Amide for inhibition of IL-8-induced chemiotaxis of neutrophil leucocytes

A technology of propionamide and arylpropionamide, applied in the direction of amide active ingredients, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as disease progression
CN100513386CInactive Publication Date: 2009-07-15DOMPE FARM SPA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DOMPE FARM SPA
Publication Date
2009-07-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

N-(2-arylpropionyl)-amides represented by the general formula (I) are described. The present invention also describes its preparation method and its pharmaceutical preparation. The amides of the present invention are used to prevent and treat tissue damage caused by the acute recruitment of polymorphonuclear leukocytes (leukocytes PMN) at the site of inflammation. Specifically, the present invention relates to the R enantiomer of N-(2-aryl-propionyl)amide represented by general formula (I) for inhibiting neutrophils induced by interleukin 8 (IL-8). Cell chemotaxis. The compounds of the invention are useful in the treatment of psoriasis, ulcerative cholelithitis, glomerulonephritis, acute respiratory insufficiency, spontaneous fibrosis and rheumatoid arthritis.
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Description

technical field

[0001] The invention relates to N-(2-aryl-propionyl)-amides, processes for their preparation and pharmaceutical preparations for the prevention and treatment of tissue damage caused by the acute recruitment of polymorphonuclear leukocytes (leukocytes PMN) at inflamed sites damage. In particular, the present invention relates to the R enantiomer of N-(2-aryl-propionyl)-amides useful for inhibiting neutrophil chemotaxis induced by interleukin 8 (IL-8). Background technique

[0002] Chemokines constitute a family of low molecular weight cytokines directly involved in inflammatory responses, translocation of immune cells and directed transplantation of cellular components. The technical term "chemokine" is an abbreviation of the words "chemotaxis" and "cytokine", which emphasizes the general biological function of these cellular mediators.

[0003] Chemokines are divided into two subspecies, which are distinguished by the sequence of the amino acids CC and CXC,...

Claims

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