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Magnetic nano-balls carried with cisplatin and its prepn. method

A magnetic nanosphere, nanotechnology, applied in the nano field, can solve the problems of lack of targeting, inability to play an anti-cancer effect, and drug resistance.

Inactive Publication Date: 2007-12-19
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cisplatin-based chemotherapy still has many problems: ① Cisplatin has a low molecular weight and is transported too quickly in the blood circulation, so it cannot exert its anti-cancer effect well; ② Intravenous administration, systemic chemotherapy, has large toxic and side effects; ③ After long-term chemotherapy, it is easy to lead to drug resistance in the body
Liposomes, polymers, polysaccharides, etc. are currently being studied. These carriers can control the release of drugs, but they do not have targeting

Method used

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  • Magnetic nano-balls carried with cisplatin and its prepn. method
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  • Magnetic nano-balls carried with cisplatin and its prepn. method

Examples

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Effect test

Embodiment 1

[0032] ① Take 9.6g FeCl 3 ·6H 2 O, formulated as FeCl with a mass concentration of 60% 3 solution, weighing 5g FeSO 1 ·7H 2 O, formulated as FeSO with a mass concentration of 20% 1solution, the two solutions are mixed to form an iron salt mixed solution (ferrous sulfate: the molar ratio of ferric chloride=1:2). The sodium alginate that 20g weight average molecular weight is 20,000 is dissolved in 100ml concentration and is made into sodium alginate ammonia water mixed solution (ammonia water: the mol ratio of ferric chloride is 40: 1, and sodium alginate is to The mass ratio of ferric oxide is 5:1). The iron salt mixed solution and the sodium alginate ammonia mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. ②After the reaction, use a centrifuge to centrifuge the prepared water-based ferroferric oxide magnetic liquid to remove the precipitated large particles, ensure t...

Embodiment 2

[0034] ① Take 9.6g FeCl 3 ·6H 2 O, formulated as FeCl with a mass concentration of 30% 3 solution, weighing 6g FeSO 4 ·7H 2 O, formulated as FeSO with a mass concentration of 15% 4 solution, the two solutions are mixed to form an iron salt mixed solution (ferrous sulfate: the molar ratio of ferric chloride=1.2:2). It is 20,000 potassium alginate that 16g weight average molecular weight is dissolved in 80ml concentration and be made into potassium alginate ammonia water mixed solution (ammonia water: the mol ratio of ferric chloride is 32: 1, and potassium alginate is to The mass ratio of ferric oxide is 4:1). The iron salt mixed solution and the potassium alginate ammonia mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. Step ② and step ③ are the same as in Example 1 to obtain potassium alginate-modified nano ferric oxide particles (the mass ratio of potassium alginate...

Embodiment 3

[0036] ① Take 9.6g FeCl 3 ·6H 2 O, formulated as FeCl with a mass concentration of 45% 3 solution, weighing 7g FeSO 4 ·7H 2 O, formulated as FeSO with a mass concentration of 20% 4 solution, the two solutions are mixed to form an iron salt mixed solution (ferrous sulfate: the molar ratio of ferric chloride=1.4:2). 16g weight average molecular weight is that 20,000 alginic acid is dissolved in 100ml concentration and is made into alginic acid ammonia water mixed solution (ammonia water: the mol ratio of iron trichloride is 40: 1, and alginic acid is to trioxide tetroxide The mass ratio of iron is 4:1). The iron salt mixed solution and the alginic acid ammonium aqueous mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. Step ② and step ③ are the same as in Example 1 to obtain alginic acid-modified nano ferric oxide particles (the mass ratio of alginic acid to nano ferric o...

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Abstract

A magnetic nanoball carrying cisplatin is disclosed, which can be used as the medicine carrier to provide magnetic targetability. Its preparing process includes such steps as preparing the carboxypolyose modified Fe3O4 nanopartieles by chemical codeposition method under existence of carboxypolyose, and coordination between the free carboxy in carboxypolyose on the surface of Fe3O4 nanoparticle and Pt atoms for coupling the cisplatin with said nanoparticle. It can be used for the controlled slow-release medicine applying system.

Description

technical field [0001] The invention relates to the field of nanotechnology, in particular to a cisplatin-loaded nanosphere and a preparation method thereof. Background technique [0002] Cisplatin (Cis-dichlorodiamine platinum) is the most commonly used cell cycle non-specific high-efficiency anti-tumor drug in clinic. It can be used to treat ovarian cancer, testicular cancer, bladder cancer, gastrointestinal tumors, especially head and neck tumors. Its anticancer The main mechanism is to inhibit DNA replication by forming cross-links between DNA or between DNA and proteins. However, there are still many problems in cisplatin-based chemotherapy: ① Cisplatin has a low molecular weight and is transported too fast in the blood circulation, so it cannot exert its anti-cancer effect well; ② Intravenous administration, systemic chemotherapy, has large toxic and side effects; ③ After long-term chemotherapy, it is easy to lead to drug resistance in the body. In order to increase ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/36A61K47/02A61K31/282A61P35/00
Inventor 谢民强徐雪青沈辉李仲汉陈帅君许家瑞
Owner SUN YAT SEN UNIV