Effervescent tablet containing cefixime and its preparing method

A technology for cefixime and effervescent tablets, which is applied in the field of effervescent tablets containing cefixime and its preparation, can solve the problems of difficulty in uniform dispersion and difficulty, and achieves fast onset speed, high blood drug concentration, and easy storage and storage. carry effect
CN100417383CInactive Publication Date: 2008-09-10CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2008-09-10
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention relates to an effervescent tablet containing cefixime and its preparation method. It contains 25-400 mg of cefixime and pharmaceutically-acceptable acid-dbase pair. Besides, the pharmaceutically-acceptable filling agent, adhesive, disintegrating agent, lubricating agent, sweetener and corrective also can be added according to the requirements.
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Description

Technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet containing cefixime and a preparation method. Background technique

[0002] Cefixime is a third-generation oral cephalosporin, which is clinically suitable for acute attacks of pharyngitis, tonsillitis, acute bronchitis and chronic bronchitis caused by sensitive bacteria, otitis media, urinary tract infection, simple gonorrhea (cervicitis or urethritis) ) And other treatments.

[0003] According to the American Physician’s Desk Reference (PDR57) version, after oral administration of cefixime tablets and dry suspension, the absolute bioavailability is 40%-50%, and the peak plasma concentration time after oral administration is 2-6 hours. The bioavailability of cefixime solid preparations is low, and the onset of action is slow.

[0004] The current clinical application dosage forms of cefixime include tablets, capsules, dry suspensions, granul...

Claims

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