Compound injection from Chunxiongqin and Sanchi general saponin and its preparation

A technology of Panax notoginseng saponins and injection preparations, which is applied in the field of compound injections and its preparation, which can solve the problems of large dosage of saponins and easy occurrence of saponin hemolysis, etc., and achieve the effects of less toxic and side effects, good clinical treatment effects, and abundant resources

Inactive Publication Date: 2008-07-09
JIANGSU CAREFREE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the intravenous administration of total saponins of Panax notoginseng (Xuesaitong injection and Xueshuantong injection) is widely used. Because of the administration of pure Panax notoginseng saponins, the dosage of saponins is relatively large, and adverse reactions such as saponin hemolysis are also prone to clinically.

Method used

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  • Compound injection from Chunxiongqin and Sanchi general saponin and its preparation
  • Compound injection from Chunxiongqin and Sanchi general saponin and its preparation
  • Compound injection from Chunxiongqin and Sanchi general saponin and its preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Embodiment 1: the preparation of injection

[0050] Take Ligustrazine 20g, grind finely, add 1000ml water for injection to dissolve completely. Get the raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 Total amount 50-90%) 200g add 2-4L water for injection to dissolve. Slowly add the aqueous solution of ligustrazine to the aqueous solution of Panax notoginseng saponins, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 10,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.

Embodiment 2

[0051] Embodiment 2: the preparation of transfusion

[0052] Take Ligustrazine 13g, grind finely, add 2400ml water for injection and stir to dissolve completely. Get the raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 Total amount 50-90%) 200g add 2-4L water for injection to dissolve. Slowly add the aqueous solution of Ligustrazine to the aqueous solution of Panax notoginseng saponins, stir while adding, and add to an isotonic pressure regulator, the isotonic agent is at least one of mannitol, sodium chloride or glucose, And dilute to 100L or 250L with water for injection, stir well. The medicinal solution is ultrafiltered by an ultrafiltration membrane with a pore size of 30,000 molecular weight, supplemented with an appropriate amount of water for injection, subpackaged into 100ml or 250ml / bottle, filled with caps, and sterilized to obtain an infusion solution.

Embodiment 3

[0053] Embodiment 3: the preparation of freeze-dried powder injection

[0054] Take Ligustrazine 20g, grind finely, add 40ml water for injection to dissolve, set aside. Get the raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 50-90% of the total amount) 200g, add appropriate amount of water for injection to dissolve. Slowly add the ligustrazine solution into the aqueous solution of Panax notoginseng saponins, stir until clear while adding, dilute to 50L with water for injection, and dissolve. The medicinal solution is ultrafiltered by an ultrafiltration membrane with a flux of 10,000 molecular weight, divided into 5 ml bottles, freeze-dried, capped, and labeled to obtain powder injections, with a total of 10,000 bottles.

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PUM

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Abstract

A Chinese medicine in the form of injection for treating cardiovascular and cerebrovascular diseases such as cerebral infaretion, cerebral ischemia, coronary heart disease, angina pectoris and myocardial infarction is prepared from chuanxiongzine and arasaponin proportionally.

Description

technical field [0001] The invention relates to a compound injection composed of traditional Chinese medicine raw materials in a certain proportion and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among urban population, tumors accounted for the first place, and cerebrovascular diseases accounted for the second place. Disease takes second place. Ischemic cerebrovascular disease accounts for about 70% of all cerebrovascular diseases....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K36/236A61K31/704A61K31/4965A61K9/14A61P9/00
Inventor 秦引林何龙其周续增
Owner JIANGSU CAREFREE PHARM CO LTD
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