Method for assaying 3,5-substituted oxazolidones compound content

Abstract

The present invention provides a method for measuring 3, 5-substituted oxazolidone compound content, it is non-water detection method and includes: dissolving the sample by adding acid; adding crystal violet instruction liquid to the dissolved solution; titrating perchloric acid titrating solution to the solution till the solution becomes blue-green; and calculating the content of the sample. The method is convenient in the operation for the content measurement for chemical material medicine and content measurement for comparison sample, has accurate measuring result, and is simple in execution.

Description

technical field

[0001] The invention provides a method for determining the content of 3,5-substituted oxazolidinone compounds, which is a non-aqueous titration method. The method is easy to operate in the content determination of chemical raw materials and reference substances. The result is accurate and easy to operate. Background technique

[0002] Antimicrobial resistance is a major problem facing the world today. Since the 1980s, multidrug-resistant gram-positive bacteria have become the main pathogens of hospital-acquired pneumonia. At present, the treatment of Gram-positive bacterial infections is mostly caused by drug-resistant bacteria, so that there are very few therapeutic drugs available for clinical use, which has become a major clinical challenge. Staphylococci can acquire multidrug resistance, especially in nosocomial infections, but also in community-acquired infections. The drug resistance mechanism of pathogenic bacteria is also constantly evolving. Repor...

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