Skeleton slow releasing implant for deworming from dogs and its preparation method

Abstract

The invention discloses a domestic dog insect-repelling frame-typed slow-release plant agent and making method in the drug engineering technical domain, which consists of conventional echinococcosis-proof drug and tissue compatible material with weight rate at 1:0.5-1:30; the tissue compatible material is composed of biological decomposable typed material and non-biological decomposable typed material; the conventional echinococcosis-proof drug is weighed to blend with tissue compatible material according to certain proportion, which is dissolved in the organic solvent under indoor temperature or heating condition; the composition is grinded to add into heat mould, which is squeezed or shaped under indoor temperature after stripping mould.

Description

technical field [0001] The invention relates to a preparation method in the technical field of pharmaceutical engineering, in particular to a domestic dog anthelmintic skeleton-type sustained-release implant and a preparation method thereof. Background technique [0002] Hydatid disease is scientifically known as echinococcosis. It is a parasitic disease that is zoonotic through dogs as an intermediate host. Hydatid disease mainly parasitizes in important organs such as the liver and lungs of humans and livestock, forming worms of different sizes. Cysts compress tissue and affect normal physiological functions. At present, the main means of treating echinococcosis are surgery and drug therapy. Surgical operations, due to the poor identification of the infected part, cannot receive corresponding effects. Even if the operation is successful, the complications after the operation will affect the therapeutic effect of the method. In addition, the operation costs a lot and has c...

AI Technical Summary

Problems solved by technology

Although some areas have received good results in the prevention and treatment of echinococcosis by giving monthly tablets to domestic dogs to deworm, but the above-mentioned agents still have at least the following four shortcomings: ① Commonly used anti-echinococcosis drugs are all fat-soluble drugs, The bioavailability of oral preparations is extremely low, resulting in a huge waste of drugs ② After the anti-hydatid drugs are absorbed through the gastrointestinal tract, most of them are first metabolized by the liver and inactivated. In order to maintain effective blood drug concentrations, the frequency of administration must be increased Or increase the single dose, thereby increasing the cost of echinococcosis prevention and treatment ③The control cycle of canine echinococcosis is long, generally at least 6 months, and the workload of oral tablet therapy is quite large ④Regular administration The method of taking tablets for dogs is difficult to implement in farming and pastoral areas. The specific difficulty is that dogs cannot swallow tablets by themselves. Dogs are highly mobile, and it is dangerous for medical workers to administer medicine to dogs.

"Its shortcomings are as follows: first, the use of inert fillers makes the drug rod too large to be implanted; Leakage of drug and inert filler, so that the sustained release effect cannot be achieved