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Technique for extracting cynamorlum herba cistanches medicinal materials effective component

An extraction process and technology of Cistanche deserticola, applied in the field of phenylethanol glycosides, efficient extraction of D-mannitol and polysaccharides, can solve problems such as waste of resources and neglect, and achieve the effect of reducing production costs

Inactive Publication Date: 2010-02-17
JIANGSU ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many extraction methods for the biologically functional components of Cistanche deserticola, but most of the extraction methods are limited to the extraction of one biologically functional component, ignoring the extraction of other biologically functional components, resulting in a great waste of resources

Method used

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  • Technique for extracting cynamorlum herba cistanches medicinal materials effective component

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Cistanche powder 1kg, adding 10 times the amount of ethanol with a concentration of 90% (V / V), extracted for 2 hours, then extracted with 8 times the amount of 90% (V / V) ethanol, combined two extracts, concentrated under reduced pressure, Crystallized and dried to obtain 16 g of crystalline material with a D-mannitol content of 50%. The extraction residue was continued to be extracted twice with 80% (V / V) ethanol solution, and the extract was concentrated under reduced pressure and spray-dried to obtain 300 g of Cistanche deserticola alcohol extract, containing 5% of phenylethanol glycosides. Continue to add 10 times the amount of distilled water to the extraction residue, heat and extract twice, add 3 times the volume of 95% ethanol to the supernatant after concentration under reduced pressure for precipitation, let stand at 4°C for 24 hours, collect the precipitate after centrifugation, and dry it. 60g of Cistanche polysaccharide can be obtained with a purity of 75%. ...

Embodiment 2

[0021] Cistanche powder 1kg, add 10 times the amount of 95% (V / V) ethanol, extract for 2 hours, then extract with 8 times the amount of 95% (V / V) ethanol, combine the two extracts, concentrate under reduced pressure, crystallize, and dry 20 g of dried crystals were obtained, and the D-mannitol content was 64%. The extraction residue was continued to be extracted with 10 times the concentration of 80% (V / V) ethanol solution for 2 hours, and then extracted with 70% (V / V) ethanol solution for 2 hours, and the extract was concentrated under reduced pressure, Spray-dry to obtain 350 g of phenylethanol glycosides, and the content of phenylethanol glycosides is 7%. Continue to add 15 times the amount of distilled water to the extraction residue, heat and extract twice, add 3 times the volume of 95% ethanol to the supernatant after concentration under reduced pressure for precipitation, let it stand at 4°C for 24 hours, collect the precipitate after centrifugation, and dry it. 60g of...

Embodiment 3

[0023] Cistanche deserticola powder tkg, add 8 times of amount 90% (V / V) ethanol, extract 2 hours, extract twice, combine two extractions, concentrate under reduced pressure, crystallize, dry to obtain crystalline material 10g, D-mannitol content is 50%. Extract the residue, continue to use 10 times the concentration of 70% (V / V) ethanol solution to carry out reflux extraction twice, the extract is passed through D101 macroporous resin, the eluate is collected, concentrated under reduced pressure, and spray-dried to obtain phenylethanol glycosides 10 g of a purified product with a content of 80%. Continue to add 15 times the amount of distilled water to the extraction residue, decoct and extract twice, add 3 times the volume of 95% ethanol to the supernatant after concentration under reduced pressure for precipitation, let stand at 4°C for 24 hours, collect the precipitate after centrifugation, and dry 70g of Cistanche polysaccharide can be obtained with a purity of 70%.

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Abstract

The invention relates to a technology for extracting active ingredients from Herba Cistanches, and belongs to the technology field of traditional Chinese medicine component extraction. The extractiontechnology comprises the following steps: broomrape is dried and crushed, and is extracted by adopting ethanol ranging from 90 to 95 percent; extracting solution is concentrated, crystallized and dried to obtain broomrape D-mannite; residue is extracted by using ethanol solution the concentration of which ranges from 60 to 80 percent; the extracting solution passes through macroporous resin; eluent is concentrated and dried to obtain broomrape phenethyl alcohol glycosides; the obtained extracting residue is continuously added with distilled water for heat extraction; after being decompressed and concentrated, supernatant fluid is added with the ethanol of 95 percent for deposition, wherein, the volume of the ethanol is three times of the volume of the supernatant fluid; precipitate is dried to obtain broomrape polyoses. Compared with the traditional method, the technology obtains three broomrape biology bioactive components that are broomrape mannite, the broomrape phenethyl alcohol glycosides and the broomrape polyoses at the same time, and the disadvantage that single-component is emphasized excessively in the traditional extracting method is made up. The ethanol which is used can be recovered during the decompressing and concentrating process to achieve the recycling purpose, thereby effectively lowering the production cost.

Description

1. Technical field [0001] The invention relates to a method for extracting and isolating effective components from Chinese medicinal materials, in particular to a method for efficiently extracting D-mannitol, phenylethanol glycosides and polysaccharides from Cistanche medicinal materials, and belongs to the technical field of extracting Chinese medicinal ingredients. 2. Technical background [0002] Cistanche salsa (Cistanche salsa G.Beck), also known as Haloxylon, fine bamboo shoots, goblin, is a precious traditional Chinese medicine in my country, and it is included in the Pharmacopoeia. It mainly grows in desert areas such as western Inner Mongolia, Gansu, and Xinjiang. Cistanche deserticola was first recorded in "Shen Nong's Materia Medica" and listed as top grade. It has the functions of nourishing kidney and strengthening yang, replenishing essence and marrow, nourishing blood and moistening dryness, pleasing color and prolonging life. Cards such as cold pain, blood dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C31/26C07C29/74C07H15/18C08B37/00A61K36/64
Inventor 玄国东刘春泉刘春菊吴海虹
Owner JIANGSU ACAD OF AGRI SCI