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Nanometer silver type external use antibiotic gel for female external use and its preparation method

A nano-silver and gel technology, which is applied in the field of anti-infection, can solve the problems such as the unsatisfactory total effective rate of general treatment, and achieve the effect of remarkable therapeutic effect and high therapeutic efficiency

Inactive Publication Date: 2009-02-04
武汉正午阳光医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there are many treatment products on the market, the total effective rate of general treatment is not ideal

Method used

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  • Nanometer silver type external use antibiotic gel for female external use and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Nano-silver antibacterial gel for external use for women. It is mainly composed of nano-silver, carbomer, triethanolamine, ethylparaben, propylene glycol, ethanol and water to form a gel. The ratio between the raw materials is: nano-silver : Carbomer: Triethanolamine: Ethylparaben: Propylene Glycol: Ethanol: Water = 0.1g: 9g: 10g: 0.9g: 95ml: 190ml: 715ml. Water is deionized water or distilled water (purified water).

[0031] The preparation of above-mentioned nanometer silver women's antibacterial gel for external use, it comprises the steps:

[0032] a. Take 9g of carbomer and add 190ml of 95% ethanol to infiltrate for 24 hours, add 400ml of purified water to soak, make the carbomer fully expand and become a gel matrix, and vacuum defoam after standing;

[0033] b. Add 0.9g of ethylparaben and 95ml of propylene glycol to the gel matrix after vacuum defoaming at a speed of 100-130r / min (clockwise) while stirring to make them evenly mixed, and then at the same speed A...

Embodiment 2

[0037] Nano-silver antibacterial gel for external use, it is mainly composed of nano-silver, carbomer, triethanolamine, ethylparaben, propylene glycol, ethanol and water to form a gel. The ratio between the raw materials is: nano Silver: carbomer: triethanolamine: ethylparaben: propylene glycol: ethanol: water=0.1g: 10g: 11g: 1g: 100ml: 200ml: 700ml. Water is deionized water or distilled water (purified water).

[0038] The preparation of above-mentioned nanometer silver women's antibacterial gel for external use, it comprises the steps:

[0039] a. Take 10g of carbomer and add 200ml of 95% ethanol to infiltrate for 24 hours, add 400ml of purified water to soak, make the carbomer fully expand and become a gel matrix, vacuum degassing after standing; (note: the existing bubbles in the gel);

[0040] b. Add 1g of ethylparaben and 100ml of propylene glycol to the gel matrix after vacuum defoaming at a speed of 100-130r / min (clockwise), and mix them evenly, and then mix them at ...

Embodiment 3

[0051] Nano-silver antibacterial gel for external use for women. It is mainly composed of nano-silver, carbomer, triethanolamine, ethylparaben, propylene glycol, ethanol and water to form a gel. The ratio between the raw materials is: nano-silver : Carbomer: Triethanolamine: Ethylparaben: Propylene Glycol: Ethanol: Water = 0.1g: 11g: 12g: 1.1g: 105ml: 210ml: 685ml.

[0052] Its preparation is basically the same as that of Example 2, except that the proportioning relationship between each raw material is different.

[0053] The nano-silver women's antibacterial gel for external use prepared by above-mentioned embodiment 2 is used for the treatment clinical observation of cervical erosion:

[0054] 1. Objects: A total of 205 cases of cervical erosion in the outpatient clinic, aged 20-45. Pap smears were performed to exclude cancer, and vaginal secretion smears were performed to exclude trichomonas and candida infections.

[0055] 2. Diagnostic criteria:

[0056] According to ...

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Abstract

An exterior-applied antibacterial nano-Ag gel for treating the infection of vagina, cervix uteri and skin of woman is proportionally prepared from Ag nanoparticles, carbomer, triethanolamine, hydroxyphenyl ethylester, propanediol, alcohol and water through mixing.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial external medicine, which is mainly used for anti-infection of women's vaginal mucosa and cervix or human body surface. Background technique [0002] Women's lower reproductive tract infection, mainly cervical erosion, cervicitis, various types of vaginitis (candida vaginitis, bacterial vaginitis, trichomonas vaginitis, senile vaginitis, vaginal mixed infection, etc.) and leucorrhea abnormalities, The incidence rate is higher. Therapeutic drugs include: [0003] Silver has a clear broad-spectrum antimicrobial and wound healing functions. Nano silver is made of simple silver into nanoparticles with a particle size of about 25nm, which is adsorbed on the carrier gel, which can fully contact pathogens and erosive tissue surfaces, and play a role in silver It has the functions of broad-spectrum sterilization, convergence, and promotion of wound healing to treat cervical erosion. [0004] P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K33/38A61K47/34A61P15/02A61P31/04A61K47/32
Inventor 谭波
Owner 武汉正午阳光医药生物科技有限公司