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Compound bone peptide medicine composition oral preparation and preparation method therefor

A technology of compound osteopeptide and composition, which is applied in the direction of drug combination, non-active ingredients of polymer compounds, antipyretics, etc.

Inactive Publication Date: 2009-05-13
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on bone peptide products using cyclodextrin inclusion technology has not been reported yet.

Method used

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  • Compound bone peptide medicine composition oral preparation and preparation method therefor
  • Compound bone peptide medicine composition oral preparation and preparation method therefor
  • Compound bone peptide medicine composition oral preparation and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1, oral compound osteopeptide pharmaceutical composition: mix 1100 grams of β-cyclodextrin with 6600 ml of pure water to form a suspension, add 100 grams of paste compound osteopeptide extract under stirring, mix well and then stir After 1 hour, the system was uniformly in the form of a paste, and dried under reduced pressure at 60°C to obtain 1117 g of light yellow solid clathrates.

[0093] The obtained solid clathrate is passed through a 100-mesh sieve for later use, mixed with 100 grams of microcrystalline cellulose, 150 grams of starch, 200 grams of carboxymethyl starch sodium, 20 grams of talcum powder, and 26 grams of stearic acid and then taking 2 / 3 of the medicine Mix excipients and solid clathrates, mix thoroughly, moisten with 70% ethanol to make soft material, pass through 14 mesh sieve to granulate, dry at 50°C, add another 1 / 3 amount of pharmaceutical excipients after sizing, and mix thoroughly Afterwards, the content of the compound bone peptide e...

Embodiment 2

[0094] Example 2: Mix 900 grams of β-cyclodextrin with 2500 milliliters of pure water to form a suspension, add 300 grams of pasty compound bone peptide extract under stirring, mix well and then stir for an hour, the system is evenly paste , and dried under reduced pressure at 60°C to obtain 1136 g of light yellow solid clathrate.

[0095] The obtained solid clathrate is passed through a 100-mesh sieve for later use, mixed with 100 grams of microcrystalline cellulose, 100 grams of starch, 250 grams of carboxymethyl starch sodium, 20 grams of talcum powder, and 26 grams of stearic acid and then taking 2 / 3 of the medicine Mix excipients and solid clathrates, mix thoroughly, moisten with 70% ethanol to make soft material, pass through 14 mesh sieve to granulate, dry at 50°C, add another 1 / 3 amount of pharmaceutical excipients after sizing, and mix thoroughly After the determination of the content, the compound bone peptide inclusion tablet was obtained by tableting.

Embodiment 3

[0096] Example 3: Mix 960 grams of β-cyclodextrin with 2000 milliliters of pure water to form a suspension, add 240 grams of pasty compound bone peptide extract under stirring, mix well and then stir for an hour, the system is evenly paste , and dried under reduced pressure at 60°C to obtain 1126 g of light yellow solid clathrate.

[0097] The obtained solid clathrate is passed through a 100-mesh sieve for later use, mixed with 100 grams of microcrystalline cellulose, 100 grams of starch, 250 grams of carboxymethyl starch sodium, 20 grams of talcum powder, and 26 grams of stearic acid and then taking 2 / 3 of the medicine Mix excipients and solid clathrates, mix thoroughly, moisten with 70% ethanol to make soft material, pass through 14 mesh sieve to granulate, dry at 50°C, add another 1 / 3 amount of pharmaceutical excipients after sizing, and mix thoroughly After the determination of the content, the compound bone peptide inclusion tablet was obtained by tableting.

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Abstract

An orally taken composite osteopeptide medicine is prepared from the composite osteopeptide and cyclodextrin in mass ratio of 1: (4-7) through preparing composite osteopeptide from the limb bone of health pig or fetal calf, and scorpion, mixing cyclodextrin with purified water, adding said composite osteopeptide, stirring and vacuum drying at 45-60 deg.C to obtain included solid.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an oral compound osteopeptide pharmaceutical composition and a preparation method of the pharmaceutical composition. Background technique [0002] Compound bone peptide extract refers to the viscous paste product obtained by extracting 3 parts of healthy pig or fetal bovine limb bone and 1 part of scorpion as raw materials, which is used to prepare compound bone peptide injection Semi-finished product, compound osteopeptide injection is a sterilized aqueous solution made of its extract, containing not less than 15mg of polypeptide substances per 1ml, and not less than 4mg of total nitrogen (National Drug Western Medicine Standard WS1-XG-007-2002 ). Compound osteopeptide is rich in a variety of bone growth factors, the main components: peptides, amino acids, organic calcium, phosphorus, inorganic calcium, inorganic salts, trace elements, etc., each component has a strong mutual coo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K47/40A61K9/14A61P29/00A61P19/02A61P19/10A61K35/32A61K35/36A61K35/646
Inventor 任勇余书勤王晓洁朱冠臣
Owner NANJING NORMAL UNIVERSITY
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