The invention discloses a clean and high-conversion-rate preparing method of 2,2,2-trifluroacetophenone. The method includes the following steps of S1, making N,O-dimethylhydroxylamine hydrochloride as the raw material react with organic alkali to obtain free N,O-dimethylhydroxylamine; S2, making trifluoroacetic anhydride react with free N,O-dimethylhydroxylamine to generate N,O-dimethyltrifluoroacetamide; S3, making a Grignard reagent react with N,O-dimethyltrifluoroacetamide to prepare trifluroacetophenone, recovering N,O-dimethylhydroxylamine generated in the step S1, applying N,O-dimethylhydroxylamine to the step S2, and recycling the reaction solvents used in the steps S1, S2 and S3. By means of the preparing method, prepared high-nucleophilicity N,O-dimethyltrifluoroacetamide reactswith the Grignard reagent, 2,2,2-trifluroacetophenone is efficiently prepared, meanwhile produced byproducts can be applied for preparing N,O-dimethyltrifluoroacetamide, and a recycling effect is achieved.