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Preparation of Danshen root microemulsion

A technology of Salvia miltiorrhiza and microemulsion is applied in the field of preparation of salvia miltiorrhiza microemulsion traditional Chinese medicine preparations, which can solve problems such as failure to reflect the overall effect of traditional Chinese medicine salvia miltiorrhiza, achieve multi-target synergy, improve bioavailability, reduce drug dosage and toxic and side effects Effect

Inactive Publication Date: 2009-06-10
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the multi-target action mechanism of traditional Chinese medicine, other active ingredients of Danshen are not encapsulated in tanshinone nanoliposomes and tanshinone microemulsions, failing to reflect the overall effect of traditional Chinese medicine Danshen

Method used

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  • Preparation of Danshen root microemulsion
  • Preparation of Danshen root microemulsion
  • Preparation of Danshen root microemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of Salvia Miltiorrhiza Microemulsion

[0033] Grind high-quality salvia miltiorrhiza into medium-fine powder with a particle size of 20 mesh, place it in a supercritical extraction kettle, and extract it with supercritical CO 2 As an extractant, add 95% ethanol with 30% medicinal material as an entrainer, when the following conditions are met: extraction temperature is 40°C, extraction pressure is 22MPa, analysis I pressure is 11MPa, analysis I temperature is 45°C, analysis II pressure At 7MPa, the circulation extraction is started, and the constant temperature and pressure are maintained. with CO 2 After extracting for 2.0 h at a circulating flow rate of 11 kg / h·kg, the material is discharged from the discharge port to obtain the crude extract of Danshen, which is a dark brown-red suspension liquid. Filter the salvia miltiorrhiza extract through a plug layer filter paper, collect the filter cake A and the filtrate, and further decompress the filtrate to r...

Embodiment 2

[0037] Preparation of Salvia Miltiorrhiza Microemulsion

[0038] Grind high-quality salvia miltiorrhiza into medium-fine powder with a particle size of 20 mesh, place it in a supercritical extraction kettle, and extract it with supercritical CO 2 As an extractant, add 95% ethanol with 40% medicinal material as entrainer, when the following conditions are met: extraction temperature is 50°C, extraction pressure is 28MPa, analysis I pressure is 13MPa, analysis I temperature is 50°C, analysis II pressure At 9MPa, start circular extraction and keep constant temperature and pressure. with CO 2 After extracting for 2.0 h at a circulating flow rate of 11 kg / h·kg, the material is discharged from the discharge port to obtain the crude extract of Danshen, which is a dark brown-red suspension liquid. Filter the salvia miltiorrhiza extract through double-layer filter paper, collect the filter cake A and the filtrate, and further decompress the filtrate to recover ethanol (65 ° C water b...

Embodiment 3

[0042] Preparation of Salvia Miltiorrhiza Microemulsion

[0043] Grind high-quality salvia miltiorrhiza into medium-fine powder with a particle size of 20 mesh, place it in a supercritical extraction kettle, and extract it with supercritical CO 2 As an extractant, add 95% ethanol with 10% medicinal material as an entrainer, when the following conditions are met: extraction temperature is 50°C, extraction pressure is 30MPa, analysis I pressure is 15MPa, analysis I temperature is 40°C, analysis II pressure At 7MPa, the circulation extraction is started, and the constant temperature and pressure are maintained. with CO 2 After extracting for 3.5 hours at a circulating flow rate of 11kg / h·kg, the material is discharged from the discharge port to obtain the crude extract of Danshen, which is a dark brown-red suspension liquid. Filter the salvia miltiorrhiza extract through double-layer filter paper, collect the filter cake A and the filtrate, further reduce the pressure of the fi...

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Abstract

A process for preparing danshin microemulsion includes such steps as extracting the liposoluble active component containing dashinone from red sage root by supercritical fluid, extracting the water-soluble active component from red sage root by ultrasonic technique, dissolving said liposoluble extract in the mixture of emulsifier, co-emulsifier and oil-phase material to obtain organic phase, dissolving said water-soluble extract in water-phase material, dripping it into said organic phase, and filtering by millipore membrane.

Description

technical field [0001] The invention relates to a preparation method of a salvia miltiorrhiza microemulsion traditional Chinese medicine preparation containing fat-soluble and water-soluble components of salvia miltiorrhiza and a drug carrier. Background technique [0002] Blind Danshen powder is the same as Siwu Decoction. Studies have found that Danshen, as a blood-activating and stasis-removing drug, can significantly expand coronary arteries, increase coronary flow, improve microcirculation, protect the heart, inhibit and relieve platelet aggregation, improve the body's ability to withstand hypoxia, anti-inflammatory, anti-lipid Peroxidation and scavenging free radicals, etc., and thus widely used in the clinical treatment of cardiovascular and cerebrovascular diseases. At present, it is generally believed that the effective parts of Danshen that have the activity of promoting blood circulation and removing stasis are mainly water-soluble phenolic acids and fat-soluble ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K9/107A61K9/48A61K47/44A61K47/14A61K47/22A61P9/10A61P39/06A61P7/02A61K125/00
Inventor 张忠义李红磊雷正杰周本杰季爱民
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV