Two kinds of oral drip pills for treating tracheitis and its preparation method

A technology of chronic bronchitis and sophora flavescens, applied in the direction of medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc., can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, the first-pass bioavailability of the liver and intestines, and the overall health level and other issues, to achieve the effects that are conducive to labor protection and environmental protection, improve bioavailability, and ensure the quality of drugs

Inactive Publication Date: 2007-11-14
北京博智绿洲医药科技有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] Now with several groups of specific examples, the preparation method of the Tanchuan dripping pills of the present invention will be further described.

[0030] [Group 1: Trials with a single substrate]

[0031] 1. Raw materials: the extract containing the active pharmaceutical ingredients of Sophora flavescens prepared in accordance with [Appendix];

[0032] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0033] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0034] 4. According to the process given in [Preparation Method] 4-7, different specifications of Tanchuan Dropping Pills can be obtained.

[0035] [test results]

[0036] Experiment 1: In order to observe the difference in quality of the Tanchu...

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Abstract

Two Chinese medicines 'Tanjing dripping pill' and 'Tanchuan dripping pill' for treating cough with sputum, asthma, chronic bronchitis, etc is prepared from phytolacca root, flavescent sophora root and medicinal carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition which has the functions of relieving cough, eliminating phlegm and relieving asthma, and is used for treating chronic bronchitis, in particular to an oral preparation of the pharmaceutical composition prepared from traditional Chinese medicine Sophora flavescens dry extract. Background technique [0002] Tanchuan Tablets published in the National Drug Standard WS-11522 (ZD-1522)-2002 is an oral tablet for the treatment of chronic bronchitis with the functions of relieving cough, eliminating phlegm and relieving asthma. It is a commonly used drug for clinical and family treatment of the above diseases. [0003] Here is a brief description of this oral formulation: [0004] Drug name: Tanchuan Tablets [0005] Prescription: Sophora flavescens dry extract 75g, starch 25g [0006] Preparation method: Take the dry extract of Sophora flavescens, crush it into fine powder, add starch, mix well, make gra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/489A61P11/14A61P11/10A61P11/06A61K125/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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