Biochemical substance sensing method and biosensor optical sensing structue

A sensing method and technology of biochemical substances, applied in the field of biochemical sensors, can solve problems such as difficult conversion to practical instruments and difficult operation of optical waveguide biosensors, and achieve fast multi-channel simultaneous detection and avoid coupling loss effects

Inactive Publication Date: 2009-12-02
李坚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Optical waveguide biosensors are not easy to operate, and a lot of work only stays in the observation of experimental phenomena, and it is not easy to convert them into practical instruments

Method used

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  • Biochemical substance sensing method and biosensor optical sensing structue
  • Biochemical substance sensing method and biosensor optical sensing structue
  • Biochemical substance sensing method and biosensor optical sensing structue

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Example 1, see Figure 1-2 . The thickness of the waveguide 4 in the sensing working area of ​​the present invention is about 30 μm, and the width of the waveguide in the vertical direction is large enough so that each slot can be considered as an anti-resonant planar waveguide. In the middle of the back of the sensor head is a conical microlens light-collecting area, so that the incident light enters the waveguide in the sensing area at an appropriate angle. The third part is an aspheric microlens 1, which is used to collect the fluorescent signal output from the sensing waveguide. Its working principle is as follows: a laser diode is used as a light source, and a self-focusing microlens is used to couple the laser beam into an anti-resonant planar waveguide. The 45° notch is plated with a reflective mirror to form a point light source on the axis of the molded waveguide. This injection of the laser beam at 90° to the axis makes the incident light and the fluorescent ...

Embodiment 2

[0040] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the laser is coupled into the waveguide by a bypass, such as image 3 .

[0041] The substance solution to be tested in the present invention and the high and low optical materials together form the ARROW waveguide, such as Figure 4 .

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Abstract

The biochemical substance sensing method relates to the field of optical technology. In the present invention, a specific antibody labeled with a fluorescent body and a substance to be tested are placed in an anti-resonance planar optical waveguide, irradiated with laser light, and the fluorescent signal is analyzed to determine whether the substance to be tested is Contains antigens that match specific antibodies. The beneficial effects of the invention are as follows: 1) the waveguide light field inside the waveguide is much stronger than the evanescent field outside the waveguide, and thus the fluorescence intensity generated by excitation is also increased by more than ten times. 2) Coupling loss is avoided. 3) The present invention can have more than ten slot waveguide channels to realize fast multi-channel simultaneous detection.

Description

technical field [0001] The invention relates to the field of optical technology, in particular to biochemical sensor technology. Background technique [0002] Since the 1970s, biomedical engineering has developed rapidly, and various biosensors for detecting chemical components in living organisms have emerged continuously. In the mid-1960s, enzyme sensors were first developed by using the catalysis of enzymes and its catalytic specificity, and reached the practical stage; in the 1970s, microbial sensors, immune sensors, etc. were developed; since the 1980s, the concept of biosensors has been obtained. It is recognized that as a branch of sensors, it is independent from chemical sensors and has been developed, which combines bioengineering and semiconductor technology and enters the era of bioelectronic sensors. At present, the combination of bioengineering technology and electronic technology, using the unique functions of organisms to manufacture various sensors similar t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N33/53
Inventor 李坚谢康姜海明谢明杨华军
Owner 李坚
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