In vitro biologic artificial liver supporting device

Abstract

An in vitro type biological artificial liver support device, characterizing in comprising culture fluid circular flowing mechanism and patients plasma circular flowing mechanism. The culture fluid circular flow mechanism is made up of a culture fluid peristaltic pump, a culture fluid bottle, a oxygen dispersion pipe and a culture fluid transporting pipe, among which the culture fluid transporting pipe is connected with a culture fluid channel which is formed from hollow fiber and being passed through biological reactor outer cavity. Patients plasma circular flow mechanism comprises a plasma peristaltic pump, a plasma bag, a plasma transporting pipe and a plasma channel, among which the plasma transporting pipe are connected with a plasma channel making by hollow fiber and being passed through biological reactor outer cavity. It can remain more beneficial substance in patients blood, only small quantity of plasma of normal human is needed, and can conduct specific detoxification and biological function by the high active liver cell in the biological reactor for a long time.

Description

(1) Technical field [0001] The invention relates to a medical device, in particular to a liver support device for an extracorporeal bioartificial liver mainly used in the treatment of clinical liver failure. (2) Technical background [0002] At present, there are two types of artificial liver support devices commonly used: plasma replacement artificial liver support device and hepatic cell culture biological artificial liver support device. [0003] Plasma exchange type artificial liver support device is mainly composed of separator, blood pump, Memphis tube and liquid tube. It uses fresh frozen plasma from normal people to replace the plasma containing toxic substances in the patient's body. When in use, both the input port and the output port are connected with the patient's blood vessels by puncture, and the plasma in the patient's blood is separated through a separator, and the plasma containing toxic substances but also beneficial substances to the human body is discard...

AI Technical Summary

Problems solved by technology

The disadvantages of this therapy are: it needs to consume a large amount of fresh frozen plasma, generally 3000-4000ml each time; it is prone to blood transmission of human immunodeficiency virus (HIV), hepatitis virus, etc.; a few patients may have allergic reactions; The beneficial substances in the patient's body, including the liver regeneration factor needed for the recovery of the patient's condition

However, in actual treatment, it is difficult to accurately evaluate the liver-specific detoxification function, biosynthesis and transformation function, and liver regeneration promotion function of the bioartificial liver, so it is difficult to prepare liver cells and bioreactors according to the patient's condition to ensure liver function. support effect

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