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A surgical suture and new material technology, applied in surgical instruments, medical science, surgery, etc., can solve problems such as backward production technology of catgut, polluting the environment, susceptibility to allergies, and antibody reactions
Inactive Publication Date: 2009-07-22
四川琢新生物材料研究有限公司
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Abstract
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Problems solved by technology
The sheep catgut production process is backward, pollutes the environment, has poor absorbability, and is prone to allergies and antibody reactions
Method used
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Examples
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Effect test
Embodiment 1
[0010] Suture materials, including polytrimethylene carboxylate 15%, intrinsic viscosity 1.2dl / g, molecular weight 300,000, poly-L-lactic acid 75%, intrinsic viscosity 3dl / g, molecular weight 800,000, processed 90cm suture, After disinfection and sterilization, the results of animal experiments show that no matter in vivo or in vitro, the effects of tension strength and nodular firmness are ideal, the tissue reaction is low, and the wound healing is good.
Embodiment 2
[0012] Suture materials, including polytrimethylene carboxylate 20%, intrinsic viscosity 2dl / g, molecular weight 300,000, polyglycolic acid 80%, intrinsic viscosity 8dl / g, molecular weight 2.8 million, processed sutures of 67cm, sterilized , Sterilization treatment, animal test results show that no matter in vivo or in vitro, the effect of tension strength and nodule firmness is ideal, tissue reaction is low, and wound healing is good.
Embodiment 3
[0014] Suture materials, including polyglycolic acid 85%, intrinsic viscosity 5dl / g, molecular weight 1.28 million, poly-L-lactic acid 10%, intrinsic viscosity 4dl / g, molecular weight 1.3 million, poly-L-lysine 5%, molecular weight 30 Wan, the processed 75cm suture has been disinfected and sterilized. The results of animal experiments show that both in vivo and in vitro, the tensile strength and nodular firmness are ideal, the tissue reaction is low, and the wound heals well.
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Abstract
The invention is a new material for surgical suturing, which is a new material processed by copolymerization or blending of biodegradable polylactic acid aliphatic polyester and polyamino acid materials. The selected degradable polymer is completely absorbed by the tissue within 60-180 days. The suture material maintains the highest level of tensile strength and nodular firmness both in vivo and in vitro, and at the same time, it has a stable and predictable absorption rate in conjunction with wound healing. It is simply hydrolyzed in the body and is not affected by enzymes and body fluids. It has good biocompatibility. The tissue response is low, which is very suitable for maintaining the complete anastomosis of sutures for a long time after surgery.
Description
technical field [0001] The invention relates to a new suture material for wound suture or tissue ligation and tissue fixation in surgical operations, in particular a new material processed from biodegradable polylactic acid aliphatic polyester and polyamino acid material copolymerization or blend. Background technique [0002] Medical suture is a special sterile thread for wound suture or tissue ligation and tissue fixation in surgical operations. At present, there are three kinds of medical sutures widely used: silk thread, catgut and aliphatic polyester absorbable suture. The production process of sheep catgut is backward, pollutes the environment, has poor absorbability, and is prone to allergies and antibody reactions. Aliphatic polyester absorbable sutures mainly include polyglycolic acid sutures, polyglycolic acid and polylactic acid copolymer sutures, polydioxanone (PDS) sutures, glycolide and trimethylene carbonate Sutures, etc., have the advantages of: because the...
Claims
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Application Information
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