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Use of Tibet picrorhiza rhizome in preparation of medicine for treating atherosclerosis

A technique for atherosclerosis and Tibetan rhizoma rhizoma, which is applied in the application field of Tibetan rhizoma rhizoma in the preparation of atherosclerosis medicine, can solve problems such as application research, and achieve the effects of simple preparation method and convenient source.

Inactive Publication Date: 2009-04-22
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic research reports and patent documents on Huhuanglian in Tibet focus on its hepatoprotective effect and anti-diabetic activity, etc. There is no research on the use of this traditional Chinese medicine in atherosclerosis

Method used

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  • Use of Tibet picrorhiza rhizome in preparation of medicine for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of Tibet Huhuanglian Extract

[0013] The Tibetan Huhuanglian extract of the present invention is prepared by the following method: get the rhizome of Tibetan Huhuanglian (crude drug), air-dried and mechanically pulverize into granular powder (moderate particle size, about 20mm 3 about). Soak 350g of raw material in 2000ml of 50-95% ethanol, purify by percolating overnight, filter under negative pressure, distill at least twice, and finally freeze-dry to make ethanol extract of Coptis chinensis extract, which is sealed and dried for storage. 1g of alcohol extract is equivalent to 3.5g of crude drug. The density of the extract ranges from 1.0005 to 1.0269 g / ml. The organic solvent adopted in the immersion extraction process also can adopt other alcohols, such as methyl alcohol etc. Example 2: Therapeutic Effects of Extract of Huhuanglian from Tibet on Atherosclerosis in New Zealand White Rabbits

Embodiment 2

[0013] The Tibetan Huhuanglian extract of the present invention is prepared by the following method: get the rhizome of Tibetan Huhuanglian (crude drug), air-dried and mechanically pulverize into granular powder (moderate particle size, about 20mm 3 about). Soak 350g of raw material in 2000ml of 50-95% ethanol, purify by percolating overnight, filter under negative pressure, distill at least twice, and finally freeze-dry to make ethanol extract of Coptis chinensis extract, which is sealed and dried for storage. 1g of alcohol extract is equivalent to 3.5g of crude drug. The density of the extract ranges from 1.0005 to 1.0269 g / ml. The organic solvent adopted in the immersion extraction process also can adopt other alcohols, such as methyl alcohol etc. Example 2: Therapeutic Effects of Extract of Huhuanglian from Tibet on Atherosclerosis in New Zealand White Rabbits

[0014] 1.1 In vitro preparation of AGE (advanced glycation end product) and AOPP (advanced protein oxidation ...

Embodiment 3

[0032] Embodiment 3: Oral dosage form prepared with Tibet Huhuanglian

[0033] The Tibetan Huhuanglian described in the present invention can be formulated into oral dosage forms such as tablets, capsules, granules, powders, oral liquids and the like.

[0034] (1) Made into tablets:

[0035] Add the extract of Rhizoma Coptidis Rhizome after alcohol extraction, add appropriate amount of lubricant to make soft material, granulate with 10 mesh sieve, dry, add magnesium stearate to the dry granule, mix well, press tablet machine into tablets, Film-coated, subpackaged to obtain coated tablets.

[0036] (2) Make capsules:

[0037] Spray-dry the extract of Coptis chinensis after alcohol extraction to make powder, pass through a 100-120 mesh sieve, mix evenly with auxiliary materials, pack into capsules, and pack separately to obtain capsules.

[0038] (3) Made into granules:

[0039] Add excipients to the extract of Coptis chinensis after alcohol extraction, granulate, dry, pass ...

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PUM

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Abstract

The invention involves the new uses of Tibet picrorhizae, specifically the application of Tibet picrorhizae in the preparation of drugs for the treatment of atherosclerosis. The alcohol extractive of Tibet picrorhizae rhizome is adopted. The dosage from of the drug is the pharmaceutics permissive peroral dosage form. Tibet picrorhizae has preonunced effect in treating atherosclerosis.

Description

technical field [0001] The invention relates to a new application of Tibetan Huhuanglian, in particular to the application of Tibetan Huhuanglian in the preparation of medicines for treating atherosclerosis. Background technique [0002] In my country, the number of people with atherosclerosis is increasing day by day, and it has become the most common disease. Therefore, strengthening the prevention and treatment of the above diseases is an urgent problem to be solved in my country and even in the world. However, so far, there is still a lack of effective prevention and treatment methods and drugs for the above diseases. [0003] Huhuanglian is a kind of Scrophulariaceae native to India, and its rhizome can be used as medicine. As a traditional Chinese medicinal material, it first appeared in "Tang Materia Medica". It has the functions of clearing away heat and cooling blood, drying dampness and eliminating malnutrition. Before the 1970s, my country's Huhuanglian had alw...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/80A61P9/10A61K125/00
Inventor 侯凡凡刘尚喜梁敏
Owner SOUTHERN MEDICAL UNIVERSITY