Use of steroidal compound and total steroidal extract for preparing anti-depression drug

A compound, total sterol technology, applied in the field of natural medicinal chemistry, can solve problems affecting the quality of life of patients, adverse reactions, toxic and side effects, etc.

Inactive Publication Date: 2008-12-10
BIOPHARML TECH SHANGHAI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The chemically synthesized drugs currently used to treat depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, but all of them have different degrees of adverse reactions, and serious side effects will appear after long-term use , greatly affecting the quality of life of patients

Method used

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  • Use of steroidal compound and total steroidal extract for preparing anti-depression drug
  • Use of steroidal compound and total steroidal extract for preparing anti-depression drug
  • Use of steroidal compound and total steroidal extract for preparing anti-depression drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Extraction and separation of sterol compound acylated sitosteryl glucoside (Acylated sitosteryl glucoside).

[0068] Take 1 kg of dried bulbs (leaves) of Liliaceae plant Lilium, extract with 80% ethanol under reflux, concentrate the extract to obtain ethanol extract, suspend the extract in water, extract with petroleum ether, and concentrate to obtain petroleum ether extract. The ether extract was subjected to silica gel column chromatography, gradient elution, wherein 15-16 # Some of them were subjected to silica gel column chromatography to obtain 6'-O-linoleoyl 3-O-glucosyl-β-sitosterol (see Table 1 for NMR data).

Embodiment 2

[0069] Embodiment 2: Extraction and separation of sterol compound β-sitosterol glucoside

[0070] Take 1 kg of dried bulbs (leaves) of Liliaceae plant Lilium, extract with 80% ethanol under reflux, concentrate the extract to obtain ethanol extract, suspend the extract in water, extract with ethyl acetate, and concentrate to obtain ethyl acetate extract , the ethyl acetate extract was subjected to silica gel column chromatography, chloroform-methanol gradient elution, and then SephadexLH20 gel column chromatography to obtain β-sitosterol-3-O-glucoside (see Table 1 for NMR data).

Embodiment 3

[0071] Example 3: Extraction and separation of sterol compound β-sitosterol

[0072] Take 1 kg of dried bulbs (leaves) of Liliaceae plant Lilium, extract with 80% ethanol under reflux, concentrate the extract to obtain ethanol extract, suspend the extract in water, extract with petroleum ether, and concentrate to obtain petroleum ether extract. The ether extract was subjected to silica gel column chromatography, eluted with n-hexane-ethyl acetate gradient, and crystallized in chloroform-methanol solution to obtain β-sitosterol.

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Abstract

The invention discloses the application of a sterol compound and a total sterol extract in preparing antidepressant drugs. The sterol compounds in the present invention mainly include sitosterol, stigmasterol, campesterol, brassicasterol, sterol glycosides, sterol esters and acylated sterol glycosides extracted from plants or traditional Chinese medicines. Animal experiments have shown that the above substances have antidepressant effects on mice.

Description

Technical field: [0001] The invention belongs to the technical field of natural medicinal chemistry. It specifically relates to the application of sterol compounds and total sterol extracts in the preparation of antidepressant drugs. Background technique: [0002] Sterol compounds, especially sterol compounds in plants, mainly include sitosterol, stigmasterol, campesterol, brassicasterol, sterol glycosides, sterol esters and acylated sterol glycosides. Many plants contain sterol compounds, which mainly exist in the form of mixtures in plants. [0003] There are also a lot of reports about the biological activity of sterols. For example, sterol glycosides have complement activation and anti-inflammatory activities; mixtures of sterol glycosides including β-sitosterol glucoside and other β-sitosterol glycosides have immunomodulatory effects; Exzema, psoriasis, asthma and tumors all play a role. Sterols lower cholesterol. However, the effects of sterol components on the ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K31/704A61K36/896A61P25/24
Inventor 崔溶文李光赫杨君马宁
Owner BIOPHARML TECH SHANGHAI
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