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Sodium hyaluronate anti-adhesion film, and its prepn. method

A sodium hyaluronate and anti-adhesion technology, which is applied to the anti-adhesion film in the abdominal cavity for pain relief. The preparation of the film, sodium carboxymethyl cellulose, can solve the problems that no one has developed an anti-adhesion film of sodium hyaluronate

Inactive Publication Date: 2007-08-29
上海建华精细生物制品有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, anti-adhesion films containing sodium hyaluronate and pamodol have been developed abroad for clinical phase III trials, but no one has developed a sodium hyaluronate anti-adhesion film containing carrageenan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Dissolve 1.0 g of sodium hyaluronate (molecular weight: 1.57 million), 0.1 g of pamodol, 1.0 g of carboxymethyl cellulose, and 1.0 g of carrageenan in 100 ml of PBS buffer. Preparation method: Dissolve 1.0g sodium hyaluronate and 0.033g pamodizone in 33.3ml PBS buffer to prepare solution 1; dissolve 1.0g carboxymethyl cellulose and 0.033g pamodizone in 33.3ml PBS buffer , heated and dissolved in a water bath (40°C) while stirring, and prepared into solution 2; then dissolved 1.0g of carrageenan and 0.033g of acetidine in 33.3ml of PBS buffer, heated and dissolved in a water bath (40°C), and carried out at the same time Stir to prepare solution 3; mix and stir solutions 1, 2, and 3 for 5 hours, and form a gel after being fully uniform, pour it into a film forming device, put it in a refrigerator and freeze-dry it at -10°C for 24 hours, and wait for the film to form Finally, use a spatula to gently lift the film to obtain a film.

Embodiment 2

[0034] Sodium hyaluronate (molecular weight: 2.02 million) 1.2g, pamodol 0.12g, carboxymethylcellulose 1.2g, and carrageenan 1.0g were dissolved in 120ml of PBS buffer. Preparation method: Dissolve 1.2g of sodium hyaluronate and 0.04g of pamodizone in 60ml of PBS buffer to prepare solution 1; Heat the pot to dissolve (60°C) while stirring to prepare Solution 2; dissolve 1.0g of carrageenan and 0.04g of acetidine in 30ml of PBS buffer solution, heat to dissolve in a water bath (60°C) while stirring to prepare Solution 3: Mix and stir the solutions 1, 2, and 3 for 5 hours, and form a gel after being fully uniform. Gently peel off the film to obtain a film.

Embodiment 3

[0036] Sodium hyaluronate 1.4g (molecular weight 1.15 million), pamodol 0.10g, carboxymethylcellulose 1.4g, and carrageenan 1.4g were dissolved in 100ml of PBS buffer. Preparation method: Dissolve 1.4g of sodium hyaluronate and 0.04g of pamodizone in 40ml of PBS buffer to prepare solution 1; dissolve 1.4g of carboxymethyl cellulose and 0.03g of pamodizone in 30ml of PBS buffer and place in a water bath Heat the pot to dissolve (40°C) while stirring to prepare Solution 2; dissolve 1.4g of carrageenan and 0.03g of acetidine in 30ml of PBS buffer solution, heat to dissolve in a water bath (40°C) while stirring to prepare Solution 3: Mix and stir the solutions 1, 2, and 3 for 4.5 hours, and form a gel after being fully uniform. Gently peel off the film to obtain a film.

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Abstract

An anti-adhesive sodium hyaluronated film with anti inflammatory, antalgic and anti-adhesive functions is prepared from sodium hyaluronated, valoron, carragheenin and carboxymethyl cellulose sodium through respectively preparing three kinds of solution, mixing, pouring in filming device, freeze drying and forming film.

Description

technical field [0001] The present invention relates to an intraperitoneal anti-adhesion film, and more specifically relates to an intraperitoneal anti-adhesion film with sodium hyaluronate, tamonadine, and carrageenan as main components, supplemented with sodium carboxymethylcellulose, and has anti-inflammatory and analgesic effects. Adhesive film. [0002] The invention also relates to a method for preparing the film. Background technique [0003] In the field of laparotomy, especially in the field of digestive tract surgery, intestinal adhesion is very easy to occur. With the development of science and technology and the improvement of medical level, this tendency of adhesion is gradually reduced, but it is still difficult to prevent and solve it. Adhesion is a very difficult problem in the field of gynecological surgery. In obstetrics and gynecology surgery, postoperative adhesions often cause occlusion of the fallopian tubes and cause infertility. At the same time, int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/50A61K31/728A61K9/70A61P41/00
Inventor 毕莹何文龙
Owner 上海建华精细生物制品有限公司
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