to a flow distributor for a parallelized microfluidic chip system, adapted for the individual feeding of a large number of microfluidic channels. In particular, the invention proposes a distributor comprising at least one radial flow distribution channel, said channel having a central opening leading into peripheral openings distributed circularly around an axial center of said distributor, characterized in that: - the distributor comprises a support in the form of a regular cylinder, preferably circular, in which said at least one radial distribution channel is integrated, and such that - the peripheral openings are distributed on vertical walls of said support to convey a flow into or out of said distributor along a horizontal flow plane.

An auto-pipetting apparatus includes a dispensing head with at least one pipetting tip mandrel having an elongated stud body with an insertion end. The at least one pipetting tip mandrel mates with a pipetting tip. A first adjustable seal, disposed on the elongated stud body, and a second adjustable seal, disposed on the elongated stud body, seal the pipetting tip mated to the at least one pipetting tip mandrel. The first adjustable seal defines a snub surface. The snub surface effects a substantially continuous circumferential contact seal with radially impinging contact between the pipetting tip and the at least one pipetting tip mandrel. The second adjustable seal is adjustable between a disengaged position and an engaged position and effects a releasable grip and another substantially continuous circumferential contact seal between the pipetting tip and the at least one pipetting tip mandrel around the pipetting tip.

To ejecting droplets from a plurality of reservoirs. As the reservoirs and at least one acoustic ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoirs. Based on received echoes corresponding to the one or more interrogation pulses, the system determines an order of ejection.

A method and device for purifying fluids in a container and providing a system for the cleaning of a container in automated analyser systems, comprising a pump which is connected to a single injection nozzle, wherein the single injection nozzle is configured to provide an oscillating fluidic jet, as well as a method for the cleaning of a container in automated analyser systems, comprising the following steps of arranging a container in a mount below a single oscillation nozzle; providing a cleaning fluid to a pump, which is connected to a controller and the oscillation nozzle; aligning the oscillating fluidic jet to a surface of the container which is to be cleaned; applying a cleaning fluid through the pump to the oscillation nozzle; and cleaning a surface of the container with the cleaning fluid.

The invention relates to a device suitable for being plugged directly into a microfluidic chip which has at least one opening, the device comprising a body which contains a plurality of independent fluid tanks, wherein each fluid tank has an inlet configured for receiving a fluid and an outlet, forming an open end of the fluid tank and being configured to deliver the corresponding fluid directly into at least one opening of the microfluidic chip, characterized in that each outlet has a smaller opening compared with its corresponding inlet and is configured to be in a sealed fluidic communication with at least one opening of the microfluidic chip.

Containers for small liquid volumes have at least one inlet chamber, at least one outlet chamber, an open top end and a bottom end which includes at least one access region. At least one inlet chamber is capable of accommodating a swab stick and is provided with at least one open top end and is connectable to at least a first free end of a flowpath via the at least one access region. The at least one outlet chamber has at least one open top end and is connectable to at least another free end of the flowpath via the at least one access region. A kit, an interface for fluid handling, and a method for analyzing a sample liquid are also provided.

A method for penetrating a pierceable cap (11) on a vessel (21). The pierceable cap (11) prevents escape of sample specimens from the vessel (21) before transfer with a transfer device (43). The pierceable cap (11) may fit over a vessel (21). An access port in the shell of the pierceable cap (11) may allow passage of a transfer device (43) through the pierceable cap (11). At least one frangible layer (215, 216) may be configured with cross slits (506) in a particular cross slit geometry. The cross slits (506) may contain an openable portion (644) or be covered by a thin membrane (645). The shell (610) and frangible layer(s) (215, 216) may be integrated into a one piece cap (601), or be separate components (634). The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device (43) to the cross slits (506). The flat surfaces are supported by rib structures (620, 621) that extend radially inward and downward into the vessel (21).

The present invention relates to a flow distributor for a parallelized microfluidic chip system, adapted for the individual feeding of a large number of microfluidic channels. In particular, the invention proposes a distributor comprising at least one radial flow distribution channel, said channel having a central opening leading into peripheral openings distributed circularly around an axial center of said distributor, characterized in that: - the distributor comprises a support in the form of a regular cylinder, preferably circular, in which said at least one radial distribution channel is integrated, and such that - the peripheral openings are distributed on vertical walls of said support to convey a flow into or out of said distributor along a horizontal flow plane.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

The present invention relates to a flow distributor for a parallelised microfluidic chip system, which is suitable for individually supplying a large number of the microfluidic channels. In particular, the invention proposes a distributor including at least one radial flow distribution pipe, the pipe having a central opening leading into peripheral openings distributed circularly around a radius about an axial centre of the distributor, characterised in that: - the distributor includes a support in the form of a regular cylinder, preferably of circular shape, into which the at least one radial distribution pipe is integrated, and such that - the peripheral openings are distributed on vertical walls of the support in order to convey a flow at the inlet or at the outlet of the distributor according to a horizontal flow plane.

Diagnostic assay devices for detecting the presence of an analyte in a sample solution may comprise a microreactor configured to form a sample solution containing the analyte, flow the sample solution therethrough in a first direction to form an analyte-capture molecule complex, and transfer the sample solution to an absorbent strip pad configured to flow therethrough, in a second direction crossing the first direction, the sample solution including the analyte-capture molecule complex and indicate a presence of the analyte-capture molecule complex. The diagnostic devices may be used, for example, to identify the presence of SARS-Cov2, RSV, influenza A, influenza B or other pathogens in samples from patients.

A method of producing a sample collection apparatus, including steps of: attaching a holding member to a support of a nozzle unit such that, in slits provided with N edges (N≥3), a collection range w of a sample tube is included within a range from a lower-limit position at a distance w / 2 from a 1st edge toward an initial-position, to an upper-limit position at a distance w / 2 from an Nth edge away from the initial position; loading the sample tube on the holding member; counting the number of pulses with which a pulse motor is driven to move a nozzle to the center of the collection range; identifying the signal corresponding to the last edge recognized by a photo-interrupter before the nozzle reaches the center of the collection range; and storing the number of pulses and the signal corresponding to the last edge in a storage device.

The invention discloses a gas injection device, a gas-liquid two-phase flow experimental measurement system and a gas-liquid two-phase flow experimental measurement method. The air storage box is arranged on the bracket; the air inlet pipe is arranged on the bottom side of the air storage box and one end communicates with the interior of the air storage box; and the multiple anti-backflow nozzles are distributed on the top side of the gas storage box in an array mode, and one end of each anti-backflow nozzle communicates with the interior of the gas storage box. According to the gas injection device, when the gas injection device is applied to a gas-liquid two-phase flow experiment device, a plurality of bubble flows generated by the anti-backflow gas nozzles can form mutually disturbed convection fields, bubbles are promoted to be uniformly mixed in liquid metal, and when the bubbles of the adjacent anti-backflow gas nozzles rise, the surrounding liquid metal can be driven to form local circulation, so that the gas injection device can be used for gas-liquid two-phase flow experiment. After the circulation is overlapped, the bubbles can be pushed to a farther area, so that the bubbles can be uniformly distributed in the experimental device, and researchers can accurately measure related experimental parameters of the migration characteristics of the bubbles in the liquid metal in the experimental device.

A fluidic cartridge kit, including: a fluidic cartridge having an analysis portion and a sample reservoir sealed with a removable shipping closure to contain contents of the sample reservoir during transport; and a dispensing cap; wherein the dispensing cap includes: a closure and dispensing component configured to engage the dispensing cap to the fluidic cartridge and close an opening of the sample reservoir of the fluidic cartridge following removal of the shipping closure from the sample reservoir; a compressible sealing component configured to form a seal between the closure and dispensing component and the sample reservoir and thereby seal the sample reservoir; and a sample release component coupled to the closure and dispensing component and configured to make an opening in a wall of the sealed sample reservoir; and wherein the closure and dispensing component is operable to engage the fluidic cartridge, close the sample reservoir, and compress the compressible sealing component therebetween to seal the sample reservoir, wherein the sample reservoir is partially filled with a sample fluid; wherein the closure and dispensing component is further operable to compress the compressible sealing component and thereby pressurise the sealed sample reservoir and to cause the sample release component to make the opening in the wall of the pressurised sample reservoir; and wherein the closure and dispensing component, the compressible sealing component and the sample release component are configured such that the pressurised sample reservoir is pressurised to a predetermined pressure range that causes at least a portion of the sample fluid to be dispensed through the opening in the pressurised sample reservoir into the analysis portion of the fluidic cartridge.

Disclosed is a tester stand including: a body having a predetermined height, and a chamber task area and a device task area each formed in a groove shape engraved in an upper surface of the body; a chamber seating portion formed by protruding from a bottom surface of the chamber task area and in which the chamber is placed; a device seating portion having a device insertion groove formed in a bottom surface of the device task area so that a part of the tester is seated therein, and having a downward fastening insertion groove on the bottom surface of the device insertion groove; and a height adjustment portion fitted into the fastening insertion groove so that a support plate is positioned on the bottom surface of the device insertion groove.

The present disclosure relates to a nozzle for a sample processor, a carrier of the nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a removable manner. An orifice is provided in the body and configured to inject a sample from the injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and sample processor according to the present disclosure include the nozzle described above and a carrier.

The invention relates to a device suitable for being plugged directly into a microfluidic chip which has at least one opening, the device comprising a body which contains a plurality of independent fluid tanks, wherein each fluid tank has an inlet configured for receiving a fluid and an outlet, forming an open end of the fluid tank and being configured to deliver the corresponding fluid directly into at least one opening of the microfluidic chip, characterized in that each outlet has a smaller opening compared with its corresponding inlet and is configured to be in a sealed fluidic communication with at least one opening of the microfluidic chip.

A filter suction holder is insertable into a reaction tube together with a filter. The filter is configured to capture a specimen having nucleic acid by filtering a sample containing the specimen. The reaction tube is to be used for extracting the nucleic acid from the specimen. The filter suction holder includes a container for containing the filter. The container has an inner wall surface configured to stick to a surface of the filter and cause the filter to be absorbed.