Method of synthesizing cefixime
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 河源市制药工程技术研究开发中心
- Publication Date
- 2007-08-15
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of cefixime in the chemical pharmaceutical industry, and in particular relates to a synthesis method of cefixime. Background technique
[0002] Cefixime is a third-generation oral cephalosporin antibiotic, which has a broad-spectrum antibacterial effect on Gram-positive and Streptococcus), pneumococcus and Escherichia coli, Moraxella, Neisseria gonorrhoeae, Proteus mirabilis, and Cathaeria in Gram-negative bacteria showed stronger bactericidal effect than other oral cephalosporins. It has the characteristics of broad spectrum, high efficiency, enzyme resistance and low toxicity, and is an anti-infection oral drug widely used in clinical practice.
[0003] The technical status of existing synthetic cefixime is as follows:
[0004] (1) In a reaction tank with a thermometer and a nitrogen device that has replaced air, add MICA (cefixime side chain acid), accelerator DM (dibenzothiazole disulfide), triphenylph...